Preoperative circulating platelet, neutrophil, and lymphocyte counts predict survival in oral cancer

Diao, Pengfei; Wu, Yaping; Ge, Huan; Zhang, Wei; Huang, Rong; Wang, Yanling; Cheng, Jie

doi:10.1111/odi.13049

Cited by 24 publications

(33 citation statements)

References 30 publications

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“…Recent studies have shown that various pro-inflammatory mediators are associated with tumor progression at different stages of head and neck squamous cell carcinoma (HNSCC), and contribute to cancer cell proliferation, neovascularization, distant metastasis, and drug resistance. In previous studies, complex inflammation was demonstrated to play an essential role in the progression and metastasis of HNSCC (10)(11)(12)(13).…”

Section: Discussionmentioning

confidence: 99%

Pre-treatment circulating neutrophil count is an independent prognostic factor in oropharyngeal cancer

Liu

et al. 2020

Ann Transl Med

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Background: Oropharyngeal cancer (OPC) is a type of head and neck squamous cell cancer, the incidence of which has increased in recent years. Many studies have reported a variety of prognostic markers of OPC, but they are either expensive or difficult to obtain. Therefore, we retrospectively studied the prognostic value of circulating neutrophil count (CNC) in patients with OPC, with the aim of providing a theoretical basis for further prognostic stratification. Methods:The clinicopathological data of 153 patients diagnosed with OPC from January 2010 to June 2017 were retrospectively analyzed. The CNC of each patient was measured before treatment. Then, the relationship between CNC and the clinicopathological characteristics of the patients was analyzed.The receiver operating characteristic (ROC) curve was used to calculate the cutoff value of CNC. The cox proportional hazards model was used to perform univariate and multivariate analysis of the relevant prognostic factors to determine the factors related to overall survival (OS) and progression-free survival (PFS). Results:The cutoff value for CNC was 4.48. Neutrophilia was significantly associated with disease stage, P16 status, and the type of therapy. In the univariate and multivariate analyses, CNC was found to be correlated with OS and PFS. Increased neutrophil count was predictive of poor OS (P<0.001) and PFS (P=0.001). Neutrophil count was an independent risk factor for OS (HR =2.09, 95% CI: 1.25-3.51, P=0.005) and PFS (HR =1.78, 95% CI: 1.10-2.88, P=0.02) in patients with OPC.Conclusions: Pre-treatment CNC is an independent prognostic factor for OPC.

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Section: Discussionmentioning

confidence: 99%

Pre-treatment circulating neutrophil count is an independent prognostic factor in oropharyngeal cancer

Liu

et al. 2020

Ann Transl Med

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“…12,27,28 The important role of unresolved inflammation in HNSCC progression and metastasis is well established in previous studies. 12,17,27,28 Firstly, elevated blood neutrophil counts in an inflammatory microenvironment have been shown to contribute to tumor angiogenesis. It induces the resistance to antivascular endothelial growth factor (anti-VEGF) therapy.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, multiple inflammatory markers have been long since emerging as surrogate biomarkers and as prognostic indicators for patients with oral cavity/oropharyngeal carcinoma and other solid cancers, 14,15 such as neutrophil, lymphocyte, monocyte, platelet counts, either as individual values or ratios to each other. [17][18][19][20] As it is well known, platelet count (PLT) is critical in coagulation and inflammation. Moreover, activated platelets are linked to increased cancer risk through various mechanisms.…”

Section: Introductionmentioning

confidence: 99%

“…The prognostic value is higher than that of either index alone. 20 Despite the recognized contribution of hematologic, inflammatory and nutritional parameters, 7,17,26 several crucial puzzles were remained to be unsolved: so far, there was limited data in hypopharyngeal and laryngeal cancer. Besides, most research focused on patients with inoperative head and neck cancer or patients received definitive chemoradiation therapy.…”

Section: Introductionmentioning

confidence: 99%

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<p>Prognosis Value of Platelet Counts, Albumin and Neutrophil-Lymphocyte Ratio of Locoregional Recurrence in Patients with Operable Head and Neck Squamous Cell Carcinoma</p>

Ye¹,

Liao²,

Jiang³

et al. 2020

CMAR

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Background: Peripheral blood inflammation factor neutrophil-lymphocyte ratio (NLR), platelet count (PLT) and nutritional factor serum albumin (ALB) have been proposed as prognostic markers of head and neck squamous carcinoma cancer (HNSCC) in recent years. In the current study, nomogram predict models based on pre-treatment hematological parameters and a modified risk-stratified score system have been built. Methods: A total of 197 patients with oropharyngeal, hypopharyngeal and laryngeal cancers receiving multimodality treatment between 2012 and 2014 were included. The pre-treatment ALB, neutrophil, lymphocyte and platelet count (PLT) were detected. Cancer-specific survival and locoregional recurrence (LRC) by 5 years' follow-up in the cases were obtained. To integrate clinical characteristics, we propose a modified risk-stratified score system. Kaplan-Meier method, proportional hazards COX model, logistic models were used to establish nomograms within external validation. Results: Five-year LRC was decreased (p=0.004) for 140 patients with pre-treatment NLR <2.77. Five-year LRC and 5-year cancer-specific survival were decreased (p=0.031, p=0.021) with pre-treatment PLT ≥248×10 9 /L. Comparison of univariate parametric models demonstrated that pre-treatment NLR evaluation and PLT>248×10 9 /L were better among tested models. On Bayesian information criteria (BIC) analysis, the optimal prognostic model was then used to develop nomograms predicting 3-and 5-year LRC. The external validation of this predictive model was confirmed in 57 patients from another hospital. Conclusion: Pre-treatment NLR elevation and PLT>248×10 9 /L are promising predictors of prognosis in patients with operable HNSCC. Nomograms based on the pre-treatment hematological markers and modified risk-stratified score system provide distinct risk stratifications. There results provided the feasibility of anti-inflammatory and antiplatelet treatments for HNSCC patients.

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“…Previous studies suggested that preoperative peripheral neutrophil and lymphocyte counts were correlated with survival in oral cancer. 12,13 But the prognostic value of inflammatory markers has not been fully elucidated in patients with advanced OSCC undergoing CRT. Thus, it is necessary to assess the available pretreatment parameters in order to develop a prognostic model for the prediction of survival outcomes in OSCC patients.…”

Section: Introductionmentioning

confidence: 99%

<p>Inflammatory Marker Predicts Outcome of Oral Squamous Cell Carcinoma Receiving Chemo-Radiotherapy</p>

Sun

Gao

2020

CMAR

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Background: Inflammation is involved in the progression of oral squamous cell carcinoma. We therefore postulate that a blood-based inflammatory marker, the neutrophil-tolymphocyte ratio, could help to predict the prognosis in patients with oral squamous cell carcinoma receiving chemo-radiotherapy, and build a prognostic nomogram. Methods: In 111 cases of oral squamous cell carcinoma, several baseline variables, including inflammatory markers and lactate dehydrogenase, were measured within the week of chemoradiotherapy initiation as predictors of mortality and separate risk scores were developed. Results: Dichotomized neutrophil-to-lymphocyte ratio was found to be associated with AJCC stage (p<0.001). Patients with oral squamous cell carcinoma with a low neutrophil-tolymphocyte ratio survived longer than those with a high neutrophil-to-lymphocyte ratio (overall survival HR=2.39, 95% CI 1.24-4.61, p=0.009). The Harrell's concordance (C)-statistic of the nomogram was 0.74 and the calibration curve demonstrated the goodness of fit. Conclusion: The inflammatory marker neutrophil-to-lymphocyte ratio, obtained before chemo-radiotherapy, was an independent factor of survival prediction for oral squamous cell carcinoma. The nomogram incorporating immunological markers could more accurately predict individualized survival probability than the existing models. These findings are significant for the creation of personalized treatment strategies in the clinical setting.

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Preoperative circulating platelet, neutrophil, and lymphocyte counts predict survival in oral cancer

Cited by 24 publications

References 30 publications

Pre-treatment circulating neutrophil count is an independent prognostic factor in oropharyngeal cancer

Pre-treatment circulating neutrophil count is an independent prognostic factor in oropharyngeal cancer

<p>Prognosis Value of Platelet Counts, Albumin and Neutrophil-Lymphocyte Ratio of Locoregional Recurrence in Patients with Operable Head and Neck Squamous Cell Carcinoma</p>

<p>Inflammatory Marker Predicts Outcome of Oral Squamous Cell Carcinoma Receiving Chemo-Radiotherapy</p>

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