<p>Prognosis Value of Platelet Counts, Albumin and Neutrophil-Lymphocyte Ratio of Locoregional Recurrence in Patients with Operable Head and Neck Squamous Cell Carcinoma</p>

Abstract

Background: Peripheral blood inflammation factor neutrophil-lymphocyte ratio (NLR), platelet count (PLT) and nutritional factor serum albumin (ALB) have been proposed as prognostic markers of head and neck squamous carcinoma cancer (HNSCC) in recent years. In the current study, nomogram predict models based on pre-treatment hematological parameters and a modified risk-stratified score system have been built. Methods: A total of 197 patients with oropharyngeal, hypopharyngeal and laryngeal cancers receiving multimodality treatment between 2012 and 2014 were included. The pre-treatment ALB, neutrophil, lymphocyte and platelet count (PLT) were detected. Cancer-specific survival and locoregional recurrence (LRC) by 5 years' follow-up in the cases were obtained. To integrate clinical characteristics, we propose a modified risk-stratified score system. Kaplan-Meier method, proportional hazards COX model, logistic models were used to establish nomograms within external validation. Results: Five-year LRC was decreased (p=0.004) for 140 patients with pre-treatment NLR <2.77. Five-year LRC and 5-year cancer-specific survival were decreased (p=0.031, p=0.021) with pre-treatment PLT ≥248×10 9 /L. Comparison of univariate parametric models demonstrated that pre-treatment NLR evaluation and PLT>248×10 9 /L were better among tested models. On Bayesian information criteria (BIC) analysis, the optimal prognostic model was then used to develop nomograms predicting 3-and 5-year LRC. The external validation of this predictive model was confirmed in 57 patients from another hospital. Conclusion: Pre-treatment NLR elevation and PLT>248×10 9 /L are promising predictors of prognosis in patients with operable HNSCC. Nomograms based on the pre-treatment hematological markers and modified risk-stratified score system provide distinct risk stratifications. There results provided the feasibility of anti-inflammatory and antiplatelet treatments for HNSCC patients.

Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis

“…Albumin, a protein that exerts important homeostatic effects such as maintenance of the osmotic colloid pressure, intravascular transport of molecules, lipid metabolism, thrombosis and inflammation, is classically considered as a biomarker of malnutrition and poor health status [88,89]. Hypoalbuminemia has been described as a negative prognostic factor in several diseases, [89][90][91][92]. Furthermore, low serum albumin concentrations have been shown to be associated with the severity of chronic inflammatory diseases, inflammatory bowel disease and diabetes mellitus [93], cirrhosis [94], as well as with the severity of surgical trauma [95], acute diseases [96] and sepsis [97].…”

Geriatric nutritional risk index as a prognostic marker of pTNM-stage I and II esophageal squamous cell carcinoma after curative resection

“…Serum albumin is a clinically relevant indicator of nutritional status, such as malnutrition and cachexia [3,4]. Additionally, hypoalbuminemia is often associated with systemic inflammation and impaired host immune responses [5,6]. Systemic inflammation promotes tumor progression and metastasis [7].…”

Pretreatment Blood Markers in the Prediction of Occult Neck Metastasis: A 10-Year Retrospective Study

“…Other inflammatory biomarkers have also been described as prognostic factors for several malignancies such as MLR [ 10 , 11 ], PLR [ 15 , 42 ], RDW [ 12 ], MPV [ 43 ] and fibrinogen [ 12 ]. Therefore, in our study, we decided to assess the predictive ability of such inflammatory biomarkers in accurately staging the clinically negative neck, additionally to NLR.…”

“…Numerous studies have shown that changes occur across blood cell lines, and their ratios, during carcinogenesis [9]. Inflammatory blood markers like neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR) red cell width distribution (RDW), mean platelet volume (MPV) and fibrinogen values have been described as prognostic factors for several malignancies [10][11][12][13][14][15][16][17]. Some authors have even demonstrated that NLR could play a role in predicting occult nodal metastasis in early-stage tongue tumors [3,6].…”