Preoperative Risk Score and Prediction of Long-Term Outcomes after Hepatectomy for Intrahepatic Cholangiocarcinoma

Abstract

Postsurgical long-term outcomes could be predicted using a composite weighted scoring system based on preoperative clinical parameters. The preoperative risk model can be used to inform patient to provider conversations and expectations before operation.

A novel online prognostic tool to predict long‐term survival after liver resection for intrahepatic cholangiocarcinoma: The “metro‐ticket” paradigm

“…While ICC is an aggressive tumor with generally poor prognosis following surgical resection, the long‐term prognosis can vary significantly . Accurate prognostication of long‐term survival remains important for clinicians to guide treatment decision‐making, as well as for patients to understand their prognosis.…”

Discordance in prediction of prognosis among patients with intrahepatic cholangiocarcinoma: A preoperative vs postoperative perspective

“…For select patients who undergo curative‐intent surgery, OS generally remains poor with nearly two‐thirds of patients recurring soon after surgery . As such, several prognostic tools have been designed to help practitioners inform patients regarding the long‐term benefit of surgery, as well as to help determine the role of surgical resection as part of multidisciplinary treatment strategy . To date, however, these strategies have focused on the development of risk prediction models at one point in time—either solely based on preoperative factors or through the additional incorporation of postoperative factors.…”

“…The clinical utility of such risk prediction models is limited in the preoperative setting, as some characteristics are only available after the patient has elected to undergo resection. As such, Sasaki et al proposed a preoperative risk tool to predict long‐term survival following resection of ICC. In this study, preoperative albumin levels, as well as tumor and SIR markers were used to predict postsurgical long‐term outcomes .…”

“…As such, Sasaki et al proposed a preoperative risk tool to predict long‐term survival following resection of ICC. In this study, preoperative albumin levels, as well as tumor and SIR markers were used to predict postsurgical long‐term outcomes . In a separate study, Yoh et al proposed a preoperative prognostic grading system, which used biomarkers such as NLR, C‐reactive protein (CRP), and CA19‐9 levels, that demonstrated higher accuracy for survival prediction than the AJCC staging systems.…”

“…The ideal goal of a preoperative prognostic model is to achieve a similar prediction compared with the postoperative prognostic model. Current preoperative prognostic models have not been evaluated “head‐to‐head” relative to postoperative prognostic models . While many parameters are often comparable, including tumor size, number of tumors, and tumor marker levels, patient prognosis may sometimes be disparate in the preoperative and postoperative setting.…”