Preoperative serum albumin level is a prognostic indicator for adenocarcinoma of the gastric cardia

Lien, Yung Chang; Hsieh, Chih Cheng; Wu, Yu Chung; Hsu, Han Shui; Hsu, Wen Hu; Wang, Liang Shun; Huang, Min Hsiung; Huang, Bin

doi:10.1016/j.gassur.2004.09.033

Cited by 153 publications

(100 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In accordance with other studies (8,24), the present study showed that elevated CRP correlated with poorer prognosis in patients with gastric cancer and peritoneal seeding. Lien et al reported that preoperative serum albumin levels are associated with resectability and survival rates in patients with gastric cancer (26). Serum albumin is not only an indicator used to recognize the nutritional status of patients, but is also useful for predicting the prognostic outcome of cancer patients (5,27).…”

Section: Discussionmentioning

confidence: 99%

Glasgow Prognostic Score is superior to ECOG PS as a prognostic factor in patients with gastric cancer with peritoneal seeding

et al. 2018

View full text Add to dashboard Cite

Abstract. The Glasgow Prognostic Score (GPS) has been shown to be associated with survival rates in patients with advanced cancer. The present study aimed to compare the GPS with the Eastern Cooperative Oncology Group Performance Status (ECOG PS) in patients with gastric cancer with peritoneal seeding. For the investigation, a total of 384 gastric patients with peritoneal metastasis were retrospectively analyzed. Patients with elevated C-reactive protein (CRP; >10 mg/l) and hypoalbuminemia (<35 mg/l) were assigned a score of 2. Patients were assigned a score of 1 if presenting with only one of these abnormalities, and a score of 0 if neither of these abnormalities were present. The clinicopathologic characteristics and clinical outcomes of patients with peritoneal seeding were analyzed. The results showed that the median overall survival (OS) of patients in the GPS 0 group was longer, compared with that in the GPS 1 and GPS 2 groups (15.50, vs. 10.07 and 7.97 months, respectively; P<0.001). No significant difference was found between the median OS of patients with a good performance status (ECOG <2) and those with a poor (ECOG ≥2) performance status (13.67, vs. 11.80 months; P= 0.076). In the subgroup analysis, the median OS in the GPS 0 group was significantly longer, compared with that in the GPS 1 and GPS 2 groups, for the patients receiving palliative chemotherapy and patients without palliative chemotherapy. Multivariate survival analysis demonstrated that CA19-9, palliative gastrectomy, first-line chemotherapy and GPS were the prognostic factors predicting OS. In conclusion, the GPS was superior to the subjective assessment of ECOG PS as a prognostic factor in predicting the outcome of gastric cancer with peritoneal seeding.

show abstract

Section: Discussionmentioning

confidence: 99%

Glasgow Prognostic Score is superior to ECOG PS as a prognostic factor in patients with gastric cancer with peritoneal seeding

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Thus, hypoalbuminemia and high levels of CRP may be regarded as a paraneoplastic phenomenon. Moreover, hypoalbuminemia is significantly associated with poor prognosis in patients with gastric cancer [26,27].…”

Section: Discussionmentioning

confidence: 99%

Survival analysis of patients with stage IV gastric cancer following palliative surgery based on inflammation-based prognostic score

Matsubara¹,

Hirahara²,

Takanashi³

et al. 2017

Gastroenterol Hepatol Endosc

View full text Add to dashboard Cite

Objective: The Glasgow Prognostic Score (GPS) has been demonstrated to be a useful prognostic factor for various tumors. The aim of the current study was to clarify the significance of the GPS for predicting postoperative survival of patients with stage IV gastric cancer after receiving palliative surgery. Summary of background data:Generally stage IV gastric cancer is not considered for curative surgery. However, palliative surgery is often required to improve the quality of life of patients.Methods: 51 consecutive patients with stage IV gastric cancer was performed the association between GPS, clinicopathological factors and overall survival was assessed.Results: Peritoneal lavage cytology (CY), P0CY1 (no peritoneal dissemination and CY positive), surgical treatment, operative time and curability factors were correlated well with the GPS score. The number of metastatic sites (1 vs. ≧2), curability (R0, R1 vs. R2) and GPS score (0, 1 vs. 2) were found to be the independent prognostic factor. The prognosis of patients with a high GPS was significantly poor. Conclusion:In patients with a GPS of 2, surgical treatment offered only few benefits to the patients and, thus, less invasive treatment should be recommended for these patients.

show abstract

“…Mide kanserinin cerrahi tedavisinde total gastrektomi ile subtotal gastrektominin karşılaştı-rıldığı bir çalışmada sağ kalım açısından fark bulunmamıştır (19). Bunun yanı sıra ameliyat öncesi serum albümin düzey düşüklüğünün ameliyat sonrası sağ kalım üzerine kötü prognostik faktör olduğunu bildiren çalışmalar da vardır (20,21). Bizim çalışmamızda morbidite %17.6 (n=89) ve erken dönem mortalite oranı-mız %5.5 (n=28) olarak hesaplanmıştır.…”

Section: Discussionunclassified

Surgery in the Gastric Cancer: 504 Cases

Kısaoğlu¹,

Özoğul²,

Yıldırgan³

et al. 2014

Turk J Bioch

View full text Add to dashboard Cite

Objective: Gastric cancer is the second most common cause of cancer-related deaths. It is mostly seen between the ages of 50-70 years. In our study, we aimed to present our 11 years of experience about surgical treatment of gastric cancer. Method: In our medical faculty hospital between January 2000 and December 2010, a total of 504 patients, who operated with the diagnosis of gastric cancer, were analyzed retrospectively. Morbidity and mortality rate were evaluated according to type of operations and risk factors. Results: 182 of the patients (mean age 62.4 years) were female (36.1%) and 322 (63.9%) were male. The tumor location was antrum in the 202 (40.1%) patients, corpus in the 107 (21.2%) patients, cardia and fundus in the 195 (38.7%) patients. Distal subtotal gastrectomy was done 160 (%31.7) of the patients, total gastrectomy was done 204 (%40.5) of the patients and 140 (%27.8) of the patients were considered to be nonresectable because of reasons such as the liver metastasis, peritoneal dissemination and invasion of adjacent organs. Morbidity was found to be %17.6 (n=89) and early mortality rate was found as %5.5 (n=28), respectively. Conclusion: We found that gastric cancer patients are diagnosed at advanced stage in our region. Especially people who are at risk and have symptoms should be undertaken to screening programs such as endoscopy. In patients with gastric cancer, there is a relationship between advanced age, hypoalbuminemia, and serious co-morbidity with surgical mortality. AnahtarKelimeler: Mide Kanseri, cerrahit tedavi, mortalite.

show abstract

Preoperative serum albumin level is a prognostic indicator for adenocarcinoma of the gastric cardia

Cited by 153 publications

References 18 publications

Glasgow Prognostic Score is superior to ECOG PS as a prognostic factor in patients with gastric cancer with peritoneal seeding

Glasgow Prognostic Score is superior to ECOG PS as a prognostic factor in patients with gastric cancer with peritoneal seeding

Survival analysis of patients with stage IV gastric cancer following palliative surgery based on inflammation-based prognostic score

Surgery in the Gastric Cancer: 504 Cases

Contact Info

Product

Resources

About