Preparation and antibacterial activity of a water-soluble chitosan derivative

Xie, Wenming; Xu, Pengcheng; Wang, Wei; Liu, Qing

doi:10.1016/s0144-8617(01)00370-8

Cited by 274 publications

(89 citation statements)

References 13 publications

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“…Saec and P. zingiber was presented by Zhong et al [87]. The antibacterial activities of hydroxypropyl chitosan at different concentrations against Staphylococcus aureus and Escherichia coli have been explored by Xia et al [88].…”

Section: Influence Of Concentrationmentioning

confidence: 99%

Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation

et al. 2011

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Abstract:The physicochemical nature of chitin and chitosan, which influences the biomedical activity of these compounds, is strongly related to the source of chitin and the conditions of the chitin/chitosan production process. Apart from widely described key factors such as weight-averaged molecular weight (M W ) and degree of N-acetylation (DA), other physicochemical parameters like polydispersity (M W /M N ), crystallinity or the pattern of acetylation (P A ) have to be taken into consideration. From the biological point of view, these parameters affect a very important factor-the solubility of chitin and chitosan in water and organic solvents. The physicochemical properties of chitosan solutions can be controlled by manipulating solution conditions (temperature, pH, ionic strength, concentration, solvent). The degree of substitution of the hydroxyl and the amino groups or the degree of quaternization of the amino groups also influence the mechanical and biological properties of chitosan samples. Finally, a considerable research effort has been directed towards developing safe and efficient chitin/chitosan-based products because many factors, like the size of nanoparticles, can determine the biomedical characteristics of medicinal products. The influence of these factors on the biomedical activity of chitin/chitosan-based products is presented in this report in more detail. OPEN ACCESSPolymers 2011, 3 1876

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Section: Influence Of Concentrationmentioning

confidence: 99%

Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation

et al. 2011

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“…Every chitosan derivative has to be measured by FT-IR, 1 H NMR, 13 C NMR, and elemental analysis. The FT-IR, 1 H NMR, and 13 C NMR spectra of chitosan, 6-oxychitosan, 1, 2, and 3 are exhibited in Figure 1, and their elemental analysis, yield, and DS are shown in Table 1.…”

Section: Chemical Synthesis and Characterizationmentioning

confidence: 99%

“…For derivative 1, the signal strength of the peak at 1645 cm −1 became stronger and the new peak at 1464 cm −1 in FT-IR could prove the existence of a quaternary ammonium salt. The peak at 7.43 ppm in 1 H NMR and the several peaks at 125 ppm-135 ppm in 13 C NMR could testify to the existence of the monosubstituted benzene ring. For derivative 2, it also applicable to the same analysis method.…”

Section: Chemical Synthesis and Characterizationmentioning

confidence: 99%

“…After modification, the restriction of water solubility which is its weakness will be overcome and it will obviously improve their biological activities [11]. According to previous studies, chitosan derivatives such as hydroxypropyl chitosan, O-hydroxyethyl chitosan, carboxymethyl chitosan, and quaternized chitosan, among others, also show more significant antimicrobial activity [12][13][14]. Quaternary ammonium salt derivatives of chitosan are very vital chitosan derivatives, because they have good solubility in an aqueous solution at neutral pH and shows excellent antimicrobial activity at this condition [15].…”

Section: Introductionmentioning

confidence: 99%

“…By this way, we obtained the target chitosan derivatives which were supposed to have ideal water solubility and antimicrobial activity. What's more, the structure and physicochemical characteristics of new chitosan derivatives were characterized using FT-IR, 1 H NMR, 13 C NMR, and elemental analysis. The two common plant-threatening fungi, Verticillium albo-atrum (CGMCC 3.2869) and Phytophthora hibernalis (CGMCC 3.986), and three universal plant disease bacteria, Xanthomonas oryzae (CGMCC 1.0843), Pseudomonas syringae (CGMCC 1.1844), and Erwinia rhapontici (CGMCC 1.6978) were chosen to test the antimicrobial activity of the target chitosan derivatives.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization, and Anti-Phytopathogen Evaluation of 6-Oxychitosan Derivatives Containing N-Quaternized Moieties in Its Backbone

Gao

Qin

Liu

et al. 2018

International Journal of Polymer Science

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The structure modification of chitosan has great application potential. 6-Oxychitosan was prepared by specially oxidizing the C6-OH of chitosan, then 6-oxychitosan was reacted with three kinds of aldehydes to prepare N-quaternized 6-oxychitosan derivatives in this paper. The derivatives were characterized by FT-IR, NMR, and elemental analysis. The antimicrobial activity of these derivatives was tested against two common plant-threatening fungi and three plant disease bacteria. The results showed that N-quaternized 6-oxychitosan derivatives had good water-solubility and excellent antimicrobial activity. Moreover, derivative 3 which connected 8-hydroxyquinolines had the highest antimicrobial activity than the other derivatives. The inhibitory indices of derivative 3 against V. albo-atrum and P. hibernalis are 89.1% and 72.8% at 0.4 mg/ml. The MICs of 3 against X. oryzae, P. syringae, and E. rhapontici were 625, 625, and 156 mg/l, respectively. All the results indicate that derivative 3 has the potential of becoming an alternative to harmful agricultural chemicals.

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Flocculation Performances of Polymers and Nanomaterials for the Treatment of Industrial Wastewaters

Fosso‐Kankeu

Waanders

Mulaba‐Bafubiandi

et al. 2016

Smart Materials for Waste Water Applications

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Preparation and antibacterial activity of a water-soluble chitosan derivative

Cited by 274 publications

References 13 publications

Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation

Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation

Synthesis, Characterization, and Anti-Phytopathogen Evaluation of 6-Oxychitosan Derivatives Containing N-Quaternized Moieties in Its Backbone

Flocculation Performances of Polymers and Nanomaterials for the Treatment of Industrial Wastewaters

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