Preoperative feeding preserves heart function and decreases oxidative injury in rats

Hoorn, Danny E. C. van; Boelens, Petra G.; Middelaar-Voskuilen, Mariska C. van; Nijveldt, Robert J.; Prins, Hubert A.; Bouritius, Hetty; Hofman, Zandrie; M’Rabet, Laura; Leeuwen, Paul A. M. van; Norren, Klaske van

doi:10.1016/j.nut.2004.12.005

Cited by 18 publications

(24 citation statements)

References 30 publications

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“…Thirteen-hour fasting before intestinal I/R results in more serious intestinal I/R injury than that in the case of 2-h fasting before intestinal I/R. 7) In recent years, nutritional manipulation via the enteral route has been demonstrated to modulate dysfunctional inflammatory responses by preserving gut barrier function and immunity. 8,9) It has been shown that enteral feeding before ischemic insults is beneficial for reducing organ injury and improving survival after intestinal I/R.…”

mentioning

confidence: 99%

Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine

Sato

Itagaki

Oikawa

et al. 2011

Biological & Pharmaceutical Bulletin

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Ischemia-reperfusion (I/R) injury of the intestine is an important factor associated with high rates of morbidity and mortality. Intestinal I/R is a common clinical problem in the settings of severe burns, circulatory shock and strangulation ileus. Intestinal I/R damages remote organs and promotes multi-organ failure. It has been shown that enteral feeding before ischemic insults is beneficial for reducing organ injury and improving survival after intestinal I/R. In that study, the authors used a standard complex enteral diet and they suggested that it is important to find new nutrient formulas. Since reactive oxygen species are responsible for intestinal I/R injury, we focused on a dietary polyphenol, the soy isoflavone genistein. Genistein has a wide spectrum of biochemical and pharmacological activities. However, the possibility of a protective effect of genistein as enteral nutrition on I/R injury has not been investigated. We therefore investigated the protective effect of genistein on oxidative injury using intestinal I/R model rats. We found that genistein, which has combined antioxidant activity from radical scavenging, xanthine oxidase inhibition and chain-breaking effects, exhibits a protective effect on intestinal I/R injury. The results suggest that genistein, a soy isoflavone, has the possibility as a new nutrient formula of enteral feeding.

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mentioning

confidence: 99%

Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine

Sato

Itagaki

Oikawa

et al. 2011

Biological & Pharmaceutical Bulletin

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“…It has been reported that feeding condition has an eŠect on intestinal I/R injury. Thirteen-hour fasting before intestinal I/R resulted in more serious intestinal I/R injury, 9) and presurgical administration of carbohydrates reduced intestinal I/R injury. 10) However, theseˆndings were obtained at an early time (1-3 h) during reperfusion.…”

Section: Introductionmentioning

confidence: 95%

“…9,10) The intestinal I/R injury of 16-h fasted I/ R rats was more severe than that of feeding I/R rats Table 1). However, the severities of in‰ammation and lipid peroxidation had almost no eŠect on the severity of intestinal I/R.…”

mentioning

confidence: 99%

Alteration of P-gp Expression after Intestinal Ischemia-reperfusion Following 16-h Fasting in Rats

et al. 2011

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Alteration of P-glycoprotein (P-gp) expression in‰uences the pharmacokinetics of P-gp substrates after intestinal ischemia-reperfusion (I/R). Fasting before intestinal I/R aŠects intestinal I/R injury. However, the eŠect of fasting on the alteration of P-gp expression after intestinal I/R has not been clariˆed. We previously reported that P-gp expression was altered after intestinal I/R following feeding. In the present study, we investigated the expression of P-gp after intestinal I/R following 16-h fasting. The mdr1a levels were decreased at 6 h in the jejunum, at 1 h in the ileum, at 6 and 24 h in the liver and at 6 h in the kidney. The mdr1b levels were decreased at 6 h in the ileum and at 1 and 6 h in the kidney. The mdr1b level in the liver was increased at 1 and 6 h. The expression of P-gp was decreased at 6 h in the jejunum, at 1, 6 and 24 h in the ileum, and at 6 h in the kidney. These alterations were diŠerent to those after intestinal I/R following feeding. In particular, the decrease in P-gp expression in the 16-h fasting I/R rats occurred at an early time during reperfusion compared with that in the feeding I/R rats. In conclusion, feeding condition aŠects the alteration of P-gp expression after intestinal I/R. Therefore, it is important to understand the patient's feeding condition for safe drug therapy.

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“…CHO loading preserves the energy status of the liver and most importantly reduces insulin resistance (107) . Also, it improves intestinal integrity and reduces bacterial translocation (108) .…”

Section: Pre-operative Carbohydrate Loadingmentioning

confidence: 99%

Novel nutritional substrates in surgery

et al. 2013

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Pharmaco-nutrients have beneficial effects on protective and immunological mechanisms in patients undergoing surgery, which are important for recovery after injury and in combating infectious agents. The aim of this review article was to outline the potential of the administration of nutritional substrates to surgical patients and the underlying mechanisms that make them particularly important in peri-operative care. Surgery causes a stress response, which has catabolic effects on the body's substrate stores. The amino acid glutamine is a stimulating agent for immune cells. It activates protective mechanisms through its role as a precursor for antioxidants and it improves the barrier function of the gut. Arginine also enhances the function of the immune system, since it is the substrate for T-lymphocytes. Furthermore, n-3 PUFA stabilise surgery-induced hyper-inflammation. Taurine is another substrate that may counteract the negative effects of surgical injury on acid–base balance and osmotic balance. These pharmaco-nutrients rapidly become deficient under the influence of surgical stress. Supplementation of these nutrients in surgical patients may restore their protective and immune-enhancing actions and improve clinical outcome. Moreover, pre-operative fasting is still common practice in the Western world, although fasting has a negative effect on the patient's condition and the recovery after surgery. This may be counteracted by a simple intervention such as administering a carbohydrate-rich supplement just before surgery. In conclusion, there are various nutritional substrates that may be of great value in improving the condition of the surgical patient, which may be beneficial for post-operative recovery.

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Preoperative feeding preserves heart function and decreases oxidative injury in rats

Cited by 18 publications

References 30 publications

Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine

Protective Effect of Soy Isoflavone Genistein on Ischemia-Reperfusion in the Rat Small Intestine

Alteration of P-gp Expression after Intestinal Ischemia-reperfusion Following 16-h Fasting in Rats

Novel nutritional substrates in surgery

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