Platelet count is more useful for predicting posthepatectomy liver failure at surgery for hepatocellular carcinoma than indocyanine green clearance test

Tomimaru, Yoshito; Eguchi, Hidetoshi; Gotoh, Kunihito; Kikuchi, Kôichi; Wada, Hiroshi; Asaoka, Tadafumi; Noda, Takehiro; Yamada, Daisaku; Ogawa, Hisataka; Umeshita, Koji; Nagano, Hiroaki; Doki, Yuichiro; Mori, Masaki

doi:10.1002/jso.24166

Cited by 58 publications

(51 citation statements)

References 20 publications

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“…PLT was measured before surgery in nine studies, and immediately after or 1 day after surgery in six. Tomimaru and colleagues did not report the timing of platelet measurement. Eight studies included only patients who underwent hepatectomy for primary liver malignancy.…”

Section: Resultsmentioning

confidence: 99%

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Meta-analysis of the prognostic role of perioperative platelet count in posthepatectomy liver failure and mortality

Mehrabi

Golriz

Khajeh

et al. 2018

British Journal of Surgery

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Section: Resultsmentioning

confidence: 99%

“…Tomimaru and colleagues did not report the timing of platelet measurement. Eight studies included only patients who underwent hepatectomy for primary liver malignancy. Alkozai and colleagues, Reidiger et al .…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of the prognostic role of perioperative platelet count in posthepatectomy liver failure and mortality

Mehrabi

Golriz

Khajeh

et al. 2018

British Journal of Surgery

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“…Bennett and Blumgart31 also reported the need for extra perioperative care with hepatic resections in patients with a platelet count of <100×10 3 /µL. More recently, Tomimaru et al32 reported a significant correlation between preoperative platelet count and PHLF in both minor and major hepatectomies at a cutoff of <150×10 3 /µL. Thrombocytopenia at the above-mentioned cutoff was a better predictor for PHLF than other parameters such as intraoperative blood loss and ICG R15 .…”

Section: Discussionmentioning

confidence: 97%

Predictors of post-hepatectomy liver failure in patients undergoing extensive liver resections for hepatocellular carcinoma

Chin

Allen

Teo

et al. 2018

Ann Hepatobiliary Pancreat Surg

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Backgrounds/AimsTo determine the prevalence of post-hepatectomy liver failure/insufficiency (PHLF/I) in patients undergoing extensive hepatic resections for hepatocellular carcinoma (HCC) and to assess the predictive value of preoperative factors for post-hepatectomy liver failure or insufficiency (PHLF/I).MethodsA retrospective review of patients who underwent liver resections for HCC between 2001 and 2013 was conducted. Preoperative parameters were assessed and analyzed for their predictive value of PHLF/I. Definitions used included the 50–50, International Study Group of Liver Surgery (ISGLS) and Memorial Sloan Kettering Cancer Centre (MSKCC) criteria.ResultsAmong the 848 patients who underwent liver resections for HCC between 2001 and 2013, 157 underwent right hepatectomy (RH) and extended right hepatectomy (ERH). The prevalence of PHLF/I was 7%, 41% and 28% based on the 50–50, ISGLS and MSKCC criteria, respectively. There were no significant differences in PHLF/I between RH and ERH. Model for End-Stage Liver Disease (MELD) score and bilirubin were the strongest independent predictors of PHLF/I based on the 50–50 and ISGLS/MSKCC criteria, respectively. Predictive models were developed for each of the criteria with multiple logistic regression.ConclusionsMELD score, bilirubin, alpha-fetoprotein and platelet count showed significant predictive value for PHLF/I (all p<0.05). A composite score based on these factors serves as guideline for physicians to better select patients undergoing extensive resections to minimize PHLF.

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“…In contrast, many patients with HCC and elevated APRI often have a low PLT level. Progressive destruction of an enlarged spleen and progressive liver fibrosis can often lead to low preoperative PLT,35–37 and there were also close relationships between low preoperative PLT and great risk of major liver-related complications 37,38. All of these factors and events are closely linked to poor clinical outcomes in HCC patients.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of aspartate aminotransferase to platelet ratio index as a noninvasive biomarker in patients with hepatocellular carcinoma: a meta-analysis

Zeng¹,

Zhang²

2018

CMAR

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BackgroundThe aspartate aminotransferase-to-platelet ratio index (APRI) has been correlated with clinical outcome in patients with hepatocellular carcinoma (HCC), but controversial results were obtained with previous studies. This study was aimed to evaluate the prognostic value of the APRI in patients with HCC.Materials and methodsA literature survey was conducted by searching PubMed, Web of Science, Cochrane library, Embase, Wanfang, and National Knowledge Infrastructure for publications released prior to March 1, 2018. Pooled hazard ratios (HRs) with 95% CIs were calculated to assess the association between the APRI and HCC prognosis using Stata SE 12.0 software.ResultsAnalysis was performed on a total of 15 articles that included 5,051 patients. The pooled results showed that APRI was significantly associated with overall survival for patients with HCC (HR =1.62, 95% CI: 1.23–2.01). Furthermore, HCC patients with higher APRI were at significantly greater risk of short recurrence-free survival (HR =1.83, 95% CI: 1.48–2.18) and poor disease-free survival (HR =1.46, 95% CI: 1.26–1.66).ConclusionsAPRI could serve as a promising and noninvasive marker for predicting HCC prognosis.

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Platelet count is more useful for predicting posthepatectomy liver failure at surgery for hepatocellular carcinoma than indocyanine green clearance test

Abstract: Platelet count is superior to ICG R15 level in predicting PHLF development in HCC patients. J. Surg. Oncol. 2016;113:565-569. © 2016 Wiley Periodicals, Inc.

Cited by 58 publications

References 20 publications

Meta-analysis of the prognostic role of perioperative platelet count in posthepatectomy liver failure and mortality

Meta-analysis of the prognostic role of perioperative platelet count in posthepatectomy liver failure and mortality

Predictors of post-hepatectomy liver failure in patients undergoing extensive liver resections for hepatocellular carcinoma

Prognostic value of aspartate aminotransferase to platelet ratio index as a noninvasive biomarker in patients with hepatocellular carcinoma: a meta-analysis

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