Preoperative intravenous midazolam: benefits beyond anxiolysis

Bauer, Kevin P.; Dom, Patrick M.; Ramírez, Alejandra; O’Flaherty, Jennifer E.

doi:10.1016/j.jclinane.2003.07.003

Cited by 101 publications

(84 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…No single drug includes all these features, but BZDs are the most commonly used premedication agents in both adults and children because of their anxiolytic, sedative, and amnesic properties (Kain et al, 1997). They also seem to reduce postoperative nausea and vomiting (Bauer et al, 2004).…”

Section: A Premedicationmentioning

confidence: 99%

“…Most patients do not want prolonged amnesia; i.e., they want to be able to recall events both before and after the procedure (Korttila et al, 1981). Appropriate use of preoperative medication, however, improves patient satisfaction (van Vlymen et al, 1999;Bauer et al, 2004). Most orally administered drugs should be given 60 to 90 min before the patient's arrival in the operating theater to exert their full effects.…”

Section: A Premedicationmentioning

confidence: 99%

See 1 more Smart Citation

Enhancement of GABAergic Activity: Neuropharmacological Effects of Benzodiazepines and Therapeutic Use in Anesthesiology

et al. 2011

View full text Add to dashboard Cite

Section: A Premedicationmentioning

confidence: 99%

Section: A Premedicationmentioning

confidence: 99%

Enhancement of GABAergic Activity: Neuropharmacological Effects of Benzodiazepines and Therapeutic Use in Anesthesiology

et al. 2011

View full text Add to dashboard Cite

“…Furthermore, in addition to its anxiolytic effect, intravenous preadministration of midazolam has been reported to reduce postoperative nausea and vomiting and increase patient satisfaction. 7 Thus, these secondary effects can also be advantageous in improving the patient's perioperative experience. Pretreatment with midazolam may also be useful to erase the memory of propofol injection pain.…”

mentioning

confidence: 99%

Effective Dosage of Midazolam to Erase the Memory of Vascular Pain During Propofol Administration

Sato

Inoue

Hanamoto

et al. 2016

Anesthesia Progress

View full text Add to dashboard Cite

Intravenous sedation with propofol is often administered to anxious patients in dental practice. Pain on injection of propofol is a common adverse effect. This study aimed to determine the age-adjusted doses of midazolam required to erase memory of vascular pain of propofol administration and assess whether the Ramsay Sedation Scale (RSS) after the pretreatment of midazolam was useful to predict amnesia of the vascular pain of propofol administration. A total of 246 patients with dental phobia requiring dental treatment under intravenous sedation were included. Patients were classified according to their age: 30s, 40s, 50s, and 60s. Three minutes after administration of a predetermined dose of midazolam, propofol was infused continuously. After completion of the dental procedure, patients were interviewed about the memory of any pain or discomfort in the injection site or forearm. The dosage of midazolam was determined using the Dixon up-down method. The first patient was administered 0.03 mg/kg, and if memory of vascular pain remained, the dosage was increased by 0.01 mg/kg for the next patient, and then if the memory was erased, the dosage was decreased by 0.01 mg/kg. The effective dosage of midazolam in 95% of each age group for erasing the memory of propofol vascular pain (ED 95 ) was determined using logistic analysis. The accuracy of RSS to predict the amnesia of injection pain was assessed by receiver operating characteristic (ROC) analysis. The ED 95 of midazolam to erase the memory of propofol vascular pain was 0.061 mg/kg in patients in their 30s, 0.049 mg/kg in patients in their 40s, 0.033 mg/kg in patients in their 50s, and 0.033 mg/kg in patients in their 60s. The area under the ROC curve was 0.31. The ED 95 of midazolam required to erase the memory of propofol vascular pain demonstrated a downward trend with age. On the other hand, it was impossible to predict the amnesia of propofol vascular pain using the RSS.

show abstract

“…[16,17] Despite animal studies suggesting the possibility of increased nociception with the use of midazolam, [18] the bulk of clinical studies have either reported better pain control, [16,19,20] or no significant effect. [21][22][23] This study aimed to compare M/M combination with MS in pain control of patients suffering from isolated traumatic fracture of extremities.…”

Section: Introductionmentioning

confidence: 99%

Comparison of morphine–midazolam versus morphine injection for pain relief in patients with limb fractures - a clinical trial

Majidi

Dinpanah

Ashoori

et al. 2015

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

show abstract

Preoperative intravenous midazolam: benefits beyond anxiolysis

Cited by 101 publications

References 26 publications

Enhancement of GABAergic Activity: Neuropharmacological Effects of Benzodiazepines and Therapeutic Use in Anesthesiology

Enhancement of GABAergic Activity: Neuropharmacological Effects of Benzodiazepines and Therapeutic Use in Anesthesiology

Effective Dosage of Midazolam to Erase the Memory of Vascular Pain During Propofol Administration

Comparison of morphine–midazolam versus morphine injection for pain relief in patients with limb fractures - a clinical trial

Contact Info

Product

Resources

About