HCC: current surgical treatment concepts

Cauchy, François; Fuks, David; Belghiti, Jacques

doi:10.1007/s00423-012-0911-2

Cited by 59 publications

(38 citation statements)

References 145 publications

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“…For long time, there had been a consensus that a diagnosis of Child-Pugh class C was a contraindication for [31]. Abdel-Atty et al [32] reported safe LLR in three Child-Pugh class C patients.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic liver resection for hepatocellular carcinoma in cirrhotic patients: 10-year single-center experience

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Laparoscopic liver resection for hepatocellular carcinoma in cirrhotic patients: 10-year single-center experience

et al. 2015

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“…Although liver transplantation is also a treatment option, the shortage of donated organs limits its wider application in clinical practice. Other therapeutic measures, including chemotherapy and transcatheter arterial chemoembolization have been used to treat HCC, but have failed to produce an observable effect (5). Therefore, increased knowledge concerning the underlying mechanisms of the tumorigenesis and/or progression of HCC is urgently required to identify an effective method for managing patients with HCC.…”

Section: Introductionmentioning

confidence: 99%

Dysregulation of GTPase IMAP family members in hepatocellular cancer

Huang¹,

Zhang²,

Gao³

et al. 2016

Molecular Medicine Reports

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Hepatocellular carcinoma (HCC) is one of the most life-threatening diseases in the world. Members of the GTPase of the immunity-associated protein (GIMAP) family are important in regulating apoptosis in cancer cells. However, the basic mechanism of GIMAP in HCC remains to be fully elucidated. The present study was performed to investigate the dysregulation of GIMAP family members in HCC. The techniques of polymerase chain reaction analysis, immunohistochemistry and ELISA were used to analyze the expression of GIMAP5 and GIMAP6 in HCC tissues, in matched noncancerous tissue samples, and in blood samples obtained from patients with HCC and healthy subjects. It was found that the mRNA expression levels of GIMAP5 and GIMAP6 were significantly downregulated in the HCC tumor samples, compared with the levels of expression in the matched non-tumor tissue samples. Similarly, the mRNA expression levels of GIMAP5 and GIMAP6 were also significantly downregulated in the blood samples from patients with HCC, compared with the expression levels in the blood from healthy subjects. At the protein level, it was found that the GIMAP5 and GIMAP6 proteins were expressed at lower levels in the tumor tissue samples, compared with the matched normal tissue samples, and their expression levels were also lower in the blood samples from patients with HCC, compared with the blood samples from the healthy subjects. These data, demonstrating the downregulation of the mRNA and protein expression levels of GIMAP5 and GIMAP6 in the tumor tissues and blood of patients with HCC, suggested the involvement of GIMAP5 and GIMAP6 in the pathogenesis of HCC, and indicate their possible use as diagnostic markers for HCC.

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“…The importance of the microenvironment in HCC (see pages [14][15] has led to proposals that simple blood test estimates of inflammation are important patient prognosticators.…”

Section: Newer Hepatocellular Carcinoma Tumor Markers Proteomics CImentioning

confidence: 99%

Understanding Liver Cancer

Carr

2014

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HCC: current surgical treatment concepts

Abstract: The improvement of survival in HCC patients after surgical treatment results from refinements in surgical technique and better identification of adverse prognostic factors.

Cited by 59 publications

References 145 publications

Laparoscopic liver resection for hepatocellular carcinoma in cirrhotic patients: 10-year single-center experience

Laparoscopic liver resection for hepatocellular carcinoma in cirrhotic patients: 10-year single-center experience

Dysregulation of GTPase IMAP family members in hepatocellular cancer

Understanding Liver Cancer

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