Preoperative serum carbohydrate antigen 125 level is an independent negative prognostic marker for overall survival in colorectal cancer

Yang, Xueqin; Li, Yan; Chen, Chuang; Peng, Changhong; Liu, Shaoping; Liu, Yang

doi:10.1007/s12032-010-9518-z

Cited by 22 publications

(21 citation statements)

References 20 publications

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“…In the present study, serum CA242 status was significantly associated with the presence of T and N stages, nerve invasion and pTNM staging. This is consistent with previous studies that revealed that CA242 was a prognostic factor in patients with CRC (42). Similarly, in the present study serum CA19-9 and CA125 levels were significantly associated with lymph node metastasis and pTNM staging.…”

Section: Associations Between Biomarkers and Clinical Stage Of Diseasesupporting

confidence: 93%

Clinical significance and diagnostic value of serum NSE, CEA, CA19‑9, CA125 and CA242 levels in colorectal cancer

Hai

Shen

et al. 2020

Oncol Lett

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The present study investigated the value of combinations of five specific tumor biomarkers for the diagnosis of colorectal cancer (CRC): Neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), cancer antigen (CA)19-9, CA125 and CA242. Associations between these markers and clinicopathological characteristics (including the Tumor-Node-Metastasis stage) were also assessed. Serum levels of the 5 markers were compared between 358 patients with CRC and 298 healthy individuals (CRC and control group, respectively). The NSE concentration of the CRC group was significantly higher compared with the control. Furthermore, patients at clinical stage III+IV exhibited significantly higher NSE levels compared with those at stage I+II. The serum NSE level of N + patients was significantly higher compared with the Ngroup, and the NSE level of M 1 patients was significantly compared with the M 0 group. NSE level was also significantly associated with tumor stage, lymph node metastasis, distant metastasis and hematochezia. The area under the receiver operating characteristic curve (AUC) for NSE in CRC was 0.766, which was significantly higher than that of the other four markers, which ranged from 0.560-0.682. The AUC of NSE, CEA, CA19-9, CA125, CA242 combined was significantly higher compared with any of the markers individually (range, 0.796-0.858). Therefore, serum NSE may be a good clinical tool for the auxiliary diagnosis of colorectal cancer. Besides, the combination of NSE, CEA, CA19-9, CA125 and CA242 was significantly more sensitive compared with NSE alone. Thus, the combined detection of the 5 tumor markers may be more useful for the diagnosis of CRC.

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Section: Associations Between Biomarkers and Clinical Stage Of Diseasesupporting

confidence: 93%

Clinical significance and diagnostic value of serum NSE, CEA, CA19‑9, CA125 and CA242 levels in colorectal cancer

Hai

Shen

et al. 2020

Oncol Lett

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“…30 Studies have confirmed that preoperative serum CA125 is an independent prognostic factor for overall survival of colon cancer, rather than CEA. 31 Serum AFP is the most common tumor marker for HCC, following with elevated serum AFP among 2/3 of HCC patients. A markedly elevated serum AFP level usually indicates a poor prognosis of HCC.…”

Section: Discussionmentioning

confidence: 99%

<p>Prognostic Significance of Elevated Preoperative Serum CA125 Levels After Curative Hepatectomy for Hepatocellular Carcinoma</p>

Huang¹,

Zeng²,

Liu³

et al. 2020

OTT

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The aim of this study was to investigate predictive and prognostic significance of elevated carbohydrate antigen 125 (CA125) serum level preoperatively. Methods: A total of 3440 HCC patients were retrospectively enrolled into this study, and all of them underwent curative hepatectomy. The clinical and pathological variables together with CA125, AFP serum level were collected at diagnosis and postoperative care stages. A chi-square test was used to compare the differences between variables. Overall survival (OS) and recurrence-free survival (RFS) were measured with the Kaplan-Meier method. To estimate prognostic factors, a multivariate Cox regression analysis was performed. Results: Of the 3440 enrolled patients, 409 (11.9%) exhibited elevated preoperative serum CA125 level, and high preoperative serum CA125 level was significantly associated with younger age, female, higher ALBI grade, higher serum AFP level, blood transfusion, more operative bleeding loss, larger tumor size, multiple tumor, increased macro-or microvascular invasion, Edmondson grade III-IV, absence of tumor capsular, satellite nodules, liver cirrhosis, more advanced TNM stages and BCLC stages. HCC patients with high preoperative serum CA125 level usually had a shorter OS rate and experienced a higher probability of recurrence than those with normal preoperative serum level of CA125 (p<0.0001). The multivariate analysis suggested that elevated serum CA125 level serves as an independent predictor of OS and RFS in HCC patients after surgical resection. Conclusion: Elevated preoperative serum CA125 correlated with many malignant characterizations of HCC and served as an independent prognostic factor of OS and RFS.

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“…Basbug et al (2011) evaluated the prognostic value of CEA and CA 19-9 in colorectal cancer patients and found a statistically significant relationship between positivity for both tumor markers and advanced TNM stage. Similarly, Xue-Qin Yang et al (2001) investigated the prognostic importance of preoperative CEA, CA 19-9, and CA 125 values in colorectal cancer patients and found a correlation between increased preoperative values of these parameters and advanced stage. Most of these studies appear to indicate a significant correlation between CEA and advanced stage, while only some of them show a relationship between CA 19-9 and advanced stage.…”

Section: Discussionmentioning

confidence: 99%

CEA and CA 19-9 are Still Valuable Markers for the Prognosis of Colorectal and Gastric Cancer Patients

Şişik¹,

Kaya²,

Baş³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: The purpose of this study was to assess the predictive effect of preoperative CEA and CA 19-9 levels on the prognosis of colorectal and gastric cancer patients. Materials and Methods: CEA and CA 19-9 were evaluated preoperatively in patients undergoing surgery for colorectal cancer (n=116) and gastric cancer (n=49). Patients with CEA levels <5 ng/mL were classified as CEA Group 1, 5-30 ng/mL as CEA Group 2 and >30 ng/ mL were classified as CEA Group 3. Similarly the patients with a CA 19-9 level <35 U/mL were classified as CA 19-9 Group 1, with 35-100 U/mL as Group 2 and with >100 U/mL as Group and 3. TNM stages and histologic grades were noted according to histopathological reports. Patients with a TNM grade 0 or 1 were classified as Group A, TNM grade 2 patients constituted Group B and TNM grade 3 and 4 patients constituted Group C. Demographic characteristics, tumor locations and blood types of the patients were all recorded and these data were compared with the preoperative CEA and CA19-9 values. Results: A significant correlation between CA 19-9 levels (>100 U/mL) and TNM stage (in advanced stages) was determined. We also determined a significant correlation between TNM stages and positive vlaues for both CEA and CA 19-9 in colorectal and gastric cancer patients. In comparison between CEA and CA 19-9 levels and age, gender, tumor location, ABO blood group, and tumor histologic grade, no significant correlation was found. Conclusions: Positive levels of both CEA and CA 19-9 can be considered to indicate an advanced stage in colorectal and gastric cancer patients.

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Preoperative serum carbohydrate antigen 125 level is an independent negative prognostic marker for overall survival in colorectal cancer

Cited by 22 publications

References 20 publications

Clinical significance and diagnostic value of serum NSE, CEA, CA19‑9, CA125 and CA242 levels in colorectal cancer

Clinical significance and diagnostic value of serum NSE, CEA, CA19‑9, CA125 and CA242 levels in colorectal cancer

<p>Prognostic Significance of Elevated Preoperative Serum CA125 Levels After Curative Hepatectomy for Hepatocellular Carcinoma</p>

CEA and CA 19-9 are Still Valuable Markers for the Prognosis of Colorectal and Gastric Cancer Patients

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