Preoperative Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Prospective Analysis

Strickland, Kyle C.; Vivero, Marina; Jo, Vickie Y.; Lowe, Alarice; Hollowell, Monica; Qian, Xiaohua; Wieczorek, Tad J.; French, Christopher A.; Teot, Lisa A.; Sadow, Peter M.; Alexander, Erik K.; Cibas, Edmund S.; Barletta, Justine A.; Krane, Jeffrey F.

doi:10.1089/thy.2016.0280

Cited by 110 publications

(141 citation statements)

References 18 publications

Supporting

Mentioning

126

Contrasting

Order By: Relevance

“…While 38.5% of Hahn's cases were EFVPTC, and 65% of these were noninvasive, they did not divide their findings by these subgroups 7. Other studies have also found that indeterminate TBS diagnoses are seen in the majority of NIFTP cases [20][21][22]. Other studies have also found that indeterminate TBS diagnoses are seen in the majority of NIFTP cases [20][21][22].…”

mentioning

confidence: 90%

Does noninvasive follicular thyroid neoplasm with papillary‐like nuclear features have distinctive features on sonography?

Brandler

Yee

Zhou

et al. 2017

Diagnostic Cytopathology

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 90%

Does noninvasive follicular thyroid neoplasm with papillary‐like nuclear features have distinctive features on sonography?

Brandler

Yee

Zhou

et al. 2017

Diagnostic Cytopathology

View full text Add to dashboard Cite

show abstract

“…Cytopathologic ability to distinguish NIFTP from invasive FVPTC is made difficult as both lesions may demonstrate a microfollicular growth pattern and nuclear features of PTC, including nuclear enlargement, pallor, crowding, and grooves 12. However cytological features can be used to help exclude a diagnosis of NIFTP in favor of a classical papillary cancer diagnosis.…”

Section: Introductionmentioning

confidence: 99%

AHNS Series: Do you know your guidelines? AHNS Endocrine Section Consensus Statement: State‐of‐the‐art thyroid surgical recommendations in the era of noninvasive follicular thyroid neoplasm with papillary‐like nuclear features

et al. 2018

Self Cite

View full text Add to dashboard Cite

The newly introduced pathologic diagnosis of noninvasive follicular thyroid neoplasm with papillary‐like nuclear features (NIFTP) will result in less bilateral thyroid surgery as well as deescalation in T4 suppressive and radioactive iodine treatment. Although, NIFTP is a nonmalignant lesion that has nuclear features of some papillary malignancies, the challenge for the surgeon is to identify a lesion as possibly NIFTP before the pathologic diagnosis. NIFTP, due to its reduction of overall rates of malignancy, will result in the initial surgical pendulum swinging toward lobectomy instead of initial total thyroidectomy. This American Head and Neck Society endocrine section consensus statement is intended to inform preoperative evaluation to attempt to identify those patients whose final pathology report may ultimately harbor NIFTP and can be offered a conservative surgical plan to assist in cost‐effective, optimal management of patients with NIFTP.

show abstract

“…The noninvasive EFVPTC lesions having follicular growth pattern, particular microscopic architecture and nuclear features of PTC with low risk of malignancy have been reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) (Nikiforov et al, 2016, Strickland et al, 2016). The assessment of such borderline lesions is challenging for clinical practice as in this “grey zone” the intra-observer agreement may vary from 17% to 100% (Elsheikh et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Programmed Death - Ligand 1 Expression Distinguishes Invasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma from Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features

Polyakova

MacMillan

et al. 2017

EBioMedicine

View full text Add to dashboard Cite

BackgroundThe noninvasive Encapsulated follicular variant of papillary thyroid cancer (EFVPTC) has been reclassified as Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) without a significant risk for malignant behavior. However the evaluation remains a challenge for clinicians. We sought to determine whether programmed death-ligand 1 (PD-L1) expression may serve as a biomarker to predict invasiveness of EFVPTC and assist to distinguish these neoplasms from NIFTP.MethodsImmunohistochemical staining of PD-L1 expression was performed in sections of 174 Formalin-fixed paraffin-embedded (FFPE) tissue blocks from surgery removed thyroid nodules.ResultsCytoplasmic PD-L1 expression was significantly increased in invasive EFVPTC (4.76 ± 1.49) as compared to NIFTP (3.06 ± 2.16, p < 0.001). Increased cytoplasmic PD-L1 expression was associated with invasiveness in EFVPTC (p < 0.001); PD-L1 positive EFVPTC cases were at 3.16 folds higher risk in developing invasion than the PD-L1 negative cases. No significant difference in cytoplasmic PD-L1 expression was observed between NIFTP and benign nodules.ConclusionPD-L1 expression may serve as a useful biomarker in predicting invasiveness of EFVPTC and distinguishing NIFTP from invasive EFVPTC. To our knowledge this is the first report suggesting the application of a protein biomarker to confirm NIFTP as benign indolent neoplasms.

show abstract

Preoperative Cytologic Diagnosis of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: A Prospective Analysis

Cited by 110 publications

References 18 publications

Does noninvasive follicular thyroid neoplasm with papillary‐like nuclear features have distinctive features on sonography?

Does noninvasive follicular thyroid neoplasm with papillary‐like nuclear features have distinctive features on sonography?

AHNS Series: Do you know your guidelines? AHNS Endocrine Section Consensus Statement: State‐of‐the‐art thyroid surgical recommendations in the era of noninvasive follicular thyroid neoplasm with papillary‐like nuclear features

Programmed Death - Ligand 1 Expression Distinguishes Invasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma from Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features

Contact Info

Product

Resources

About