Preoperative Serum Hyaluronic Acid Level as a Good Predictor of Posthepatectomy Complications

Abstract

Our findings indicate that the preoperative serum HA level is a good predictor of postoperative complications in patients who undergo hepatectomy for injured liver disease.

Prediction of Indocyanine Green Retention Rate at 15 Minutes by Correlated Liver Function Parameters before Hepatectomy

“…The findings of our study and those of others showed that serum HA concentrations correlated inversely with measurements of functional liver reserve and the degree of hepatic fibrosis, suggesting that measuring the HA level might be useful for monitoring liver damage or predicting postoperative complications after hepatic resection [18,23].…”

“…Damage to the hepatic endothelial cells results in a high serum HA level [18,23], which is thought to be a marker of hepatic fibrosis. If endothelial cell function in the injured liver deteriorates [23], the serum HA level could be a useful marker of nonparenchymal liver cell function.…”

“…The remaining three parameters used for the multiple linear regression analysis were HA level and the two 99m-Tc GSA liver scintigraphy results, which were reliable parameters that have already been applied as referral parameters with ICGR15 [11,18].…”

“…To measure ICGR15, indocyanine green (ICG) was injected intravenously at a dose of 0.5 mg/kg body weight with the 15-minute retention rate measured by a photopiece applied to the fingertip (RK-1000, Sumitomo Electric, Tokyo, Japan) without blood sampling [7,8,11]. Peripheral blood samples were also collected before meals for analysis of hyaluronic acid (HA), a marker of hepatic fibrosis and endothelial cell function in hepatic sinusoids [18]. Blood samples were centrifuged at 3000 rpm for 15 min, and serum was stored at -80C.…”

Can preoperative diffusion-weighted MRI predict postoperative hepatic insufficiency after curative resection of HBV-related hepatocellular carcinoma? A pilot study

“…The primary end point was the development of postoperative hepatic insufficiency. Postoperative hepatic insufficiency was defined as persistent hyperbilirubinemia (total bilirubin level N5 mg/dl for more than 5 days after surgery) or postoperative death without other causes [19,20]. The secondary end points were the performance of ADC values in the assessment of liver fibrosis, the reliability of ADC values between the two hepatic lobes, and the intra-and interobserver reliability of ADC values.…”