Preoperative <sup>11</sup>C‐Methionine PET/CT Enables Focussed Parathyroidectomy in MIBI‐SPECT Negative Parathyroid Adenoma

Lenschow, Christina; Gaßmann, Peter; Wenning, Christian; Senninger, N.; Colombo-Benkmann, Mario

doi:10.1007/s00268-015-2992-x

Cited by 20 publications

(38 citation statements)

References 39 publications

(61 reference statements)

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“…[ 11 ] There have been a few reports for the use of 11 C-methionine PET as a promising imaging modality for localizing parathyroid adenomas. [ 12 ]…”

Section: Discussionmentioning

confidence: 99%

A rare case of giant parathyroid adenoma presenting with recurrent episodes of pancreatitis

Raghunandan

Ramshankar

2016

Indian J Nucl Med

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Parathyroid adenomas are usually small in size; (weighing 70 mg–1 g) those weighing more than 2–3 g are classified as giant parathyroid adenomas. Giant parathyroid adenomas are in fact rarely encountered among patients with primary hyperparathyroidism. They are believed to have distinct clinical and biochemical features related to specific genomic alterations. We chanced to manage a unique and possibly the first case of giant parathyroid adenoma (6 cm diameter and weighing 20 g) presenting with recurrent episodes of pancreatitis and discuss its surgical management with an added emphasis on the role of nuclear imaging in its preoperative localization. Our case demonstrates that clinicians should have a high index of suspicion of primary hyperparathyroidism in patients presenting with recurrent episodes of pancreatitis. Timely diagnosis, appropriate preoperative localization techniques, which would include a parathyroid scintigraphy and a focused surgical intervention are crucial to resolve complications and improve outcomes.

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“…[ 11 ] There have been a few reports for the use of 11 C-methionine PET as a promising imaging modality for localizing parathyroid adenomas. [ 12 ]…”

Section: Discussionmentioning

confidence: 99%

A rare case of giant parathyroid adenoma presenting with recurrent episodes of pancreatitis

Raghunandan

Ramshankar

2016

Indian J Nucl Med

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“…The results regarding the use of 11 C-methione have been predominantly positive, although the study by Hermann et al showed a lower sensitivity compared to US and SPECT [29,30]. One of the most recent studies by Lenschow et al investigated its use in six patients with negative SPECT-CT and was able to correctly localize the adenoma in 5/6 patients [31]. Also, 11 C-methionine has proven to be useful in patients with renal failure and negative sestamibi scanning [32].…”

Section: Spect-ct Before Usmentioning

confidence: 93%

Enabling minimal invasive parathyroidectomy for patients with primary hyperparathyroidism using Tc-99m-sestamibi SPECT–CT, ultrasound and first results of 18F-fluorocholine PET–CT

Kluijfhout

Vorselaars

Vriens

et al. 2015

European Journal of Radiology

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“…The mean volume of detected abnormal glands has been reported as 3.5 cm 3 , while the mean volume of missed glands is 1.4 cm 3 [85, 86]. …”

Section: Diagnosis and Imagingmentioning

confidence: 99%

Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus

et al. 2016

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The purpose of this review is to assess the most recent evidence in the management of primary hyperparathyroidism (PHPT) and provide updated recommendations for its evaluation, diagnosis and treatment. A Medline search of "Hyperparathyroidism. Primary" was conducted and the literature with the highest levels of evidence were reviewed and used to formulate recommendations. PHPT is a common endocrine disorder usually discovered by routine biochemical screening. PHPT is defined as hypercalcemia with increased or inappropriately normal plasma parathyroid hormone (PTH). It is most commonly seen after the age of 50 years, with women predominating by three to fourfold. In countries with routine multichannel screening, PHPT is identified earlier and may be asymptomatic. Where biochemical testing is not routine, PHPT is more likely to present with skeletal complications, or nephrolithiasis. Parathyroidectomy (PTx) is indicated for those with symptomatic disease. For asymptomatic patients, recent guidelines have recommended criteria for surgery, however PTx can also be considered in those who do not meet criteria, and prefer surgery. Non-surgical therapies are available when surgery is not appropriate. This review presents the current state of the art in the diagnosis and management of PHPT and updates the Canadian Position paper on PHPT. An overview of the impact of PHPT on the skeleton and other target organs is presented with international consensus. Differences in the international presentation of this condition are also summarized.

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Preoperative ¹¹C‐Methionine PET/CT Enables Focussed Parathyroidectomy in MIBI‐SPECT Negative Parathyroid Adenoma

Abstract: Met-PET/CT raises the rate of correctly localized single parathyroid adenomas in patients with negative cUS and MIBI-SPECT/CT and increases the number of focussed surgical approaches.

Cited by 20 publications

References 39 publications

A rare case of giant parathyroid adenoma presenting with recurrent episodes of pancreatitis

A rare case of giant parathyroid adenoma presenting with recurrent episodes of pancreatitis

Enabling minimal invasive parathyroidectomy for patients with primary hyperparathyroidism using Tc-99m-sestamibi SPECT–CT, ultrasound and first results of 18F-fluorocholine PET–CT

Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus

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Preoperative 11C‐Methionine PET/CT Enables Focussed Parathyroidectomy in MIBI‐SPECT Negative Parathyroid Adenoma

Abstract: Met-PET/CT raises the rate of correctly localized single parathyroid adenomas in patients with negative cUS and MIBI-SPECT/CT and increases the number of focussed surgical approaches.

Cited by 20 publications

References 39 publications

A rare case of giant parathyroid adenoma presenting with recurrent episodes of pancreatitis

A rare case of giant parathyroid adenoma presenting with recurrent episodes of pancreatitis

Enabling minimal invasive parathyroidectomy for patients with primary hyperparathyroidism using Tc-99m-sestamibi SPECT–CT, ultrasound and first results of 18F-fluorocholine PET–CT

Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus

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Preoperative ¹¹C‐Methionine PET/CT Enables Focussed Parathyroidectomy in MIBI‐SPECT Negative Parathyroid Adenoma