The Relationship Between Circulating Neuregulin-1 and Coronary Collateral Circulation in Patients with Coronary Artery Disease

Abstract

Coronary collateral circulation (CCC) plays a crucial role in myocardial blood supply, especially for ischemic myocardium. Previous study has shown that neuregulin-1 is a prominent angiogenic factor in diabetic cardiomyopathy, whereas the relationship between neuregulin-1 and CCC has not been investigated. Thus, we aimed to investigate relationship between circulating neuregulin-1 levels and CCC in stable coronary artery disease patients. Coronary artery disease patients with a stenosis of !90% as evidenced by coronary angiography were included in our study. According to the Rentrop-Cohen classification, coronary collateral degree was graded as 1 to 4. Patients with collateral degree grade 0 or 1 were enrolled in poor CCC group, whereas patients with grade 2 or 3 were enrolled in good CCC group. Plasma neuregulin-1 level was significantly increased in good collateral group and positively related to Rentrop grade (P < 0.01). Multivariate regression analysis and ROC (receiver operating characteristic curve) revealed that plasma neuregulin-1 could predict CCC status effectively. Increased plasma neuregulin-1 level was related to better CCC in patients with coronary artery disease. Neuregulin-1 was an independent and reliable predictor for good coronary collateral development and provided a potential therapeutic strategy to reduce myocardial ischemia injury.

Serum levels of neuregulin-1 in patients with coronary artery disease: clinical and pathogenetic aspects

“…Продемонстрировано его непосредственное влияние на кардиомиоциты, эндотелиальные клетки, макрофаги и фибробласты, приводящее к активной пролиферации клеток, антиапоптозу, противовоспалительному и антиоксидантному эффектам, а также регулирующей роли в процессах энергетического метаболизма миокарда [1][2][3][4]. При этом работы по изучению роли NRG-1 у пациентов с ишемической болезнью сердца (ИБС) крайне малочисленны [5,6], а данные, полученные авторами, весьма противоречивы, в связи с чем представляется актуальным изучение концентрации NRG-1 у пациентов с различной выраженностью атеросклеротического поражения коронарных артерий (КА), в т.ч. в рамках их клинико-инструментальных особенностей.…”

“…Примечание: NRG-1 -нейрегулин-1, SYNTAX -Synergy between Percutaneous Coronary Intervention with TAXUS and Cardiac Surgery. 2020), в которых было показано, что концентрации NRG-1 и NRG-4 в плазме крови отрицательно коррелировали с тяжестью ИБС и развитием коллатерального кровотока, а также оказались надежными независимыми предикторами хорошего его развития [6,8]. Rahimzadeh M, et al (2020) продемонстрирована связь NRG-4 с низким риском развития острого коронарного синдрома [9].…”

Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease

“…A recent study demonstrated the positive correlation between circulating NRG-1 and left ventricular ejection fraction [72], supporting the idea that NRG-1 is contributing to compensatory cardiac responses. The levels of both NRG-1 and NRG-4 correlate inversely with the severity of coronary artery disease (CAD) [27,70] and coronary collateral circulation [73]. The potential explanation may include the reduction in the synthesis or secretion of NRG-1 and NRG-4 by endothelial cells [74,75] associated with endothelial dysfunction in CAD [76,77].…”

Relationship between Plasma Neuregulin-1 and MDA Levels with Severity of CAD

“…Oxidative stress and inflammation play a significant role in the atherosclerosis process of CAD. A previous study has shown that neuregulin-1 is a prominent angiogenic factor in diabetic cardiomyopathy, whereas the relationship between neuregulin-1 and MDA plasma level has not been investigated [3]. The malondialdehyde (MDA) was produced during oxidative stress on lipid peroxidation [2].…”