Preoperative Levels of Matrix Metalloproteinase-7 and -9 and Tissue Inhibitor of Matrix Metalloproteinase-1 Relation to Pathologic Parameters in Bladder Carcinoma Patients

Güneş, Mustafa; Kemik, Ahu Serap; Pirinççi, Necip; Geçit, İlhan; Taken, Kerem; Yüksel, Mehmet Bilgehan; Kaba, Mehmet; Eryılmaz, Recep

doi:10.7314/apjcp.2013.14.2.873

Cited by 8 publications

(8 citation statements)

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“…J SAFRANEK et al [28] reported higher expression of MMP7 mRNA and lower expression of TIMP1 mRNA in NSCLC tissue as compared to nontumour lung tissue, offering the first step for further application. Mustafa Gunes et al [29] reported that the preoperative serum levels of MMP7 were significantly higher in patients with bladder cancer with metastatic disease, lymphovascular involvement, and lymph node metastasis than in control groups, but serum TIMP1 levels showed the opposite result. These investigations indicate that TIMP1 may be an antagonist against the proteolytic effect of MMP7.…”

Section: Discussionmentioning

confidence: 99%

Elevated matrix metalloproteinase 7 expression promotes the proliferation, motility and metastasis of tongue squamous cell carcinoma

et al. 2020

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Background: Matrix metalloproteinase 7 (MMP7), as the smallest member of the matrix metalloproteinase family, has been verified to be implicated in cancer progression, especially metastasis. However, its expression pattern and function in tongue cancer is not clear. Methods: The expression of MMP7 in human tongue squamous cell carcinoma (TSCC) specimens compared with their respective paired nontumour tissues by real-time PCR and immunohistochemical staining. The effect of MMP7 on the proliferation, apoptosis, migration, invasion of tongue cancer cells was tested in appropriate ways after MMP7 siRNA knockdown or overexpression. The effect of MMP7 on lymph node metastasis in vivo was analyzed using a high-metastasis orthotopic nude mouse tongue transplanted tumour model. Results: We found markedly elevated expression of MMP7 in human TSCC specimens compared with their respective paired nontumour tissues, and this high expression was correlated with the patients' lymph node metastasis. Furthermore, the results of molecular functional assays confirmed that MMP7 promotes cell proliferation, migration and invasion of TSCC cells. Knockdown of MMP7 inhibited lymph nodes metastasis in vivo. Conclusions: MMP7 plays an oncogenic role in carcinogenesis and metastasis of tongue cancer, and may serve as a potential therapeutic target for tongue cancer.

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Section: Discussionmentioning

confidence: 99%

Elevated matrix metalloproteinase 7 expression promotes the proliferation, motility and metastasis of tongue squamous cell carcinoma

et al. 2020

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“…Additional studies were excluded as they were not case-control or cohort studies (n=19), were irrelevant to the present study (n=4) or possessed incomplete data (n=1). Overall, 23 case-control studies (15,(18)(19)(20)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47), published between 1998 and 2014, were selected for meta-analysis, and consisted of 1,040 bladder cancer patients and 244 healthy control individuals. Among the 23 studies, the study subjects in 3 studies were African, 14 studies enrolled Asian subjects and 6 studies enrolled Caucasian subjects.…”

Section: Resultsmentioning

confidence: 99%

“…The proteolytic activity of MMP-9 against collagen type IV not only promotes invasion and metastasis, but also releases matrix-bound growth factors and other signaling molecules to promote growth signaling, angiogenesis and an inflammatory response (9,17). Previous studies have revealed that MMP-9 is involved in the pathogenesis of bladder cancer (3,9,15,18); however, alternative studies fail to establish an association between MMP-9 expression and bladder cancer, leading to the conclusion that MMP-9 may not be an effective marker for bladder cancer detection (19,20). Due to the conflicting results of previous studies, the present study investigated the association between MMP-9 and the pathogenesis of bladder cancer using a retrospective meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

Elevated matrix metalloproteinase-9 expression may contribute to the pathogenesis of bladder cancer

Zeng

Cen²,

Kang³

2016

Oncology Letters

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Abstract. The present study investigated the potential association between matrix metalloproteinase-9 (MMP-9) expression and the pathogenesis of bladder cancer. The present study reviewed previous studies published in Chinese and English using predefined selection criteria, which identified high-quality studies concerning MMP-9 and bladder cancer. Statistical analyses of the data were conducted using Comprehensive Meta-Analysis software version 2.0. In total, 23 case-control studies were selected, which consisted of 1,040 bladder cancer patients and 244 healthy controls. The expression rates and protein levels of MMP-9 were significantly increased in bladder cancer patients compared with the healthy controls, which was demonstrated using immunohistochemistry (IHC) and enzyme-linked immunosorbent assay-based methods. Furthermore, the expression rate of MMP-9 in histological G1/G2 grade bladder cancer tumors was significantly decreased compared with G3 tumors. Subgroup analysis based on ethnicity demonstrated that the rate of MMP-9 protein expression between bladder cancer patients and healthy controls was significantly different in African, Asian and Caucasian patients, which was identified using IHC. The MMP-9 protein levels in bladder cancer patients and healthy controls were significantly different between Asian and Caucasian patients, but not African patients. The differences between MMP-9 expression in ethnic groups were also evident in the expression rate of MMP-9 identified in histological G1/G2 grade tumors in Asian and Caucasian patients compared with G3 grade tumors, which was not evident in African patients. In conclusion, the present meta-analysis results markedly indicate that MMP-9 expression is associated with clinicopathological features of bladder cancer, suggesting that MMP-9 may be a useful biomarker in the diagnosis and clinical management of bladder cancer, and may be a valuable therapeutic target. IntroductionWorldwide, bladder cancer is the 7th most common cancer in men and the 17th most common cancer in women (1). Notably, in the developed world, bladder cancer ranks as the 4th and 9th most common cancer in men and women, respectively (2). An estimated 375,000 bladder cancer cases are reported each year around the world, with 68,810 novel cases and ~14,100 mortalities reported in the United States in 2013 (3). Transitional cell carcinoma is the most frequently occurring type of bladder cancer. Other bladder cancer types consist of adenocarcinoma, squamous cell carcinoma and small cell bladder cancer (4,5). Notably, the incidence of bladder cancer increases with age, particularly in men (6). Bladder cancer arises as a result of multistep alterations, among which metastasis is crucial (7). Epidemiological studies have demonstrated that several environmental factors may contribute to bladder cancer risk, including smoking, chronic inflammation, radiation exposure, anticancer drugs and aromatic amines, which are contained in dyes (6,8). The treatment of bladder cancer is based on multiple para...

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“…Matrix metalloproteinases (MMPs) has complex roles including degradation of extracellular matrix, release of proangiogenic substances such as VEGF play a role in facilitating tumor angiogenesis. (11,12) Matrix metalloproteinase-9 (MMP-9) is the type of MMP that is involves in the process of degradation of basement membrane and the formation of new blood vessels are characteristic of the progression in bladder carcinoma. (12) Degradation of basement membrane is the key of tumor invasion which is supported by angiogenesis to support the oxygen and nutrient needs.…”

Section: Introductionmentioning

confidence: 99%

The Role of MMP-9 and VEGF in the Invasion State of Bladder Urothelial Carcinoma

2021

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BACKGROUND: Bladder cancer is the tenth-most common cancer in worldwide and the majority are urothelial carcinomas. The depth of invasion plays important role in the prognostic and therapeutic factor in urothelial carcinomas. The expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) may associated with the progression of bladder carcinoma, such as depth of invasion. In this study, the correlation between these two markers in urothelial bladder carcinoma invasion will be analyzed.METHODS: An analytical observational research with cross-sectional were conducted on 54 formalin fixed paraffin-embedded tissue from radical cystectomy (RC) which were diagnosed as bladder urothelial carcinoma at the Anatomical Pathology Laboratory of Dr. Soetomo Academic Hospital, Surabaya and divided based on the T stage were immunostained using VEGF and MMP-9 monoclonal antibodies. The difference of VEGF and MMP-9 expression in T stage of bladder urothelial carcinoma were analyzed using Kruskal-Wallis and Anova test, the correlation between VEGF and MMP-9 expression in various T stage of bladder urothelial carcinoma were analyzed using Spearman test. RESULTS: This study showed no significant difference of VEGF expression among T stage of bladder urothelial carcinoma (p>0.05) but there was significant difference of MMP-9 expression in T stage of bladder urothelial carcinoma (p=0.043). There was a correlation between VEGF and MMP-9 in various T stage of bladder urothelial carcinoma (rs= 0.50, p=0.001).CONCLUSION: The significant correlation of VEGF and MMP-9 expression in bladder urothelial carcinoma may prove the synergistically role of both proteins in tumor invasion by MMP-9 degradation extracellular matrix.KEYWORDS: urothelial carcinoma, VEGF, MMP-9, T stage

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Preoperative Levels of Matrix Metalloproteinase-7 and -9 and Tissue Inhibitor of Matrix Metalloproteinase-1 Relation to Pathologic Parameters in Bladder Carcinoma Patients

Cited by 8 publications

References 27 publications

Elevated matrix metalloproteinase 7 expression promotes the proliferation, motility and metastasis of tongue squamous cell carcinoma

Elevated matrix metalloproteinase 7 expression promotes the proliferation, motility and metastasis of tongue squamous cell carcinoma

Elevated matrix metalloproteinase-9 expression may contribute to the pathogenesis of bladder cancer

The Role of MMP-9 and VEGF in the Invasion State of Bladder Urothelial Carcinoma

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