Estimated Glomerular Filtration Rate as a Prognostic Factor in Urothelial Carcinoma of the Upper Urinary Tract: A Systematic Review and Meta-Analysis

Kim, Min-Hyuk; Yuk, Hyeong Dong; Jeong, Chang Wook; Kwak, Cheol; Kim, Hyeon Hoe; Ku, Ja Hyeon

doi:10.3390/jcm10184155

Cited by 4 publications

(2 citation statements)

References 45 publications

(68 reference statements)

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“…In a meta-analysis of over 4,000 patients by Kim et al , there was a significant negative association between preoperative renal function and survival ( 59 ). Another large meta-analysis noted similar findings after dividing patients into two groups: those with chronic kidney disease (CKD; eGFR <60 mL/min/1.73 m 2 ) and those with normal kidney function.…”

Section: Factors Associated With Oncologic Outcomesmentioning

confidence: 99%

Oncologic outcomes following radical nephroureterectomy for upper tract urothelial carcinoma: a literature review

Grob,

Rogers,

Pandolfo

et al. 2023

Transl Androl Urol

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Background and Objective Radical nephroureterectomy (RNU) represents the gold standard treatment for non-metastatic upper tract urothelial cancer. We sought to provide a comprehensive review of reported oncologic outcomes of the RNU procedure and of factors that might impact these outcomes. Methods A non-systematic review of the literature was conducted by performing an electronic literature search using PubMed with “radical nephroureterectomy” and “oncologic outcomes” as free text search terms. Both original articles and systematic reviews were considered. Search was limited to articles in English that were published in the last 20 years. Key Content and Findings Open and laparoscopic RNU offer comparable oncologic outcomes. In more recent years, the discussion has de facto shifted towards the “oncological safety” of robotic RNU, which also seems to offer comparable oncologic outcomes. Several studies have looked at the impact of different treatment-, patient- and tumor-related factors. Among treatment-related factors, attention has been given to diagnostic ureteroscopy and the risk of intravesical recurrence. Surgical wait time and perioperative blood transfusion have also been studied. Perioperative chemotherapy, specifically adjuvant therapy, was shown to improve survival. Among patient-related factors, baseline chronic kidney disease, diabetes mellitus, body mass index, and systemic inflammation have gained recent attention. Some tumor related factors, such as stage, grade, location, and multifocality may negatively impact survival outcomes. Lymphovascular invasion and histologic variants are clinically significant pathological findings. Conclusions RNU is a procedure with measured long-term oncologic outcomes. Minimally invasive techniques have gained an established role as they seem to offer comparable oncologic “safety”, although special attention is needed in relation to the method of bladder cuff excision. Robotic RNU is gaining popularity, and while evidence remains limited, the current literature supports the oncologic safety of this procedure. Several factors, which can be categorized as treatment-related, patient-related, and tumor-related, might impact the oncologic outcomes of UTUC patients undergoing RNU. These factors can provide crucial information to stratify patients based on their relative risk of disease recurrence and mortality which may guide clinical decision-making.

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Section: Factors Associated With Oncologic Outcomesmentioning

confidence: 99%

Oncologic outcomes following radical nephroureterectomy for upper tract urothelial carcinoma: a literature review

Grob,

Rogers,

Pandolfo

et al. 2023

Transl Androl Urol

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show abstract

“…Плоскоклеточный рак является наиболее редким гистологическим вариантом, еще реже встречается аденокарцинома, на которую приходится менее 1 % всех опухолей данной локализации [6,7]. К наиболее распространенным симптомам уротелиального рака верхних мочевыводящих путей относится макро-или микрогематурия, которая встречается в 70-80 % случаев [8]. Опухоль циркулярно поражает стенку мочеточника, суживая ее просвет, что приводит к нарушению оттока мочи из почки и развитию гидронефроза.…”

Section: Introductionunclassified

Organ-Preserving Surgery in Urethral Cancer (a Clinical Case)

Kholopova

Venskel

Коваленко

et al. 2021

Kreativnaâ hirurgiâ i onkologiâ

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Background. Despite low incidence, malignant urethral neoplasms are among the most aggressive tumours. Prevalence of muscle-invasive and metastatic cancer at diagnosis, as well as a high relapse rate compel adherence to the most radical treatment. At the same time, the high incidence of urethral tumours in elderly and senile patients and high postoperative complication rates warrant the development of organ-preserving treatment.Aim. A case description to verify the organ-preserving treatment applicability in urethral cancer.Materials and methods. We report the treatment experience in a senile patient with concomitant chronic kidney disease at the Volgograd Regional Clinical Oncology Dispensary’s Oncourology Unit. Accounting for the age, concomitant pathology and tumour histology factors, a minimally invasive organ-preserving surgical intervention was performed as laparoscopic urethral resection with ureterocystoneostomy.Results and discussion. Renal function was assessed in postoperative period with dynamic nephroscintigraphy and blood creatinine monitoring. Control cysto-, ureteroscopy and contrast-enhanced CT scanning in areas of interest were performed to rule out relapse and progression.Conclusion. No report of disease relapse or progression at follow-up indicates the oncological safety of organ-preserving surgery in this patient category. Th is approach also gains support from immediate and long-term outcomes of the patient’s improved renal function and sustained good quality of life.

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Prevalence and oncologic impact of chronic kidney disease for upper tract urothelial carcinoma in endemic area

Lee,

Wang,

Liu

et al. 2024

Journal of the Formosan Medical Association

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Estimated Glomerular Filtration Rate as a Prognostic Factor in Urothelial Carcinoma of the Upper Urinary Tract: A Systematic Review and Meta-Analysis

Cited by 4 publications

References 45 publications

Oncologic outcomes following radical nephroureterectomy for upper tract urothelial carcinoma: a literature review

Oncologic outcomes following radical nephroureterectomy for upper tract urothelial carcinoma: a literature review

Organ-Preserving Surgery in Urethral Cancer (a Clinical Case)

Prevalence and oncologic impact of chronic kidney disease for upper tract urothelial carcinoma in endemic area

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