Preoperative extended field radiation with I-125 seed implant in prostatic cancer: a preliminary report of a randomized study

Charyulu, Komanduri; Block, Norman L.; Sudarsanam, Anam

doi:10.1016/0360-3016(79)90945-3

Cited by 10 publications

(4 citation statements)

References 14 publications

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“…125 I brachytherapy was introduced into radiation therapy in 1965 [12,13]. Brachytherapy is the placement of radioactive sources in close proximity to any tumor.…”

Section: Discussionmentioning

confidence: 99%

Percutaneous vertebroplasty combined with interstitial implantation of 125I seeds in banna mini-pigs

Yang

Zhang

et al. 2013

World J Surg Onc

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BackgroundAlthough brachytherapy is one of the most effective ways to treat metastatic spinal tumor with little damage to surrounding healthy tissue, it may cause radiation myelopathy if an overdose occurs. Establishing a valuable animal model can help to find a method to overcome its complications. In the current study, we set up a banna mini-pig model to mimic percutaneous vertebroplasty with 125I seed implantation.MethodsPercutaneous vertebroplasty (PVP) combined with interstitial implantation of 125I seeds, 125I seeds were transplanted into the vertebral body at the T13 level of the spine in banna mini-pigs. After raising them for up to eight months, the spinal cord and vertebral body were collected for pathological analysis.ResultsA potential animal model had been successfully established, no case of radiation myelopathy was found in any of the treated banna pigs, and no significant cellular impairment was noted by pathological analysis.ConclusionsIt proves that PVP with 125I brachytherapy is an effective method to treat metastasis spinal tumor, and that the banna mini-pig can be a suitable model to investigate the mechanism of brachytherapy complications.

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“…125 I brachytherapy was introduced into radiation therapy in 1965 [12,13]. Brachytherapy is the placement of radioactive sources in close proximity to any tumor.…”

Section: Discussionmentioning

confidence: 99%

Percutaneous vertebroplasty combined with interstitial implantation of 125I seeds in banna mini-pigs

Yang

Zhang

et al. 2013

World J Surg Onc

View full text Add to dashboard Cite

show abstract

“…125 I brachytherapy was introduced into radiation therapy since 1965[12,13]. Brachytherapy is the placement of radioactive sources in close proximity to any tumor.…”

Section: Discussionmentioning

confidence: 99%

Pathological impairments induced by interstitial implantation of 125I Seeds in spinal canal of banna mini-pigs

Yang

et al. 2012

World J Surg Onc

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BackgroundUse a banna mini-pig to set up 125I implantation model, and investigate the consequence of radiation-related impairments.MethodsIn present study, 125I seeds were implanted into spinal canal of T13 level of spine in banna mini-pigs. After operation, the pigs were raised up to 8 months, behavior changes were recorded within this period. After 8 months, spinal cords were collected for pathological analysis.ResultsIn this study, a 125I brachytherapy animal model had been successfully established, in the model group, the banna pigs' Tarlov scale decreased from 5 to 2.57 ± 0.36, significant cellular impairments were noted by pathological analysis.ConclusionsWithout any protection and operation improvement, 125I implantation can cause serious histological impairments and moving difficulty for banna mini-pigs; this present research provides an alternative tool to study spinal 125I brachytherapy.

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“…traced back to 1979 when clinical practitioners treated prostate cancer patients with 125 I implantation (10). This method has been widely applied in prostate, brain (11) and lung cancer treatment (12), and has been proven to be effective for the inhibition of cancer progression.…”

Section: A B C Dmentioning

confidence: 99%

Changes in cell cycle, apoptosis and necrosis following the establishment of a 125I brachytherapy model in the spinal cord in Banna mini-pigs

et al. 2011

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Abstract. Brachytherapy is regarded as the most effective method in the treatment of metastatic spinal tumors since little damage is caused to surrounding healthy tissue. However, this method may cause radiation myelopathy if an overdose occurs. In the present study, we established a Banna mini-pig 125 I spinal cord implantation model to provide a tool for the study of how to reduce these types of side effects. Cell cycle alteration, apoptosis and necrosis of spinal cord neurons in the presence of various doses and durations of 125 I brachytherapy were also investigated. The pigs were randomly divided into four groups, A, B, C and D. In group A, four 125 I seeds (total radioactivity, 4.0 mCi) were implanted into the dura mater of the spinal canal at the level of T13. In groups B and C, eight 125 I sources (total radioactivity, 8.0 mCi) were inserted at the same location. Groups A and C were raised for up to 8 months and group B for only 2 months. Neurons from the swine spinal cord at the T13 level were collected and cell cycle analysis was performed. Apoptosis and necrosis were tested by a terminal deoxynucleotidyl transferase dUTP nick endlabeling (TUNEL) assay. The Banna mini-pig brachytherapy model was successfully established. Radiation myelopathy was closely associated with radiation dose and duration, more neurons were blocked in the G2 and S phases as dose and time increased, and an increase in apoptosis and necrosis was detected. Ratios of apoptosis and necrosis were reduced as lower doses and shorter durations of radiation were applied. Our results demonstrate that the Banna mini-pig is an ideal animal to study 125 I brachytherapy. Low-dose and short-term brachytherapy may effectively decrease apoptosis and necrosis in spinal cord cells in Banna mini-pigs.

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Preoperative extended field radiation with I-125 seed implant in prostatic cancer: a preliminary report of a randomized study

Cited by 10 publications

References 14 publications

Percutaneous vertebroplasty combined with interstitial implantation of 125I seeds in banna mini-pigs

Percutaneous vertebroplasty combined with interstitial implantation of 125I seeds in banna mini-pigs

Pathological impairments induced by interstitial implantation of 125I Seeds in spinal canal of banna mini-pigs

Changes in cell cycle, apoptosis and necrosis following the establishment of a 125I brachytherapy model in the spinal cord in Banna mini-pigs

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