Preoperative platelet count improves the prognostic prediction of the FIGO staging system for operable cervical cancer patients

Zheng, Ren; Huang, Xiaoxiu; Jin, Chu; Zhuang, Xin-xin; Ye, Lechi; Zheng, Fangfang; Lin, Feng

doi:10.1016/j.cca.2016.11.008

Cited by 13 publications

(14 citation statements)

References 24 publications

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“…No new eligible studies were obtained in the manual searches of the reference lists of the remaining studies. Finally, a total of 19 studies were included in the present study [27–45]. The flow diagram of the study inclusion is presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Zhao et al included 220 early-stage cervical cancer patients, reporting that the presence of thrombocytosis before treatment was associated with an increased risk of recurrence [44]. Zheng et al indicated an improved predictive performance with combined platelet count and FIGO, as well as additional risk stratification for operable cervical cancer patients [45]. One possible reason for this significant association could be interaction effects between thrombocytosis and tumor burden.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic role of pretreatment thrombocytosis on survival in patients with cervical cancer: a systematic review and meta-analysis

et al. 2019

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Background This meta-analysis summarized the prognostic role of an elevated platelet count before treatment on survival outcomes in patients with cervical cancer. Methods The PubMed, Embase, and Cochrane library electronic databases were systematically searched for studies reporting the effect estimates with 95% confidence intervals (CIs) of pretreatment thrombocytosis on survival from the database inceptions to December 2018. The pooled hazard ratios (HRs) with 95% CIs for overall survival (OS), progression-free survival (PFS), and recurrence-free survival (RFS) were calculated using random-effects models. Results Nineteen retrospective studies that recruited 6521 patients with cervical cancer were eligible for this study. The summary results indicated that an elevated platelet count was significantly associated with a poor OS (HR 1.50; 95% CI 1.19–1.88; P = 0.001), PFS (HR 1.33; 95% CI 1.07–1.64; P = 0.010), and RFS (HR 1.66; 95% CI 1.20–2.28; P = 0.002). Sensitivity analysis indicated that the pooled PFS was variable after sequential exclusion of individual studies. The predictive value of pretreatment thrombocytosis on OS differed according to the publication year ( P = 0.039), country ( P = 0.013), and sample size ( P = 0.029), and the role of pretreatment thrombocytosis on PFS could be affected by the study quality ( P = 0.046). Conclusion The findings of this study indicated that an elevated platelet count before treatment was associated with poor OS, PFS, and RFS. These results require further verification in large-scale prospective studies. Electronic supplementary material The online version of this article (10.1186/s12957-019-1676-7) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic role of pretreatment thrombocytosis on survival in patients with cervical cancer: a systematic review and meta-analysis

et al. 2019

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“…In their study, patients were divided into four groups according to the cutoff pre-operative platelet value (PLT = 272 × 10 9 /L), combined with the FIGO stage. They found that patients with advanced FIGO stage (II) and a high PLT level (PLT ≥ 272 × 10 9 /L) had the worst prognosis 21 . Zhao et al's study indicated that patients with high pre-operative levels of PLT and fibrinogen had a poor prognosis in early stage cervical cancer 22 .…”

Section: Discussionmentioning

confidence: 99%

Combined PLT and NE to predict the prognosis of patients with locally advanced cervical cancer

Wang¹,

Chen

Zhou³

et al. 2020

Sci Rep

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cervical cancer is one of the most common tumors in women. neutrophils (nes) and platelets (pLts) are components of cells in circulating blood. NEs are one of the components of white blood cells (WBCs), accounting for the vast majority of WBCs, recognized as one of the indicators of inflammation. PLTs are associated with thrombosis and inflammation. Both of them play an important role in tumor growth and metastasis. According to pre-radiotherapy PLT and NE media levels, we divided the patients into three groups: PLT and NE both high levels group, single high level group and both low group. By using COX regression models and nomogram, a prognostic model for patients was established. Both high levels of pre-radiotherapy PLT and NE group or high levels of post-radiotherapy PLT and NE group were correlated with worst overall survival (oS) compared with the other two groups. pLt and ne were correlated with outcomes of the patients with locally advanced cervical cancer.

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“… 17 Zheng RR and colleagues found that the combination of platelet count and International Federation of Obstetrics and Gynaecology (FIGO) staging improved the predictive performance of FIGO staging and provided additional risk stratification for patients with operable cervical cancer. 18 Väyrynen JP and colleagues found that high platelet counts are associated with systemic inflammation in colorectal cancer (CRC). 19 However, this study was unable to prove a statistically significant correlation between platelet count, aspirin use and tumour infiltrating immune cell density.…”

Section: The Vital Role Of Platelet Count In Tumour Detectionmentioning

confidence: 99%

“…However, this study was unable to prove a statistically significant correlation between platelet count, aspirin use and tumor infiltrating immune cell density. Väyrynen JP et al, 18 Rectal cancer The mortality of rectal cancer patients with high platelet counts before surgery is higher than that of rectal cancer patients with low platelet levels. Research results suggest that preoperative platelet count can be used as an important indicator for predicting the prognosis of rectal cancer, but its prognostic value for colon cancer needs to be further clarified.…”

Section: The Vital Role Of Platelet Count In Tumour Detectionmentioning

confidence: 99%

Platelets: The Emerging Clinical Diagnostics and Therapy Selection of Cancer Liquid Biopsies

Meng¹,

Sun²,

Yang³

et al. 2021

OTT

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Due to the inherent molecular heterogeneity of metastatic tumours and the dynamic evolution ability of tumour genomes, tumour tissues obtained through biopsy and other methods cannot capture all of the features of tumour genomes. A new diagnostic concept called "liquid biopsy" has received widespread attention in recent years. Liquid biopsy has changed the clinical practice of oncology and is widely used to guide targeted drug utilization, monitor disease progression and track drug resistance. The latest research subject in liquid biopsy is platelets. Platelets originate from multifunctional haematopoietic stem cells in the bone marrow haematopoietic system. They are small cells from the cytoplasm of bone marrow megakaryocytes. Their main physiological functions are to participate in the processes of physiological haemostasis and coagulation. Tumour cells transfer biomolecules (such as RNA) to platelets through direct contact and release of exosomes, which changes the platelet precursor RNA. Under the stimulation of tumour cells and the tumour microenvironment, platelet precursor mRNA is spliced into mature RNA and converted into functional protein to respond to external stimuli, forming tumoureducated platelets (TEPs). The detection of TEPs in the peripheral blood of patients is expected to be used in clinical tumour diagnosis. This emerging liquid biopsy method can replace and supplement the current tumour detection methods. Further research on the role of platelets in tumour diagnosis will help provide a novel theoretical basis for clinical tumour diagnosis.

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Preoperative platelet count improves the prognostic prediction of the FIGO staging system for operable cervical cancer patients

Cited by 13 publications

References 24 publications

Prognostic role of pretreatment thrombocytosis on survival in patients with cervical cancer: a systematic review and meta-analysis

Prognostic role of pretreatment thrombocytosis on survival in patients with cervical cancer: a systematic review and meta-analysis

Combined PLT and NE to predict the prognosis of patients with locally advanced cervical cancer

Platelets: The Emerging Clinical Diagnostics and Therapy Selection of Cancer Liquid Biopsies

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