Predictive Factors for Central Neck Lymph Node Metastasis in Patients with Papillary Thyroid Microcarcinoma without Suspicious Metastasis by Preoperative Ultrasonography

Jeong, Su Yeon; Kim, Yoo Seok; Kim, Kweon Cheon

doi:10.16956/jes.2017.17.3.114

Cited by 2 publications

(1 citation statement)

References 32 publications

(36 reference statements)

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“…Presently, many scholars [15][16][17] believe that microcalcification of lymph nodes has high specificity for thyroid cancer and can be used as the most specific ultrasound indicator for the diagnosis of lymph node metastasis. The results of thyroid nodule ultrasound and neck lymph node ultrasound with microcalcification in the high-and low-risk PTC groups in this study are consistent with those of previous studies, indicating that it can be used as an ultrasound indicator of lymph node metastasis.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic Diagnosis of Thyroid Papillary Carcinoma Metastasis

Duan¹,

Fu²,

Zhou³

et al. 2023

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This study selected the medical record data of patients who underwent ultrasound examination and surgical treatment at Shaw Hospital, affiliated with Zhejiang University Medical College, from January 2018 to June 2020 and screened nine high-risk patients with thyroid papillary carcinoma and eight low-risk patients who met the enrollment criteria. The pathological and ultrasonic imaging data of the thyroid nodules and cervical lymph nodes of the enrolled patients were retrospectively analyzed. Clinicopathological aspects: age, number of lesions, lymph node area, and number of lymph nodes were significant. The younger the age, the higher the risk of cancer metastasis; the more the lymph node metastasis areas, the greater the number of lesions, and the higher the risk of cancer metastasis. An ultrasound image analysis of thyroid nodules showed that the number of microcalcifications and lesions was significantly and positively correlated with the risk of cancer metastasis. Ultrasonic image analysis of cervical lymph nodes showed that the indicators of cystic change, the number of calcifications, number of lymph node fusions, and number of clear lymph node boundaries were significantly and positively correlated with the risk of cancer metastasis. This study is crucial in the clinical diagnosis of thyroid papillary carcinoma metastasis and provides a theoretical basis for surgeons to formulate diagnosis and treatment plans for thyroid carcinoma.

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Section: Discussionmentioning

confidence: 99%

Ultrasonographic Diagnosis of Thyroid Papillary Carcinoma Metastasis

Duan¹,

Fu²,

Zhou³

et al. 2023

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Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis

et al. 2020

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Purpose: To explore the risk factors that may predict the lymph node metastasis potential of these lesions and new prevention strategies in papillary thyroid carcinoma patients. Materials and Methods: In total, 9,369 papillary thyroid carcinoma patients with 37.17% lymph node metastasis were analyzed (Revman 5.3 software) in this study. The PubMed and Embase databases were used for searching works systematically that were published through to January 22, 2020. Results: Several factors were related to the increased risk of lymph node metastasis in patients with papillary thyroid carcinoma: age <45 years (pooled OR = 1.52, 95% CI = 1.14-2.01, p < 0.00001); gender = male (pooled OR = 1.68, 95% CI = 1.51-1.87, p < 0.00001); multifocality (pooled OR = 2.05, 95% CI = 1.45-2.89, p < 0.0001); tumor size ≥1.0 cm (pooled OR = 3.53, 95% CI = 2.62-4.76, p < 0.00001); tumor location at the upper pole 1/3 (pooled OR =1.46, 95% CI = 1.04-2.04, p = 0.03); capsular invasion + (pooled OR = 3.48, 95% CI = 1.69-7.54, p = 0.002); and extrathyroidal extension + (pooled OR = 2.03, 95% CI= 1.78-2.31, p < 0.00001). However, tumor bilaterality (pooled OR = 0.85, 95% CI = 0.54-1.34, p = 0.49) and Hashimoto's thyroditis (pooled OR = 1.08, 95% CI = 0.79-1.49, p = 0.62) showed no correlation with lymph node metastasis in papillary thyroid carcinoma patients. Conclusion: The systematic review and meta-analysis defined several significant risk factors of lymph node metastasis in papillary thyroid cancer patients: age (<45 years), gender (male), multifocality, tumor size (>1 cm), tumor location (1/3 upper), capsular invasion, and extra thyroidal extension. Bilateral tumors and Hashimoto's thyroiditis were unrelated to lymph node metastasis in patients with papillary thyroid cancer.

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Predictive Factors for Central Neck Lymph Node Metastasis in Patients with Papillary Thyroid Microcarcinoma without Suspicious Metastasis by Preoperative Ultrasonography

Cited by 2 publications

References 32 publications

Ultrasonographic Diagnosis of Thyroid Papillary Carcinoma Metastasis

Ultrasonographic Diagnosis of Thyroid Papillary Carcinoma Metastasis

Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis

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