Preoperative positive urine cytology is a risk factor for subsequent development of bladder cancer after nephroureterectomy in patients with upper urinary tract urothelial carcinoma

Kobayashi, Yasuyuki; Sakaguchi, Takashi; Miyaji, Yoshiyuki; Saegusa, Michihisa; Arata, Ryoji; Akebi, Naoki; Takenaka, Tadasu; Manabe, Daisuke; Nasu, Yasutomo; Kumon, Hiromi

doi:10.1007/s00345-011-0731-y

Cited by 41 publications

(42 citation statements)

References 22 publications

(36 reference statements)

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“…Matsui et al [6], Terakawa et al [7], and Hisataki et al [12] also reported that tumor multiplicity was one of the independent risk factors for bladder recurrence. On the other hand, tumor multiplicity was not a risk factor for bladder recurrence in many other studies [8,15,16,19]. It was also not a risk factor for bladder recurrence in our study.…”

Section: Discussionmentioning

confidence: 39%

“…Whereas tumor grade was significantly associated with bladder recurrence in some studies [5,8,13], it showed no such association in many other studies [4,6,7,9,12,15,16,19]. Huang et al [8] suggested that this discrepancy may be due to the differences in the grading criteria, i.e.…”

Section: Discussionmentioning

confidence: 83%

“…On the other hand, Hisataki et al [12] suggested that pathologic stage independently influenced the bladder recurrence, and the bladder recurrence-free rate of lower stage disease tended to be higher than that of higher stage disease. However, tumor stage was not a risk factor for bladder recurrence in many other studies [4,5,8,9,15,16,19]. In this study, we excluded the patients with distant metastasis at diagnosis like many other previous studies because it is probable that many patients with a poor prognosis will die from UUT-UC before developing bladder recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…Kobayashi et al [15] showed that the patients with lower ureter involvement had a significantly higher risk of bladder recurrence than those without lower ureter involvement. However, tumor location was not a risk factor in many other studies [6,7,8,16,19], and the result of our study also supports these findings.…”

Section: Discussionmentioning

confidence: 99%

“…Risk factors such as tumor configuration [8], tumor multiplicity [6,7,9,10], tumor stage [6,7,11,12], tumor grade [5,13], tumor location [5,14,15], patient gender [8,16,17], postoperative adjuvant systemic chemotherapy [16,18], and preoperative voided urine cytology [15,19] have been proposed, but the results remain controversial and no reliable conclusions could be drawn to aid surveillance strategies. Therefore, a clear knowledge of potential predictive factors for bladder recurrence in UUT-UC would allow better prognostic evaluation and aid surveillance strategies.…”

Section: Introductionmentioning

confidence: 99%

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Predictive Factors for Bladder Recurrence after Radical Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Cho¹,

Kim²,

Ahn³

et al. 2013

Urol Int

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Introduction: To identify predictive factors for developing subsequent bladder urothelial carcinoma (UC) in patients undergoing radical nephroureterectomy for the treatment of upper urinary tract UC (UUT-UC). Materials and Methods: We retrospectively reviewed the medical records of 78 patients with clinically localized UUT-UC who had undergone operation at our institution between June 1994 and December 2009. Univariate and multivariate analyses were carried out to determine the predictive factors. Results: Out of a total of 78 patients, 14 (17.9%) developed bladder UC after radical nephroureterectomy at a median interval of 10 months (range: 3-46). Of these 14 patients, 11 (78.6%) experienced bladder recurrence within the first 2 years of follow-up. All 14 patients (100%) had non-muscle-invasive bladder UC and 10 patients (71.4%) had high-grade tumors. The univariate analysis identified preoperative voided urine cytology, tumor configuration, and adjuvant systemic chemotherapy as significant predictive factors for bladder recurrence, whereas the multivariate analysis indicated that only preoperative voided urine cytology was an independent predictive factor. Conclusions: Positive preoperative voided urine cytology is an independent predictor for bladder recurrence after radical nephroureterectomy for UUT-UC. Therefore, closer surveillance of the bladder is necessary, especially in patients with positive preoperative urine cytology.

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Section: Discussionmentioning

confidence: 39%

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Predictive Factors for Bladder Recurrence after Radical Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Cho¹,

Kim²,

Ahn³

et al. 2013

Urol Int

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Management of upper tract urothelial carcinoma

Lucca

Mathiéu

Klatte

et al. 2018

Evidence‐Based Urology

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A review of upper urinary tract cytology performance before and after the implementation of The Paris System

Zhang

Miki

Hang

et al. 2020

Cancer Cytopathology

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Urinary cytology (UC) is one of the primary diagnostic modalities used for the screening and surveillance of urothelial carcinoma. Despite its widespread use, UC has suffered from a lack of standardized or reproducible criteria and wide interobserver variability, particularly of the designation of atypical urothelial cells. The Paris System for Reporting Urinary Cytology (TPS), published in 2016, aimed to provide a standardized approach for evaluating UC by creating diagnostic categories with specific cytomorphologic criteria. Recent studies have primarily investigated the application of TPS on lower urinary tract specimens and have mostly shown that TPS implementation has improved the performance of UC specimens. Only a few studies have reported the impact of TPS on upper urinary tract (UUT) cytology. Additionally, there is uncertainty as to which cytological features are most predictive of high‐grade urothelial carcinoma (HGUC) in the UUT. This review summarizes the literature regarding the utility and performance of UUT cytology and highlights findings before and after the implementation of TPS.

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Preoperative positive urine cytology is a risk factor for subsequent development of bladder cancer after nephroureterectomy in patients with upper urinary tract urothelial carcinoma

Abstract: Risk factor for subsequent development of bladder cancer after NUx was preoperative positive urine cytology.

Cited by 41 publications

References 22 publications

Predictive Factors for Bladder Recurrence after Radical Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Predictive Factors for Bladder Recurrence after Radical Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Management of upper tract urothelial carcinoma

A review of upper urinary tract cytology performance before and after the implementation of The Paris System

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