Preoperative Plasma Hyperfibrinogenemia is Predictive of Poor Prognosis in Patients with Nonmetastatic Colon Cancer

Son, Hae-Jung; Park, Ji Won; Chang, Hee Jin; Kim, Dae Yong; Kim, Jae Hak; Kim, Sun Young; Park, Sung Chan; Choi, Hyo Seong; Oh, Jae Hwan

doi:10.1245/s10434-013-2968-8

Cited by 124 publications

(96 citation statements)

References 23 publications

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“…Fibrinogen converted to insoluble fibrin by activated thrombin significantly affects blood clotting, fibrinolysis, inflammatory response, wound healing and neoplasia [18]. Pretherapeutic plasma fibrinogen levels have been associated with the clinical outcome of patients with various cancers, including urothelial, colorectal, ovarian, and lung cancer [19,20,21,22,23,24,25]. …”

Section: Discussionmentioning

confidence: 99%

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Pretherapeutic Plasma Fibrinogen Level is an Independent Survival Predictor in Renal Cell Carcinoma

Sasaki

Onishi²

2015

Oncol Res Treat

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Background: Systematic inflammatory responses such as the elevated C-reactive protein, erythrocyte sedimentation rate and lymphocyte-monocyte ratio have been found to have significant prognostic value in renal cell carcinoma (RCC). The purpose of this study was to identify the impact of pretherapeutic plasma fibrinogen levels on survival for RCC patients. Patients and Methods: We retrospectively reviewed 126 RCC patients who were treated at our institution. The median follow-up period was 30.8 months. 116 patients underwent nephrectomy. Results: The 3-year overall survival rates in patients with non-metastatic or metastatic RCC were 91.9% and 14.3%, respectively (p < 0.001). Pretherapeutic plasma fibrinogen levels in the metastatic group were significantly higher than those in the non-metastatic group (p < 0.001). In the non-metastatic group, multivariate analysis revealed that the pathological T stage (p = 0.008), lactate dehydrogenase (p = 0.007) and fibrinogen (p = 0.036) were independent prognostic factors for survival. Overall survival rates in patients with low fibrinogen levels (< 399 mg/dl) were significantly higher than in those with high fibrinogen levels (≥ 399 mg/dl). Conclusion: Pretherapeutic high plasma fibrinogen levels are associated with disease progression in patients with RCC of all stages. We propose that pretherapeutic plasma fibrinogen levels may become a useful biomarker, and could be helpful for decision making in the management of RCC.

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Section: Discussionmentioning

confidence: 99%

“…Son et al [21] discussed the association between systemic inflammation and cancer progression. It is possible that the high plasma fibrinogen level is secondary to the increased systemic inflammatory response caused by tumor progression.…”

Section: Discussionmentioning

confidence: 99%

Pretherapeutic Plasma Fibrinogen Level is an Independent Survival Predictor in Renal Cell Carcinoma

Sasaki

Onishi²

2015

Oncol Res Treat

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“…Activated thrombin transforms fibrinogen to fibrin in the coagulation cascade; therefore, fibrinogen is important in the regulation of clot formation, wound healing, and the inflammatory response (6). Furthermore, previous studies have demonstrated that elevated fibrinogen activity enhances tumor aggressiveness in several malignancies, including esophageal, stomach and colorectal carcinomas (7)(8)(9). Consequently, hyperfibrinogenemia is associated with tumor progression and a poor prognosis for patients with malignant disease (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Combined fibrinogen concentration and neutrophil-lymphocyte ratio as a prognostic marker of gastric cancer

et al. 2015

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Abstract. Certain patients with early gastric cancer succumb to recurrent disease and cancer-associated complications. The key cause of recurrence is challenging to determine, since clinical blood markers that are able to predict the tumor properties of gastric cancer are limited. The present study investigated the fibrinogen concentration and neutrophil-lymphocyte ratio (NLR) in blood specimens from patients with gastric cancer, and assessed the clinical applicability of combining the fibrinogen concentration with the NLR (CFS-NLR) as a prognostic marker of gastric cancer. The present study consisted of 275 patients with gastric cancer, who were divided into three groups: Those possessing hyperfibrinogenemia (≥305 mg/dl) and a high NLR (≥2.34; CFS-NLR 2 group); those possessing either hyperfibrinogenemia or a high NLR (CFS-NLR 1 group); or those that possessed neither abnormality (CFS-NLR 0 group). The CFS-NLR was significantly associated with the depth of tumor invasion, lymph node metastasis, lymphovascular invasion and tumor stage (P<0.0001). The prognostic differences among the three groups were significant (P= 0.0016). Therefore, the CFS-NLR may be a potentially useful blood marker for predicting tumor progression and the prognosis of patients with gastric cancer.

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“…Of these, especially fibrinrelated products are frequently associated with advanced disease, prognosis and cancerrelated venous thromboembolism (6,(15)(16)(17). Also, it is shown that these factors show dynamic changes during anti-tumor treatment (8,18).…”

Section: Discussionmentioning

confidence: 99%

High Preoperative Fibrinogen Level is Closely Associated with Receipt of Chemotherapy and Advanced Disease in Patients with Colorectal Cancer

Akar¹

2017

Ulutas Med J

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Background: There is still lack of a preoperative simple, reliable and non-invasive blood marker predicting the stage of the disease (luminal or extraluminal) and the need for chemotherapy at the time of diagnosis in patients with colorectal cancer (CRC). The study aimed to investigate any relationship between the preoperative fibrinogen level and CRC disease stage as well as the receipt of chemotherapy before surgery.Method: A total 297 CRC patients undergoing surgical resection for any reason (curative or palliative) enrolled in this study. The serum fibrinogen level was calculated in the preoperative period. The need for chemotherapy was assessed by two different expert oncologists. Comparisons were made between the fibrinogen level with disease stage as well as the chemotherapy. Results: The mean fibrinogen level was 455±128,5 mg/dL with high level in 77,4% of all CRC patients. The level of fibrinogen in both Duke's C and D significantly were higher than Duke's B (p<0,001). High preoperative fibrinogen level had a 27.9-fold increase the risk of receiving chemotherapy (Hazard Ratio:27.9, P<0.0001,; 95% C.I). The majority of CRC patients receiving chemotherapy (94,4%) had both high fibrinogen and CEA levels.Conclusion: High preoperative fibrinogen is closely linked with receipt of chemotherapy and advanced disease in patients with CRC. Notable, this association is more prominent when fibrinogen and CEA are both high.

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Preoperative Plasma Hyperfibrinogenemia is Predictive of Poor Prognosis in Patients with Nonmetastatic Colon Cancer

Abstract: Fibrinogen as one of inflammatory markers may be considered a possible prognostic marker in colon cancer.

Cited by 124 publications

References 23 publications

Pretherapeutic Plasma Fibrinogen Level is an Independent Survival Predictor in Renal Cell Carcinoma

Pretherapeutic Plasma Fibrinogen Level is an Independent Survival Predictor in Renal Cell Carcinoma

Combined fibrinogen concentration and neutrophil-lymphocyte ratio as a prognostic marker of gastric cancer

High Preoperative Fibrinogen Level is Closely Associated with Receipt of Chemotherapy and Advanced Disease in Patients with Colorectal Cancer

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