Chitosan‐Based Films in Drug Delivery Applications

Radha, Divya; Lal, Jisha S; Devaky, K. S.

doi:10.1002/star.202100237

Cited by 10 publications

(3 citation statements)

References 121 publications

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“…This is especially useful in applications like wound dressings where infection prevention is crucial [ 163 ]. Moreover, the films can be used as drug delivery systems, with the drug incorporated within the film and released over time [ 164 ]. Similar properties are exhibited by chitosan–poly(vinyl alcohol) [ 165 ], chitosan–poly(acrylic acid) [ 166 ], chitosan–polyethylene glycol [ 167 ], and chitosan–alginate systems [ 103 ].…”

Section: The Most Important Chitosan-based Antibacterial Materialsmentioning

confidence: 99%

Chitosan and Its Derivatives: Preparation and Antibacterial Properties

Egorov,

Kirichuk,

Rubanik

et al. 2023

Materials

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This comprehensive review illuminates the various methods of chitosan extraction, its antibacterial properties, and its multifarious applications in diverse sectors. We delve into chemical, physical, biological, hybrid, and green extraction techniques, each of which presents unique advantages and disadvantages. The choice of method is dictated by multiple variables, including the desired properties of chitosan, resource availability, cost, and environmental footprint. We explore the intricate relationship between chitosan’s antibacterial activity and its properties, such as cationic density, molecular weight, water solubility, and pH. Furthermore, we spotlight the burgeoning applications of chitosan-based materials like films, nanoparticles, nonwoven materials, and hydrogels across the food, biomedical, and agricultural sectors. The review concludes by highlighting the promising future of chitosan, underpinned by technological advancements and growing sustainability consciousness. However, the critical challenges of optimizing chitosan’s production for sustainability and efficiency remain to be tackled.

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Section: The Most Important Chitosan-based Antibacterial Materialsmentioning

confidence: 99%

Chitosan and Its Derivatives: Preparation and Antibacterial Properties

Egorov,

Kirichuk,

Rubanik

et al. 2023

Materials

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“…This polymer exhibits minimal foreign body reaction, controllable mechanical/biodegradation properties, biocompatibility, hydrophilicity, non-toxicity, non-antigenicity, and antimicrobial activity, as well as bioadherence and cell affinity. Due to its interesting properties, CS is extensively used in biomedical applications as a matrix for drug encapsulation and controlled release [ 7 , 8 ], but also as an antimicrobial agent, alone or with other natural and synthetic polymers [ 9 , 10 , 11 , 12 ]. CS is also known to have antimicrobial activity against periodontal pathogens ( Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans ) [ 13 , 14 ] and was used with good results for periodontal treatment in clinical trials [ 15 , 16 ], as well as a film matrix for the periodontal delivery of different drugs, such as tetracycline [ 17 ], ciprofloxacin and diclofenac [ 18 ], lincomycin [ 19 ], metronidazole [ 20 ], risedronate [ 21 ], metformin [ 22 ] or sparfloxacin [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

PVA/Chitosan Thin Films Containing Silver Nanoparticles and Ibuprofen for the Treatment of Periodontal Disease

Constantin¹,

Lupei²,

Bucatariu³

et al. 2022

Polymers

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Local delivery of drugs or antimicrobial agents is a suitable approach in the management of periodontitis when the infection is localized deep in the pockets and does not adequately respond to mechanical debridement and/or systemic antibiotic treatment. In this context, the objective of this study was to prepare new biocomposite films with antimicrobial, anti-inflammatory, and good mechanical properties to be applied in periodontal pockets. The composite film is eco-friendly synthesized from poly(vinyl alcohol) (PVA) cross-linked with oxidized chitosan (OxCS). Silver nanoparticles (AgNps) were inserted during film synthesis by adding freshly chitosan-capped AgNps colloidal solution to the polymer mixture; the addition of AgNps up to 1.44 wt.% improves the physico-chemical properties of the film. The characterization of the films was performed by FT-IR, atomic mass spectrometry, X-ray spectroscopy, and SEM. The films displayed a high swelling ratio (162%), suitable strength (1.46 MPa), and excellent mucoadhesive properties (0.6 N). Then, ibuprofen (IBF) was incorporated within the best film formulation, and the IBF-loaded PVA/OxCS-Ag films could deliver the drug in a sustained manner up to 72 h. The biocomposite films have good antimicrobial properties against representative pathogens for oral cavities. Moreover, the films are biocompatible, as demonstrated by in vitro tests on HDFa cell lines.

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“…Among the mucoadhesive film-forming polymers, chitosan is a good candidate with several advantages. Chitosan is a safe, biocompatible, and biodegradable polymer with adequate mucoadhesive properties, in addition to permeation enhancer properties, which could be improved by polymer salification with ascorbic acid [2,3]. The main aim of our research is to investigate the permeation of different active pharmaceutical ingredients with different log P through the buccal mucosa using chitosan ascorbate-based mucoadhesive films.…”

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confidence: 99%