Preoperative Localization of Parathyroid Carcinoma Using Tc-99m MIBI

Kitapçı, Mehmet; Taştekin, Güngör; Turgut, Mehmet Cenk; Caner, Biray; Kars, Ayse; Barışta, İbrahim; Bekdik, Coskun

doi:10.1097/00003072-199303000-00007

Cited by 48 publications

(9 citation statements)

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“…13 Sestamibi scanning has also been used successfully to localize primary, metastatic, and recurrent parathyroid carcinoma. [14][15][16] In one series of 14 patients with recurrent parathyroid carcinoma, the sensitivity of sestamibi scanning was reported to be 79%. 2 There was no statistically significant difference between sestamibi scanning and other forms of localization.…”

Section: Discussionmentioning

confidence: 99%

Metachronous spread of parathyroid carcinoma to a retropharyngeal lymph node

Rufener

Cohen

2003

Head & Neck

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Section: Discussionmentioning

confidence: 99%

Metachronous spread of parathyroid carcinoma to a retropharyngeal lymph node

Rufener

Cohen

2003

Head & Neck

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“…Currently, it has also been demonstrated that MIBI scanning is able to localize metastatic parathyroid carcinoma [3], as well as the primary lesion [4].…”

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confidence: 99%

Multiple Brown Tumors in Primary Hyperparathyroidism Caused by an Adenoma Mimicking Metastatic Bone Disease with False Positive Results on Computed Tomography and Tc-99m Sestamibi Imaging: MR Findings

et al. 2007

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Abstract. We encountered an unusual case of hyperparathyroidism with both hemosiderin deposits on the ribs and low intensity on T2-weighted magnetic resonance imaging (MRI) caused by a parathyroid adenoma with multiple brown tumors that mimicked metastatic bone tumor due to false positive results on computed tomography (CT) and Tc-99m sestamibi (MIBI) imaging. The patient, a middle-aged woman, had very high serum levels of calcium (14.1 mg/dl), alkaline phosphatase (9,369 IU/l) and intact-PTH (12,400 pg/ml), and a large tumor (2.5 cm in diameter) in the lower portion of the left lobe of the thyroid. Plain X-ray revealed a soft tumor in the left chest wall. On CT scan, there were multiple destructive masses in the ribs, including large intramedullary masses on both 3rd ribs. On MIBI scintigraphy, there was strong late uptake in the lower portion of the left cervical region, both 3rd ribs, and the left 7th, 8th, and 10th ribs. T2-weighted image MRI scans showed that both 3rd ribs had a low intensity with hemosiderin deposits. These findings suggested that the patient had hyperparathyroidism with multiple bone metastases due to carcinoma of the parathyroid gland. However, on pathology, the resected tumor of lower portion of the left lobe of thyroid was diagnosed as a parathyroid adenoma, and the tumors of the left 3rd and 7th ribs, as well as the right 2nd rib, were shown to be brown tumors. After resection, the patient's serum levels of calcium, alkaline phosphatase, and intact-PTH normalized. At 1.5-years follow-up, CT, MIBI, and MRI scans showed no abnormal findings. It is necessary to determine whether MRI can be used to distinguish between brown tumors and metastases caused by carcinoma of the parathyroid gland. THE most common cause of primary hyperparathyroidism is a solitary adenoma, followed by hyperplasia and carcinoma [1]. Conventional techniques for detecting the location of abnormal parathyroid glands are associated with many difficulties and often yield false negative and false positive results. Recently, Tc-99m hexakis methoxyisobutylisonitrile (MIBI) imaging was established as the best and most convenient localization method for detecting adenoma [1], after having been first reported by Coakley et al.

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“…Following the incidental finding of a pulmonary metastasis from thyroid carcinoma during cardiac imaging [14], case reports describing uptake in osteosarcoma [15], breast carcinoma [16], lymphoma [17], bronchogenic carcinoma [181 and parathyroid carcinoma [19], as well as in medullary carcinoma [20] and Huerthle cell carcinoma [21] of the thyroid, have appeared. Accumulation of the agent in human carcinoma cell lines in vitro [11] and in transplantable brain tumours in rats [22] has also been described.…”

Section: Discussionmentioning

confidence: 99%

Technetium-99m methoxyisobutylisonitrile localizes an ectopic ACTH-producing tumour: case report and review of the literature

et al. 1994

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Extensive investigation including whole-body examinations with computed tomography and magnetic resonance imaging did not detect the suspected ectopic ACTH-producing tumour in a patient with advanced Cushing's syndrome and hypokalemic alkalosis. Gamma camera examination with technetium-99m methoxyisobutylisonitrile (MIBI) depicted the tumour, which was localized in the anterior neck and mediastinum. This was later verified by surgery. 99mTc-MIBI is normally used for myocardial scintigraphy. Its accumulation is unspecific and merely reflects metabolic activity. Despite this, the present case shows that examination with this agent can provide important information with regard to tumour localization in a given situation, thereby serving as a complement to other imaging modalities. The current literature on 99mTc-MIBI for tumour diagnosis is reviewed.

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Preoperative Localization of Parathyroid Carcinoma Using Tc-99m MIBI

Cited by 48 publications

References 0 publications

Metachronous spread of parathyroid carcinoma to a retropharyngeal lymph node

Metachronous spread of parathyroid carcinoma to a retropharyngeal lymph node

Multiple Brown Tumors in Primary Hyperparathyroidism Caused by an Adenoma Mimicking Metastatic Bone Disease with False Positive Results on Computed Tomography and Tc-99m Sestamibi Imaging: MR Findings

Technetium-99m methoxyisobutylisonitrile localizes an ectopic ACTH-producing tumour: case report and review of the literature

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