Preoperative platelet to lymphocyte ratio is a valuable prognostic biomarker in patients with colorectal cancer

You, Jie; Zhu, Gui‐Qi; Xie, Linka; Liu, Wen-Yue; Shi, Liang; Wang, Ouchen; Huang, Zong-hai; Braddock, Martin; Guo, Gui-Long; Zheng, Ming‐Hua

doi:10.18632/oncotarget.8334

Cited by 63 publications

(60 citation statements)

References 37 publications

(47 reference statements)

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“…Moreover, a higher PLR level was correlated with adverse postoperative survival in CRC patients 16–18. In this study, we also found that there is an association of high PLR with right-sided colon cancer (RCC), but not left-sided colorectal cancer (LCRC) ( P =0.001).…”

Section: Discussionsupporting

confidence: 51%

Impact of platelet to lymphocyte ratio and metabolic syndrome on the prognosis of colorectal cancer patients

You¹,

Zhang²,

Shen³

et al. 2017

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ObjectiveThe aim of this study was to evaluate the prognostic value of both platelet to lymphocyte ratio (PLR) and metabolic syndrome (MetS) in colorectal cancer (CRC) patients.Patients and methodsWe retrospectively enrolled 1,163 CRC patients. Preoperative values of PLR were stratified into three groups according to cut-off values of 120 and 220. The Kaplan–Meier analysis was used to calculate cumulative survival rate related to PLR and MetS. Cox proportional hazard regression models were used to analyze potential risk factors and the prognosis associated with PLR and MetS in CRC patients.ResultsPLR was significantly higher in the MetS(+) group as compared to MetS(−) group (P=0.039). An elevated PLR was significantly associated with mortality (P=0.014), but not the existence of MetS (P=0.235). In multivariate regression analysis, PLR was an independent risk factor for overall survival (OS) (P=0.046). For the subgroup with a PLR >220, MetS was an independent predictor for both OS and disease-free survival (P=0.039 and P=0.047, respectively) by multivariate analysis adjusting for confounding covariates. In addition, the presence of MetS was associated with a 2-fold increased risk of mortality and tumor recurrences (hazard ratio [HR] =2.0 and HR =1.9, P<0.05, respectively).ConclusionPreoperative PLR was associated with MetS in CRC patients. Testing for the combined presence of PLR and MetS could potentially improve the predictive accuracy of CRC prognosis.

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Section: Discussionsupporting

confidence: 51%

Impact of platelet to lymphocyte ratio and metabolic syndrome on the prognosis of colorectal cancer patients

You¹,

Zhang²,

Shen³

et al. 2017

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“…29 Another study carried out with a similar patient group set the cut-off value for PLR at 157.8 and concluded that higher values were prognostic factors for disease-free survival and overall survival; the same study also reported a significant relationship between increased PLR level and mortality. 30 Although the present study also detected a higher preoperative PLR in the relapsed group compared to the relapse-free, the difference remained under the threshold of significance. Interestingly, the present study detected that PLR fell at the time of relapse, contrary to the literature.…”

Section: Discussioncontrasting

confidence: 70%

The Use of Neutrophil/Lymphocyte Ratio (Nlr), Platelet/Lymphocyte Ratio (Plr), and Mean Platelet Volume (Mpv) As Inflammatory Biomarkers in the Prognosis of Patients with Early-Stage Colorectal Adenocarcinoma

Kazaz¹

2017

UHOD

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Colorectal cancer (CRC) represents the most prevalent cancer of the gastrointestinal system in adults. Despite long-term survival rates achieved by early resection and adjuvant therapies, relapse is a significant problem for those patients. The present study aims to investigate the possibility of using neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV) as biomarkers for postoperative relapse in patients with CRC. We retrospectively analyzed 188 non-metastatic CRC patients followed up and treated at Dokuz Eylül University, Faculty of Medicine Hospital, Medical Oncology Clinic. We recorded demographic, laboratory and histopathological data from patient files and we calculated NLR, PLR and MPV, which were recorded as preoperative, postoperative and relapse values. This study classified patients into two groups: relapsed and relapse-free patients. Twenty-five patients (13.3%) developed a relapse during the follow-up period. The relapsed group had a higher NLR prior to tumor resection compared to the relapse-free patients, whereas PLR and MPV were not high. Despite the absence of any significant change in NLR or MPV after tumor resection, PLR displayed an upwards trend. At the time of relapse, CEA and MPV increased as PLR fell (compared to the postoperative period). The relapse-free group exhibited a significant decrease in CEA and MPV after tumor resection, and other parameters did not change. Comparing the results based on disease stages, stage III patients had significantly higher MPV levels than the stage II. NLR, MPV and PLR may help physicians identify prognosis after tumor resection in patients with CRC.

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“…The inflammation-based prognostic score such as Glasgow prognostic score,19 neutrophil-to-lymphocyte ratio,20 aspartate aminotransferase-to-platelet ratio,21 and platelet-to-lymphocyte ratio22 was proven to be independent prognostic parameters by previous studies. However, there are still some limitations for the use of these prognostic scores in patients with HCC.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of pretreatment albumin/globulin ratio in patients with hepatocellular carcinoma

Deng¹,

Pang²,

Miao³

et al. 2016

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BackgroundPretreatment nutritional and immunological statuses play an indispensable role in predicting the outcome of patients with various types of malignancies. The purpose of this study is to evaluate the predictive value of albumin/globulin ratio (AGR) in overall survival (OS) and recurrence in patients with hepatocellular carcinoma (HCC) following radical hepatic carcinectomy.Patients and methodsThis retrospective study included a total of 172 patients with HCC with complete medical and follow-up information between 2002 and 2012. AGR was calculated according to the following formula: AGR = albumin/globulin. Receiver operating characteristic curve analysis was performed to determine the optimal cutoff value. The associations of AGR with clinicopathological characteristics and prognosis were assessed. Further multivariate analysis using Cox regression model and subgroup analysis was performed to evaluate the predictive value.ResultsReceiver operating characteristic curve determined 37.65, 31.99, and 1.48 as the optimal cutoff values of albumin, globulin, and AGR in terms of 5-year OS or death, respectively. On the basis of the cutoff value of AGR, all the patients were divided, respectively, into low-AGR (n=105) and high-AGR (n=67) groups. AGR was found to be significantly correlated with age, cancer embolus, international normalized ratio, and postoperative outcome (P<0.05). Hepatitis B virus infection (hazard ratio [HR]: 2.125; 95% confidence interval [CI]: 1.285–3.153), tumor node metastasis stage (HR: 1.656; 95% CI: 1.234–2.223), serum albumin (HR: 0.546; 95% CI: 0.347–0.857), and AGR (HR: 0.402; 95% CI: 0.233–0.691) were independent predictors of OS via univariate and multivariate survival analyses. However, alpha-fetoprotein (HR: 1.708; 95% CI: 1.027–2.838), tumor node metastasis stage (HR: 1.464; 95% CI: 1.078–1.989), and AGR (HR: 0.493; 95% CI: 0.293–0.828) functioned as independent risk variables for predicting recurrence. Moreover, AGR showed superior prognostic value for OS and recurrence in the subgroups with normal level of albumin or survival time beyond 6 months.ConclusionPretreatment AGR might serve as an effective biomarker to evaluate the prognosis of patients with a diagnosis of HCC. Based on the results, AGR, characterized with easy accessibility, objectivity, and noninvasiveness, should be included in the routine assessment of HCC.

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Preoperative platelet to lymphocyte ratio is a valuable prognostic biomarker in patients with colorectal cancer

Cited by 63 publications

References 37 publications

Impact of platelet to lymphocyte ratio and metabolic syndrome on the prognosis of colorectal cancer patients

Impact of platelet to lymphocyte ratio and metabolic syndrome on the prognosis of colorectal cancer patients

The Use of Neutrophil/Lymphocyte Ratio (Nlr), Platelet/Lymphocyte Ratio (Plr), and Mean Platelet Volume (Mpv) As Inflammatory Biomarkers in the Prognosis of Patients with Early-Stage Colorectal Adenocarcinoma

Prognostic significance of pretreatment albumin/globulin ratio in patients with hepatocellular carcinoma

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