Preoperative PSA level significantly associated with interval to biochemical progression after radical retropubic prostatectomy

Gonzalez, Christopher; Roehl, Kimberly A.; Antenor, JoAnn; Blunt, Lynn W.; Han, Misop; Catàlona, William J.

doi:10.1016/j.urology.2004.05.019

Cited by 21 publications

(12 citation statements)

References 17 publications

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“…A clinical stage was positively correlated with several parameters. First of all, with the preoperative serum PSA levels < (0.334) and the Gleason score (0.317) with a statistical significance, which is consistent with the data from the literature 39,43,48 . The correlation analysis within the parameters of neuroendocrine differentiation showed that the most cells were positive for synaptophysin, with the significant level and high correlation (0.751), which gave it the importance of the most sensitive NED marker in this study.…”

Section: Discussionsupporting

confidence: 90%

Correlation of focal neuroendocrine differentiation in prostate cancer with the parameters of predictive value

Mijović¹,

Ćorac²,

Smiljic³

et al. 2019

VOJNOSANIT PREGL

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Background/Aim. Neuroendocrine (NE) cells are one of the epithelial populations in the prostate. It is well-known that the focal neuroendocrine differentiation (FNED) in prostate cancer (PC) is an aggressive subtype that most commonly evolves from preexisting PC which does not respond to hormone therapy (androgen independed PC). The incidence and clinical importance of FNED in PC is not clearly understood because of conflicting results in the studies, and evaluation of FNED is not routinely performed in clinical practice. The aim of the present study is to determine the importance of FNED presence in the examined prostate changes with special reference to the relationship of FNED degree in PC with some parameters of predictive value [Gleason score, preoperative serum total prostata specific antigen (PSA) value, tumor volume and tumor stage]. Methods. The study included the biopsy material from 100 untreated consecutive prostate pathological changes: 70 PC, 20 prostatic intraepithelial neoplasia (PIN) and 10 benign prostatic hyperplasia (BPH). The patients with PIN and BPH were the control groups. A block containing part of

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Section: Discussionsupporting

confidence: 90%

Correlation of focal neuroendocrine differentiation in prostate cancer with the parameters of predictive value

Mijović¹,

Ćorac²,

Smiljic³

et al. 2019

VOJNOSANIT PREGL

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“…Therefore, the same techniques used in this study can be readily transferred to the clinical setting at the time of prostate biopsy. Previously reported blood or tissue biomarker analysis have not approached the sensitivity and specificity of the prediction achieved by the model described here (31–37). …”

Section: Discussionmentioning

confidence: 73%

Chemokine Markers Predict Biochemical Recurrence of Prostate Cancer following Prostatectomy

Blum

Koyama

M’Koma

et al. 2008

Clinical Cancer Research

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Purpose: Stratifying patients who have a high risk of prostate cancer recurrence following prostatectomy can potentiate the use of adjuvant therapy at an early stage. Inflammation has emerged as a mediator of prostate cancer metastatic progression. We hypothesized that chemokines can be biomarkers for distinguishing patients with high risk for biochemical recurrence of prostate cancer. Experimental Design: In a nested case-control study, 82 subjects developed biochemical recurrence within 5 years of prostatectomy. Prostate tissues from 98 age-matched subjects who were recurrence-free following prostatectomy in the same period were the controls. A high-throughput lectin-based enrichment of prostate tissue enabled multiplex ELISA to identify the expression of three chemokines to discriminate the two patient populations. Results: The expression of CX3CL1 and IL-15 in prostate tissue was associated with 5-year biochemical recurrence-free survival following prostatectomy. However, the expression of chemokine ligand 4 (CCL4) was associated with biochemical recurrence. Multivariable logistic regression model combining preoperative prostate-specific antigen, Gleason score, surgical margin, and seminal vesicle status with the three chemokines doubled the specificity of prediction at 90% sensitivity compared with use of the clinicopathologic variables alone (P < 0.0001).Survival analysis yielded a nomogram that supported the use of CX3CL1, IL-15, and CCL4 in predicting 1-, 3-, and 5-year recurrence-free survival after prostatectomy. Conclusions: Each of the three chemokines can serve as independent predictors of biochemical recurrence. However, the combination of chemokine biomarkers plus clinicopathologic variables discriminated prostatectomy subjects for the probability of biochemical recurrence significantly better than clinicopathologic variables alone.

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“…In the clinic, serum PSA measurements are being widely used to screen for PCA [32,33]. Several studies have reported the usefulness of serum PSA as a follow-up marker for local recurrence and/or distant disease in the patients after radical prostatectomy, radiation and hormonal therapy [34,35].…”

Section: Discussionmentioning

confidence: 99%

In vitro and in vivo modulation of testosterone mediated alterations in apoptosis related proteins by [6]‐gingerol

Shukla¹,

Prasad

Tripathi

et al. 2007

Molecular Nutrition Food Res

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Ginger (Zingiber officinale, Zingiberaceae) has been widely used as a dietary spice, and as a traditional oriental medicine. The rhizome of ginger contains pungent vanillyl ketones, including [6]-gingerol and [6]-paradol, and have been credited with therapeutic and preventive health benefits, including anti-cancer activity. Prostate cancer is an attractive target for chemoprevention because of its ubiquity, treatment-related morbidity, long latency between premalignant lesions and clinically evident cancer, and defined molecular pathogenesis. Here we are reporting the modulatory effects of [6]-gingerol on testosterone-induced alterations on apoptosis related proteins in both in vitro, androgen sensitive LNCaP cells and in vivo, ventral prostate of Swiss albino mice. [6]-gingerol treatment resulted apoptosis in LNCaP cells, as indicated by depolarization of mitochondrial membrane potential, increase in sub G1 cell population by flow cytometry and the appearance of DNA laddering pattern in agarose gel electrophoresis. Results of western blot analysis showed that [6]-gingerol upregulated the testosterone depleted levels of p53 in mouse prostate and upregulated its downstream regulator Bax and further activated Caspase-9 and Caspase-3 in both LNCaP cells and in mouse prostate. We also found downregulation of testosterone induced antiapoptotic proteins, Bcl-2 and Survivin expression by [6]-gingerol in both LNCaP cells and in mouse ventral prostate. Thus, [6]-gingerol shows its protective effects in both in vivo and in vitro prostate cancer models by modulation of proteins involved in apoptosis pathway.

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Preoperative PSA level significantly associated with interval to biochemical progression after radical retropubic prostatectomy

Cited by 21 publications

References 17 publications

Correlation of focal neuroendocrine differentiation in prostate cancer with the parameters of predictive value

Correlation of focal neuroendocrine differentiation in prostate cancer with the parameters of predictive value

Chemokine Markers Predict Biochemical Recurrence of Prostate Cancer following Prostatectomy

In vitro and in vivo modulation of testosterone mediated alterations in apoptosis related proteins by [6]‐gingerol

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