Preoperative use of sotalol versus atenolol for atrial fibrillation after cardiac surgery

Efeito da denervação cardíaca ventral na incidência de fibrilação atrial após revascularização cirúrgica do miocárdio

“…A randomized study of 253 patients showed a reduction in the incidence of AF with both drugs (sotalol being more effective) however the pro-arrhythmogenic effect of these drugs remains uncertain [13]. In another study, Wanderley et al [14], comparing the use of low-dose propranolol and sotalol in the postoperative period of CABG and obtained an overall incidence of AF of 7.1% which was lower in the group taking sotalol but without significant statistical difference.…”

Atrial fibrillation after cardiac surgery: Risk factors and their temporal relationship in prophylactic drug strategy decision

“…Prophylactic strategies directed toward reduction of postoperative AF have mainly focused on antiarrhythmic drugs. Amiodarone and β-blockers have been found to reduce but not abolish this postoperative arrhythmia [6,14,15]. Several patients still experience AF despite prophylactic therapy, and a large number of the remaining patients are unnecessarily exposed to such drugs with potential adverse events.…”

Atrial fibrillation post-cardiac surgery: changing perspectives

“…Some studies specifically addressed this question. In comparative studies, the prophylactic use of sotalol was associated with a lower frequency of postoperative AF (Table 1) as well as less postoperative supraventricular tachycardia (SVT) [18][19][20][21] . In one study, sotalol appeared to be more effective than propranolol in preventing SVT, but the difference did not reach statistical significance 22 .…”