Preoperative poor coronary collateral circulation can predict the development of atrial fibrillation after coronary artery bypass graft surgery

Güngör, Hasan; Eryılmaz, Ufuk; Akgüllü, Çağdaş; Zencir, Cemil; Kurtoğlu, Tünay; Selvi, Mithat; Onay, Sevil; Zorlu, Ali; Ceyhan, Ceyhun; Onbasili, Alper; Tekten, Tarkan

doi:10.1097/mca.0000000000000025

Cited by 9 publications

(8 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our previous study identified poor coronary collateral circulation preoperatively as a powerful predictor of AF after CABG surgery. Good collateral coronary circulation can affect the occurrence of AF after CABG surgery by reducing atrial and myocardial ischemia, oxidative damage, inflammation, fibrosis, lipid deposition, and dilatation [21] . Therefore, higher platelet volume may cause atrial and myocardial tissue ischemia by changing blood viscosity and increasing inflammation, thus increasing the risk of AF.…”

Section: Discussionmentioning

confidence: 99%

Association of Preoperative Platelet-to-Lymphocyte Ratio with Atrial Fibrillation after Coronary Artery Bypass Graft Surgery

Güngör¹,

Babu

Zencir³

et al. 2016

Med Princ Pract

Self Cite

View full text Add to dashboard Cite

Objective: The aim of this study was to investigate the association between platelet-to-lymphocyte ratio (PLR) and atrial fibrillation (AF) after coronary artery bypass graft (CABG) surgery. Subjects and Methods: A total of 125 patients were retrospectively analyzed. AF was diagnosed using standard clinical criteria, and PLR was calculated as the ratio of the platelets to lymphocytes, obtained from the blood samples that were taken in the fasting state before CABG surgery. The association of different variables with postoperative AF and PLR was calculated using univariate and multivariate analysis. The receiver operating characteristics curve was used to determine the sensitivity and specificity of PLR and the optimal cutoff value for predicting post-CABG AF. Results: Of the 125 patients, 50 with AF (mean age: 67.0 ± 9.5 years, 38 males and 12 females) and 75 patients without AF (mean age: 61.1 ± 9.1 years, 58 males and 17 females) were identified, and the difference in the mean age was statistically significant (p = 0.01). PLR was also significantly higher in those with AF (152.8 ± 82.2) than those without AF (118.2 ± 32.9) (p = 0.012). Univariate analysis showed that age and PLR were associated with AF after CABG surgery (p < 0.001 and p = 0.005, respectively). Using a multivariate logistic regression model with the backward elimination method, age and PLR remained as independent predictors of AF after CABG surgery (p < 0.001 and p = 0.005, respectively). PLR levels >119.3 predicted postoperative AF with 64% sensitivity and 56% specificity (AUC: 0.634, p = 0.012). Conclusion: In this study, age and PLR level were independent predictors of AF after CABG surgery. Patients with an elevated preoperative PLR were at higher risk of AF after CABG surgery.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of Preoperative Platelet-to-Lymphocyte Ratio with Atrial Fibrillation after Coronary Artery Bypass Graft Surgery

Güngör¹,

Babu

Zencir³

et al. 2016

Med Princ Pract

Self Cite

View full text Add to dashboard Cite

show abstract

“…This evaluation was made by two individuals, an interventional cardiologist and a cardiovascular surgeon. Classification was performed as follows [5]: (a) Grade 0: No filling; (b) Grade 1: Inability to visualize the epicardial main vessel structure even though the lateral branches are filled with collaterals; (c) Grade 2: Partial filling of the epicardial main vessel structure with collaterals; and (d) Grade 3: Complete filling of the epicardial main vessel. As a result of this classification, patients with Grade 2 and Grade 3 fillings were included in the study.…”

Section: Evaluation Of Coronary Collateral Circulationmentioning

confidence: 99%

“…The severity of CAD and the quality of circulation in the coronary artery with chronic total occlusion (CTO) are known as indirect indicators of myocardial ischemia [4]. In a study, it was shown that preoperative poor coronary collateral circulation (CCC) increased the risk of PoAF after CABG operations [5]. Other studies have also shown that right coronary artery (RCA) disease or its severity is associated with PoAF [6,7].…”

mentioning

confidence: 99%

“…The incidence of PoAF was significantly higher in patients with poor CCC (37 [49%] vs. 12 [14%], p < 0.001). In the multivariate analysis, poor CCC was found to be an independent predictor of PoAF (OR: 11.500; 95% CI, 3.977-33.253, p < 0.001) [5]. The effect of coronary vascular structure on PoAF was investigated in the study conducted by Polat et al [12] in which 94 CABG patients were included.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Investigation of the effect of coronary collateral circulation quality on postoperative atrial fibrillation after coronary artery bypass graft operations in patients with right coronary artery total occlusion

Abanoz

Yavuz

2022

The European Research Journal

View full text Add to dashboard Cite

Objectives: Postoperative atrial fibrillation (PoAF) may occur in 25-50% of patients after coronary artery bypass graft (CABG) surgery. The severity of coronary artery disease and the quality of coronary collateral circulation (CCC) in the coronary artery with chronic total occlusion (CTO) are known as indirect indicators of myocardial ischemia. In this study, we aimed to investigate the effect of CCC quality on PoAF in patients with right coronary artery (RCA) total occlusion who underwent CABG operation. Methods: Patients who underwent isolated CABG operation between May 15, 2016 and June 15, 2020 and had RCA CTO were included in the study retrospectively. The patients were recorded as Group 1 who developed PoAF in the postoperative period and Group 2 who did not. Results: A total of 99 patients were included in the study. Those who develop PoAF were determined as Group 1 (n = 32, mean age = 66.9 ± 11 years), and those who did not were determined as Group 2 (n = 67, mean age = 54.4 ± 12.8, years). There were no statistically significant differences between the two groups in terms of gender, smoking, diabetes mellitus, hypelipidemia and chronic obstuctive pulmonary disease rates. In multivariate analysis, being over 70 years old (OR: 1.396, 95% CI: 1.080-2.190, p = 0.007), poor CCC (OR: 1.090, 95% CI: 1.045-1.338, p = 0.014) and left atrial diamater (OR: 0.557, 95% CI: 0.471-0.783, p = 0.032) were determined as independent predictors of development of PoAF. Conclusions: In this current study, we demonstrated that low CCC quality increases the risk of POAF in patients with right coronary CTO. CCC quality can be used as an evaluation parameter in identifying groups at risk for PoAF in these special patient groups.

show abstract

“…1) Well-developed coronary collateral arteries have been evidenced previously to limit infarct size, reduce arrhythmia, preserve cardiac function, and eventually improve cardiovascular prognosis. [2][3][4] Coronary collaterals derive embryonic period and develop throughout the whole life, but the interindividual variation of coronary collateral coverage density and function is remarkably wide. 5) The understanding of coronary development and its mechanism is beneficial to provide novel therapy to coronary ischemic disease.…”

mentioning

confidence: 99%

The Relationship Between Circulating Neuregulin-1 and Coronary Collateral Circulation in Patients with Coronary Artery Disease

et al. 2020

View full text Add to dashboard Cite

Coronary collateral circulation (CCC) plays a crucial role in myocardial blood supply, especially for ischemic myocardium. Previous study has shown that neuregulin-1 is a prominent angiogenic factor in diabetic cardiomyopathy, whereas the relationship between neuregulin-1 and CCC has not been investigated. Thus, we aimed to investigate relationship between circulating neuregulin-1 levels and CCC in stable coronary artery disease patients. Coronary artery disease patients with a stenosis of !90% as evidenced by coronary angiography were included in our study. According to the Rentrop-Cohen classification, coronary collateral degree was graded as 1 to 4. Patients with collateral degree grade 0 or 1 were enrolled in poor CCC group, whereas patients with grade 2 or 3 were enrolled in good CCC group. Plasma neuregulin-1 level was significantly increased in good collateral group and positively related to Rentrop grade (P < 0.01). Multivariate regression analysis and ROC (receiver operating characteristic curve) revealed that plasma neuregulin-1 could predict CCC status effectively. Increased plasma neuregulin-1 level was related to better CCC in patients with coronary artery disease. Neuregulin-1 was an independent and reliable predictor for good coronary collateral development and provided a potential therapeutic strategy to reduce myocardial ischemia injury.

show abstract

Preoperative poor coronary collateral circulation can predict the development of atrial fibrillation after coronary artery bypass graft surgery

Abstract: The present study showed that preoperative poor CCC is a powerful predictor of the development of AF after CABG surgery.

Cited by 9 publications

References 18 publications

Association of Preoperative Platelet-to-Lymphocyte Ratio with Atrial Fibrillation after Coronary Artery Bypass Graft Surgery

Association of Preoperative Platelet-to-Lymphocyte Ratio with Atrial Fibrillation after Coronary Artery Bypass Graft Surgery

Investigation of the effect of coronary collateral circulation quality on postoperative atrial fibrillation after coronary artery bypass graft operations in patients with right coronary artery total occlusion

The Relationship Between Circulating Neuregulin-1 and Coronary Collateral Circulation in Patients with Coronary Artery Disease

Contact Info

Product

Resources

About