Preoperative Prediction of Central Lymph Node Metastasis in Thyroid Papillary Microcarcinoma Using Clinicopathologic and Sonographic Features

Kim, Kyung Eun; Kim, Min Jung; Yoon, Jung Hyun; Han, Kyunghwa; Moon, Hee Jung; Kwak, Jin Young

doi:10.1007/s00268-012-1826-3

Cited by 97 publications

(102 citation statements)

References 70 publications

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“…Few studies have reported the associations between US characteristics and CLNM. In the present study, no significance was identified for these associations, which is consistent with a previous study by Kim et al (24). A number of previous studies have reported that age is not associated with CLNM in patients with PTMC (24,25).…”

Section: Discussionsupporting

confidence: 83%

“…In the present study, no significance was identified for these associations, which is consistent with a previous study by Kim et al (24). A number of previous studies have reported that age is not associated with CLNM in patients with PTMC (24,25). However, Wang et al (26) demonstrated that there is a significant difference between patients <45 years old and ≥45 years old in cN0 PTMC.…”

Section: Discussionsupporting

confidence: 81%

“…The association between tumor multifocality and CLNM remains controversial. In the present study, multifocality was not an independent predictor of CLNM, which is not consistent with previous reports (21,24). Therefore, the TTD, which was defined as the sum of the maximal diameter of each lesion, was calculated.…”

Section: Discussionmentioning

confidence: 43%

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Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China

et al. 2015

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Abstract. Central lymph node metastasis (CLNM) is common in papillary thyroid microcarcinoma (PTMC). The aim of the present study was to investigate the risk factors associated with CLNM in clinical lateral cervical lymph node-negative (cN0) PTMC in Eastern China. A total of 392 patients with confirmed PTMC by histological examination who underwent thyroidectomy and central neck lymph node dissection (CND) between May 2011 and October 2012 at the First Affiliated Hospital of Wenzhou Medical University (Wenzhou, China) were enrolled. The clinicopathological and ultrasonographic data from the patients were analyzed retrospectively. A scoring system was developed on the basis of independent predictive factors for CLNM. Male gender, age <45 years, maximum tumor diameter >5 mm, lower lobe location, multifocal carcinoma with total tumor diameter >10 mm and extracapsular spread were independent predictive factors for CLNM according to logistic regression analysis. The clinicopathological score was statistically significant, with an index point ≥2 indicating CLNM with 86.2% sensitivity and 70.4% specificity. The findings of the present study indicate that CND may be recommended to be routinely performed when the clinicopathological index point ≥2.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 81%

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Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China

et al. 2015

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“…Kim et al (2013) also demonstrated that multifocaltiy is an independent predictive factor for central LNM. In our study, 32.6% of PTMC patients was found multifocality, and 45.2% of them had central LNM, which , in univariate analysis, was significantly higher than unifocal (p=0.002).…”

Section: Discussionmentioning

confidence: 80%

Risk Factors for Nodal Metastasis in cN0 Papillary Thyroid Microcarcinoma

Zhang¹,

Liu²,

Liu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Several studies reported that the tumor recurrence rate increases in multifocal tumors (24,25). In one study, the risk of CLNM is higher in bilateral tumor because of the tendency of large tumor size and more frequent extrathyroidal invasions (26,27). However, according to Zhao et al (28), not only multifocality but both tumor size and multifocality are considered to be related to CLNM.…”

Section: Discussionmentioning

confidence: 95%

Predictive Factors for Central Neck Lymph Node Metastasis in Patients with Papillary Thyroid Microcarcinoma without Suspicious Metastasis by Preoperative Ultrasonography

Jeong

Kim

2017

J Endocr Surg

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Purpose: We aimed to determine the influencing factors for central neck lymph node metastasis (CLNM) in papillary thyroid microcarcinoma (PTMC) without clinical evidence of metastasis on preoperative ultrasonography. Methods: We retrospectively analyzed 625 patients with PTMC who underwent thyroid surgery at Chosun University Hospital from January 2002 to December 2012. A total of 575 patients who had no evidence of lymph node metastasis by preoperative ultrasonography were included in the study. Medical records, including clinical information and pathologic report, were reviewed. Results: Central lymph node metastasis was found in 81 (14.1%) out of 575 patients. Results of univariate analysis indicated that lymph node metastasis occurred frequently in patients with more than 0.5 cm largest tumor size by preoperative sonography and pathologic reports (P=0.048 and P=0.001, respectively) and lymphovascular invasion (LVI) (P<0.001). Multivariate analysis revealed that sex (female vs. male), pathologic tumor size (0.5-1.0 cm vs. <0.5 cm), and LVI (yes vs. no) were significantly associated with lymph node metastasis (odds ratio [OR], 0.498, 95% confidence interval [CI], P=0.047; OR, 2.450, 95% CI, P=0.005; and OR, 24.954, 95% CI, P=0.007, respectively). Conclusion: Male sex, large tumor size (≥0.5 cm), and LVI were the risk factors for CLNM in patients with PTMC without clinical evidence of node metastasis. Prophylactic central neck lymph node dissection (CLND) might be required in these cases of PTMC.

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Preoperative Prediction of Central Lymph Node Metastasis in Thyroid Papillary Microcarcinoma Using Clinicopathologic and Sonographic Features

Cited by 97 publications

References 70 publications

Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China

Prediction of central lymph node metastasis in 392 patients with cervical lymph node-negative papillary thyroid carcinoma in Eastern China

Risk Factors for Nodal Metastasis in cN0 Papillary Thyroid Microcarcinoma

Predictive Factors for Central Neck Lymph Node Metastasis in Patients with Papillary Thyroid Microcarcinoma without Suspicious Metastasis by Preoperative Ultrasonography

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