Preoperative predictive model and nomogram for disease recurrence following radical nephroureterectomy for high grade upper tract urothelial carcinoma

Freifeld, Yuval; Ghandour, Rashed; Singla, Nirmish; Woldu, Solomon L.; Clinton, Timothy; Kulangara, Rohan; Bagrodia, Aditya; Peng, Jiaqi; Petros, Firas; Raman, Jay D.; Robyak, Haley; Yan, Jingsheng; Zhu, Hong; Rapoport, L.; Lotan, Yair; Margulis, Vitaly

doi:10.1016/j.urolonc.2019.06.009

Cited by 22 publications

(12 citation statements)

References 22 publications

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“…A positive Ki-67 expression has been associated with adverse pathological features and poor recurrence-and cancerfree survival in patients with UTUC receiving nephroureterectomy [14][15][16][17][18]. Among the various biomarkers examined previously, Ki-67 appears to be the most potential biomarker with its cell proliferation characteristic [10,11,19]. In our previous study, we found that a PD-L1 combined positive score (CPS) ≥ 10 in UTUC was associated with worse CSS and overall survival (OS) [20].…”

Section: Introductionmentioning

confidence: 98%

“…Although UTUC has been indicated to have poor prognosis and oncological outcomes, accurate prognostic factors for UTUC are unavailable. Many studies have attempted to develop a prognostic model based on postoperative pathological or preoperative parameters; however, novel biomarkers and predictive prognostic models remain under debate [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the Prognostic Value of Ki-67 and Programmed Cell Death Ligand-1 in Patients with Upper Tract Urothelial Carcinoma

Tsai

Chiang

Chen

et al. 2021

JCM

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We retrospectively enrolled 102 patients with upper tract urothelial carcinoma (UTUC) who underwent radical nephroureterectomy to examine the prognostic value of Ki-67 and programmed cell death ligand-1 (PD-L1). Then, we performed PD-L1 and Ki-67 immunohistochemical staining on whole tissue sections. The cut-off value of PD-L1 positivity was a combined positive score (CPS) ≥10 and the Ki-67 overexpression was 20%. Among the 102 patients, 16.7% and 48.0% showed positive PD-L1 expression and Ki-67 overexpression, respectively. A CPS ≥10 was significantly associated with a higher pathological T stage (p = 0.049). In addition, Ki-67 overexpression was significantly associated with a pathological T stage ≥ 2 (p = 0.027) and tumour necrosis (p = 0.016). In the multivariable analysis, a positive PD-L1 expression was significantly correlated with worse cancer-specific survival (HR = 3.66, 95% CI =1.37−9.77, p = 0.01). However, there was no predictive value using a combination of PD-L1 expression and Ki-67 overexpression as a prognostic predictor. Compared with Ki-67 overexpression, a positive PD-L1 expression with CPS ≥ 10 was a stronger independent prognostic factor for CSS in patients with UTUC.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Comparison of the Prognostic Value of Ki-67 and Programmed Cell Death Ligand-1 in Patients with Upper Tract Urothelial Carcinoma

Tsai

Chiang

Chen

et al. 2021

JCM

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“…Any disagreement was resolved by consensus. Finally, 13 papers [ 7 , 11 , 22 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ] were included in this study.…”

Section: Methodsmentioning

confidence: 99%

Estimated Glomerular Filtration Rate as a Prognostic Factor in Urothelial Carcinoma of the Upper Urinary Tract: A Systematic Review and Meta-Analysis

Kim

Yuk

Jeong

et al. 2021

JCM

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Preoperative renal function is associated with worse outcomes in patients undergoing radical nephroureterectomy (RNU). The purpose of this systemic review and meta-analysis was to determine the association of preoperative renal function with oncological outcome in patients who underwent RNU. We searched articles published up to March 2021 in PubMed, Scopus, and Embase by combining “urothelial carcinoma”, “radical nephroureterectomy”, and “estimated glomerular filtration rate”. We also manually screened the reference list for publications following general guidelines recommended by the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. The relationship between preoperative renal function and survival was expressed as overall survival (OS), progression-free survival (PFS), and cancer-specific survival (CSS). This review and meta-analysis included 13 studies involving a total of 4668 patients who received RNU. Pooled analysis showed significant negative association of preoperative renal function with PFS (HR: 1.51, 95% CI: 1.23–1.80, p < 0.00001), CSS (HR: 1.63, 95% CI: 1.38–1.92, p < 0.00001), and OS (HR: 1.22, 95% CI: 1.10–1.35, p < 0.00001). Patients with upper tract urothelial carcinoma (UTUC) who received RNU showed a significant negative association of preoperative renal function with survival.

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“…68 Lastly, a multi-center database was used to develop a preoperative nomogram to help predict disease recurrence to better select patients who can most benefit from RNU. 69 There exist 5 different postoperative nomograms. They can help to predict survival rates based on standard pathological features, [70][71][72][73][74] which can be helpful for postoperative follow-up and counseling.…”

Section: Clinical Nomograms and Predictive Toolsmentioning

confidence: 99%

<p>Optimal Management of Upper Tract Urothelial Carcinoma: Current Perspectives</p>

Leow

Liu

Tan

et al. 2020

OTT

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Preoperative predictive model and nomogram for disease recurrence following radical nephroureterectomy for high grade upper tract urothelial carcinoma

Cited by 22 publications

References 22 publications

Comparison of the Prognostic Value of Ki-67 and Programmed Cell Death Ligand-1 in Patients with Upper Tract Urothelial Carcinoma

Comparison of the Prognostic Value of Ki-67 and Programmed Cell Death Ligand-1 in Patients with Upper Tract Urothelial Carcinoma

Estimated Glomerular Filtration Rate as a Prognostic Factor in Urothelial Carcinoma of the Upper Urinary Tract: A Systematic Review and Meta-Analysis

<p>Optimal Management of Upper Tract Urothelial Carcinoma: Current Perspectives</p>

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