Preparation and Antioxidant Activity of Chitosan Dimers with Different Sequences

Hao, Wentong; Li, Kecheng; Ma, Yuzhen; Li, Rongfeng; Xing, Ronge; Yu, Huahua; Li, Pengcheng

doi:10.3390/md19070366

Cited by 28 publications

(14 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The COSs were analyzed by hydrophilic interaction liquid chromatography using an LC-2030C 3D Plus HPLC system (SHIMADZU, Kyoto, Japan) with an evaporative light scattering detector (Essentia ELSD-16) through the techniques available in our laboratory. The MS detection refers to the method we have published before [ 43 ].…”

Section: Methodsmentioning

confidence: 99%

The Effect of N-Acetylation on the Anti-Inflammatory Activity of Chitooligosaccharides and Its Potential for Relieving Endotoxemia

Hao

et al. 2022

IJMS

Self Cite

View full text Add to dashboard Cite

Endotoxemia is mainly caused by a massive burst of inflammatory cytokines as a result of lipopolysaccharide (LPS) invasion. Chitooligosaccharides (COS) is expected to be a potential drug for relieving endotoxemia due to its anti-inflammatory properties. However, the structural parameters of COS are often ambiguous, and the effect of degree of acetylation (DA) of COS on its anti-inflammatory remains unknown. In this study, four COSs with different DAs (0%, 12%, 50% and 85%) and the same oligomers distribution were successfully obtained. Their structures were confirmed by 1H NMR and MS analysis. Then, the effect of DA on the anti-inflammatory activity and relieving endotoxemia potential of COS was researched. The results revealed that COS with a DA of 12% had better anti-inflammatory activity than COSs with other DAs, mainly in inhibiting LPS-induced inflammatory cytokines burst, down-regulating its mRNA expression and reducing phosphorylation of IκBα. Furthermore, this COS showed an obviously protective effect on endotoxemia mice, such as inhibiting the increase in inflammatory cytokines and transaminases, alleviating the injury of liver and intestinal tissue. This study explored the effect of DA on the anti-inflammatory activity of COS for the first time and lays the foundation for the development of COS as an anti-inflammatory drug against endotoxemia.

show abstract

Section: Methodsmentioning

confidence: 99%

The Effect of N-Acetylation on the Anti-Inflammatory Activity of Chitooligosaccharides and Its Potential for Relieving Endotoxemia

Hao

et al. 2022

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Chitosan shows a greater ability in scavenging free radicals having relatively low molecular weights and higher levels of acetylation ( Negm et al, 2020 ). Chitosan derivatives obtained by chemical modification can improve the antioxidant capacity of polymers and increase their application over a range of fields ( Hao et al, 2021 ). Chitosan composite films prepared with ascorbate have stronger DPPH radical–scavenging ability and improved ability in resisting ultraviolet-visible light and visible light ( Tan et al, 2020 ).…”

Section: Biological Characteristics Of Chitosan and Its Derivativesmentioning

confidence: 99%

Applications of Chitosan and its Derivatives in Skin and Soft Tissue Diseases

Xia

Wang

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Chitosan and its derivatives are bioactive molecules that have recently been used in various fields, especially in the medical field. The antibacterial, antitumor, and immunomodulatory properties of chitosan have been extensively studied. Chitosan can be used as a drug-delivery carrier in the form of hydrogels, sponges, microspheres, nanoparticles, and thin films to treat diseases, especially those of the skin and soft tissue such as injuries and lesions of the skin, muscles, blood vessels, and nerves. Chitosan can prevent and also treat soft tissue diseases by exerting diverse biological effects such as antibacterial, antitumor, antioxidant, and tissue regeneration effects. Owing to its antitumor properties, chitosan can be used as a targeted therapy to treat soft tissue tumors. Moreover, owing to its antibacterial and antioxidant properties, chitosan can be used in the prevention and treatment of soft tissue infections. Chitosan can stop the bleeding of open wounds by promoting platelet agglutination. It can also promote the regeneration of soft tissues such as the skin, muscles, and nerves. Drug-delivery carriers containing chitosan can be used as wound dressings to promote wound healing. This review summarizes the structure and biological characteristics of chitosan and its derivatives. The recent breakthroughs and future trends of chitosan and its derivatives in therapeutic effects and drug delivery functions including anti-infection, promotion of wound healing, tissue regeneration and anticancer on soft tissue diseases are elaborated.

show abstract

“…Interaction of free radicals with primary amino groups in the chitosan plays a focal role in exhibiting their antioxidant activity. [ 73 ] Deacetylated chitosan with low molecular weight is proved as a natural antioxidant. Chitosan films incorporated with thyme oil are found have good antioxidant and antibacterial properties and these films are frequently used in wound dressing applications.…”

Section: Properties Of Chitosan Assisting Drug Deliverymentioning

confidence: 99%

Chitosan‐Based Films in Drug Delivery Applications

2022

View full text Add to dashboard Cite

The idea of controlled release of the pharmaceutical active ingredients in the human body has become a major thrust for designing sophisticated drug delivery systems. The mandatory requirement for developing these delivery vehicles is to support the delivery of pharmaceutical drugs in a pharmokinetically controlled manner. Though a variety of synthetic polymers address the above mentioned conditions, their toxicity and high cost have ultimately hampered their role. Consequently, natural polymers owing to their biocompatibility, biodegradability, and nontoxicity can be used for the successful designing of drug delivery supports. One such natural polymer extracted from crustaceans, is chitosan. Chitosan can be used in drug delivery in various forms like hydrogels, nanoparticles, nanofibers, films, etc. This review presents the properties of chitosan films and their pivotal role in various drug delivery approaches.

show abstract

Preparation and Antioxidant Activity of Chitosan Dimers with Different Sequences

Cited by 28 publications

References 41 publications

The Effect of N-Acetylation on the Anti-Inflammatory Activity of Chitooligosaccharides and Its Potential for Relieving Endotoxemia

The Effect of N-Acetylation on the Anti-Inflammatory Activity of Chitooligosaccharides and Its Potential for Relieving Endotoxemia

Applications of Chitosan and its Derivatives in Skin and Soft Tissue Diseases

Chitosan‐Based Films in Drug Delivery Applications

Contact Info

Product

Resources

About