2020
DOI: 10.1186/s12885-020-07003-z
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Preoperative clinical characteristics scoring system for differentiating uterine leiomyosarcoma from fibroid

Abstract: Background: Morcellation may lead to intraperitoneal spread of tumor cells, thus making prognosis of undiagnosed uterine leiomyosarcoma (ULMS) worse. However, preoperative diagnosis of ULMS remains challenging. This study aimed to design a preoperative clinical characteristics scoring system for differentiating ULMS from uterine fibroid. Methods: This study enrolled 45 ULMS patients and 180 uterine fibroid patients in Peking Union Medical College Hospital from January 2013 to December 2018. Results: The incide… Show more

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Cited by 22 publications
(24 citation statements)
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“…In women under 40 years, between 40 and 49 years, and over 49 years old, reported prevalence of occult LMS were 0%, 0.15%, and 1.2%, respectively, 16 which suggests that age may be significant. Previous studies have also reported that an age of ≥ 40 or ≥ 45 years independently predicted LMS, 4,17 and our findings concur with these reports. In the present study, patients in LMS group were older than those in the LM group (54 vs 44 years old, P < 0.001), and an age of ≥ 50 years independently predicted the presence of LMS (Table 3).…”
Section: Discussionsupporting
confidence: 93%
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“…In women under 40 years, between 40 and 49 years, and over 49 years old, reported prevalence of occult LMS were 0%, 0.15%, and 1.2%, respectively, 16 which suggests that age may be significant. Previous studies have also reported that an age of ≥ 40 or ≥ 45 years independently predicted LMS, 4,17 and our findings concur with these reports. In the present study, patients in LMS group were older than those in the LM group (54 vs 44 years old, P < 0.001), and an age of ≥ 50 years independently predicted the presence of LMS (Table 3).…”
Section: Discussionsupporting
confidence: 93%
“…4 This enzyme is involved in the metabolism of cancer cells and causes these cells to suppress and evade the immune system by altering tumor microenvironments. 26 Although studies have reported significant differences between LDH levels in LM and LMS patients, 4,15,21 the cutoff values used varied and no LDH value has been defined for LMS. In these studies, LDH levels of level ≥ 193 U/L, > 279 U/L, and ≥ 300 U/L were reported to independently predict the presence of uterine sarcoma preoperatively.…”
Section: Discussionmentioning
confidence: 99%
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“…In the area of gynecological cancer, several studies have reported that high NLR is associated with OS and DFS in patients with ovarian, endometrial, or cervical cancer [ 21 , 22 , 23 , 24 ]. In uterine sarcoma, some studies have reported that preoperative NLR levels are more useful than CA125 levels for the preoperative differential diagnosis of benign and malignant tumors [ 25 , 26 ]. To the best of our knowledge, there have been only two papers on NLR as a prognostic marker.…”
Section: Discussionmentioning
confidence: 99%
“…Some studies have suggested a new scoring system by combining both NLR and PLR as an independent prognostic factor for OS and DFS [ 20 , 28 ]. Liang et al [ 26 ] defined the combination of NLR and PLR as CNP in soft tissue sarcoma patients. These patients were classified into three CNP groups (both high NLR and high PLR were allocated a score of 2, patients with only one elevated value were allocated a score of 1, patients with both low NLR and low PLR were allocated a score of 0).…”
Section: Discussionmentioning
confidence: 99%