Preoperative estimation of remnant hepatic function using fusion images obtained by 99mTc-labelled galactosyl-human serum albumin liver scintigraphy and computed tomography

Abstract

A combination of receptor concentration and the amount of hepatic receptor in the future liver remnant as detected on fusion images is useful in evaluating the risk of postoperative liver failure.

HCC: current surgical treatment concepts

“…One major drawback is the inability of these methods to precisely stratify the necessary FLR according to the degree of functional impairment in cirrhotic patients. Appropriate functional evaluation of the FLR can yet be achieved using varied techniques such as combined ICG-R15 and volumetry [57], 99Tc-labelled galactosyl human serum albumin liver scintigraphy and computed tomography [58] or Tc-labelled mebrofenin hepatobiliary scintigraphy with single photon emission computed tomography. They offer the advantage of coupling a metabolic test with morphological assessment of the FLR and have shown excellent results.…”

Alterations in hepatic lobar function in regenerating rat liver

“…Some studies postulate that liver regeneration is promoted at the expense of liver function, resulting in prolonged and less functional regeneration compared with the rapid increase in FLR volume [4e6]. Other works, based on nuclear imaging techniques (i.e., hepatobiliary scintigraphy [7] or hepatocyte mass scintigraphy [8,9]), indicate that increase in FLR function is more pronounced than implied by the degree of morphologic regeneration. This hypothesis, however, has not yet been confirmed by other widely accepted quantitative liver function tests.…”

The Role of Organic Anion Transporters in Diagnosing Liver Diseases by Magnetic Resonance Imaging

“…However, with the recent advances in surgical techniques, which allow various types of partial hepatectomies as well as resection of injured segments once hypertrophy of remnant segments is high enough to avoid postoperative acute liver failure, it is no longer sufficient to determine the global liver function and volume; it is necessary to assess the volume as well as the functional capacity of each segment of the liver (Schnitzbauer et al, 2012). Up to now, liver SPECT was widely used to assess this regional liver function (Bennink et al, 2004;Yumoto et al, 2010;Bennink et al, 2012). However, the spatial resolution of images is poor.…”