Comparison of morphine–midazolam versus morphine injection for pain relief in patients with limb fractures - a clinical trial

Majidi, Alireza; Dinpanah, Hossein; Ashoori, Sahar; Motamed, Hassan; Tabatabaey, Ali

doi:10.5505/tjtes.2015.64494

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“…The results of this assessment showed that there is no significant difference between the two groups. So findings of that research show that morphine does not change the pain relief effect of morphine in combination with midazolam (26). Additionally, the experimental studies reveal conflict data about the combinative effect of midazolam and opioid (27)(28)(29).…”

Section: Discussionmentioning

confidence: 88%

Is the Modulation Effect of Midazolam on Morphine Induced Antinociception Time Dependent?

Arslan

Turan

2019

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi

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Aim:The goal of this study was to investigate the effects of morphine, midazolam and midazolammorphine on nociception. Benzodiazepines are known to influence opioid analgesia, and variations can be expected in the interaction between benzodiazepines and opioids at different times of the day. Method:The effects of midazolam, morphine, and midazolam-morphine combination on nociception were evaluated with tail flick test in mice, with together the time-dependent changes. Midazolam has not any antinociceptive effect and it inhibited in a fashion dose-dependent the antinociceptive effect of morphine.

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