Preparation and adsorption characteristic of polymeric microsphere with strong adsorbability for creatinine

Abstract

Cross-linking terpolymer microspheres (HEMA/NVP/MBA; it can also be designated as HEMA/NVP because HEMA and NVP are main components) with an average diameter of 180 microm, were prepared via inverse suspension copolymerization by using 2-hydroxyethyl methacrylate (HEMA) and N-vinylpyrrolidone (NVP) as monomers and N,N'-methylene bisacrylamide (MBA) as cross-linked agent. The microsphere HEMA/NVP was chemically modified with 3,5-dinitrobenzoyl chloride (DNBC), and the functional microsphere DNBZ-HEMA/NVP, on which a great number of 3,5-dinitrobenzoate group (DNBZ) were bound, was obtained. The functional microsphere DNBZ-HEMA/NVP were characterized with FTIR and the chemical analysis method. The adsorption characteristics and mechanism of the absorption of DNBZ-HEMA/NVP for creatine was mainly studied. The results of static adsorption experiments show that the functional microsphere DNBZ-HEMA/NVP has very strong adsorption ability for creatinine, and the saturated adsorption amount is 25 mg/g. The adsorption capacity of the functional microsphere DNBZ-HEMA/NVP for creatinine is enhanced 20 times as against unmodified microsphere HEMA/NVP. The adsorption capacity is smaller, at lower and higher pH, and has a maximum as pH 8.5. The higher the salinity of the medium, the smaller the adsorption capacity. The adsorption capacity decreases with increasing temperature. The study results show that the adsorption of the microsphere DNBZ-HEMA/NVP for creatinine is ascribed to a chemical adsorption by driving of electrostatic interaction.

Preparation of surface molecularly imprinted polymeric microspheres and their recognition property for basic protein lysozyme

“…[26], inverse suspension polymerization method was used for the preparation of crosslinked microspheres HEMA/NVP, and the typical process was as follows. The continuous phase (oil phase) was consisted of 60 mL of liquid paraffin containing 1.30 g of oil-soluble surfactant Span-60 that was used as suspension stabilizer.…”

Synthesis, in vitro macrophage response and detoxification of bamboo charcoal beads for purifying blood

“…Additionally, the fine particles that are released from the adsorbents may embolize the vessels or the circulation of orifices in the body 7. Composite adsorbents14 and millimeter‐sized beads are often adopted 15. The former are biocompatible polymers that bind the charcoal and eliminate the risk of embolization.…”

“…Because the current clinical practice of blood purification avoids direct contact of the blood of a patient during hemoperfusion, the hemolysis level of the bamboo charcoal beads developed in this study was not strictly constrained. However, some novel applications of polymer‐coated activated charcoal use direct hemoperfusion with hemodialysis, as in creatinine adsorption 14–15, 18. In such cases, a low hemolysis level of blood adsorbent is strongly preferred.…”

Comparative Study on the Adsorption Capacities of the Three Black Phosphorus-Based Materials for Methylene Blue in Water

“…pH played an important role during the adsorption process [69]. The changes of pH would cause changes in the chemical form of ionic organic compounds (IOCs), which could change their adsorption characteristics in turn [70]. Due to the two pKa values of MB at 4.52 and 5.85, it could be a cationic (with a positive charge, MB + ), anionic (with a negative charge, MB − ), and amphiphilic molecule (MB 0 ) [71].…”