Preoperative thrombocytopenia and outcomes of hepatectomy for hepatocellular carcinoma

Venkat, Raghunandan; Hannallah, Jack; Krouse, Robert S.; Maegawa, Felipe B.

doi:10.1016/j.jss.2015.08.038

Cited by 24 publications

(24 citation statements)

References 43 publications

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“…These findings suggest that platelet count may be superior to ICG R15 level in predicting PHLF development in HCC patients. This suggestion is compatible with some previous reports .…”

Section: Discussionsupporting

confidence: 94%

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Platelet count is more useful for predicting posthepatectomy liver failure at surgery for hepatocellular carcinoma than indocyanine green clearance test

Tomimaru

Eguchi

Gotoh

et al. 2016

Journal of Surgical Oncology

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“…These findings suggest that platelet count may be superior to ICG R15 level in predicting PHLF development in HCC patients. This suggestion is compatible with some previous reports .…”

Section: Discussionsupporting

confidence: 94%

“…These findings suggest that platelet count may be superior to ICG R15 level in predicting PHLF development in HCC patients. This suggestion is compatible with some previous reports [14,15]. ICG R15 has long been considered one of most reliable methods for assessing reserved liver function in surgical patients [9][10][11][12][13].…”

Section: Discussionsupporting

confidence: 92%

Platelet count is more useful for predicting posthepatectomy liver failure at surgery for hepatocellular carcinoma than indocyanine green clearance test

Tomimaru

Eguchi

Gotoh

et al. 2016

Journal of Surgical Oncology

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“…Tomimaru and colleagues did not report the timing of platelet measurement. Eight studies included only patients who underwent hepatectomy for primary liver malignancy. Alkozai and colleagues, Reidiger et al .…”

Section: Resultsmentioning

confidence: 99%

“…. A total of 3487 patients from seven studies were included in the meta‐analysis of the 100/nl PLT cut‐off. Deaths in the two groups were not reported separately by Alkozai and colleagues, so deaths were calculated in each group based on the number of patients and the OR.…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of the prognostic role of perioperative platelet count in posthepatectomy liver failure and mortality

Mehrabi

Golriz

Khajeh

et al. 2018

British Journal of Surgery

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“…[19] Similarly, PLT cut-off values of 80 and 100 ×10 9 /L were used. [27,28] Two-tailed P < 0.05 values were considered statistically significant.…”

Section: Methodsmentioning

confidence: 99%

Liver transplantation versus surgical resection for HCC meeting the Milan criteria

Shen

Wen

et al. 2016

Medicine

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The optimal treatment (liver transplantation [LT] vs surgical resection [SR]) for early-stage hepatocellular carcinoma (HCC) remains controversial.A total of 209 SR patients and 129 LT patients were identified at our institution. After eliminating 27 patients with Child–Pugh C, the data from 209 SR patients and 102 LT patients were analyzed using a propensity score matching (PSM) model. Forty-six pairs were generated. A subgroup analysis was conducted based on the alpha-fetoprotein (AFP) level or platelet count (PLT). A survival analysis was performed using the Kaplan–Meier method.Gender, satellite lesions, and the treatment method were predictors of HCC recurrence. The Ishak score and treatment methods were associated with long-term survival after surgery. Before PSM, LT patients had a better prognosis than those treated by SR. Among HCC patients with childhood A/B cirrhosis, after PSM, SR achieved similar overall survival outcomes compared with LT. LT and SR resulted in comparable long-term survival for patients with or without thrombocytopenia. Patients with an AFP ≥ 400 ng/mL might achieve more survival benefits from LT.Our propensity score model provided evidence that, compared with transplantation, surgical resection could result in comparable long-term survival for resectable early-stage HCC patients, except for the AFP ≥ 400 ng/mL HCC subgroup. Surgical resection might not be a contraindication for early-stage HCC patients with thrombocytopenia due to their similar prognosis after transplantation.

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Preoperative thrombocytopenia and outcomes of hepatectomy for hepatocellular carcinoma

Cited by 24 publications

References 43 publications

Platelet count is more useful for predicting posthepatectomy liver failure at surgery for hepatocellular carcinoma than indocyanine green clearance test

Platelet count is more useful for predicting posthepatectomy liver failure at surgery for hepatocellular carcinoma than indocyanine green clearance test

Meta-analysis of the prognostic role of perioperative platelet count in posthepatectomy liver failure and mortality

Liver transplantation versus surgical resection for HCC meeting the Milan criteria

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