Geriatric nutritional risk index as a prognostic marker of pTNM-stage I and II esophageal squamous cell carcinoma after curative resection

Hirahara, Noriyuki; Matsubara, Takeshi; Fujii, Yusuke; Kaji, Shunsuke; Hyakudomi, Ryoji; Yamamoto, Tetsu; Uchida, Yuki; Miyazaki, Yoshiko; Ishitobi, Kazunari; Yasunari, Kenichi; Tajima, Yoshitsugu

doi:10.18632/oncotarget.27670

Cited by 17 publications

(9 citation statements)

References 29 publications

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“…However, in the current study, the optimal GNRI cut-off value of 93.7 was determined based on the ROC analysis. This value is within the range of 91.959 to 104.25 reported in previous studies that determined the GNRI cut-off using ROC analysis (Hirahara et al, 2020a(Hirahara et al, , 2020bIde et al, 2021;Ruan et al, 2021). These findings highlight preoperative GNRI as a useful prognostic indicator in patients undergoing radical cancer resection.…”

Section: Discussionsupporting

confidence: 82%

Prognostic impact of preoperative Geriatric Nutritional Risk Index in oral squamous cell carcinoma

et al. 2022

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Objectives To investigate the prognostic impact of preoperative Geriatric Nutritional Risk Index (GNRI) values in older adults undergoing radical surgery for oral squamous cell carcinoma (OSCC). Subjects and methods This retrospective study included 61 patients ≥65 years old with OSCC (43 men, 18 women; age: 72.1 ± 5.4 years) who underwent radical surgery between 2013 and 2020. Factors influencing overall survival (OS) and disease‐free survival (DFS) were examined. Results Receiver operating characteristic curve analysis indicated that the optimal GNRI value for classifying patients into low‐GNRI (<93.7; OS: n = 19 [31.1%], DFS: n = 42 [68.9%]) and high‐GNRI groups (≥93.7; OS, n = 19 [31.1%]; DFS, n = 42 [68.9%]) was 93.7. OS and DFS rates were significantly lower in the low‐GNRI group than in the high‐GNRI group. Univariate analysis indicated that alcohol use, preoperative serum C‐reactive protein level, lymphatic invasion, postoperative treatment, and GNRI were significantly correlated with OS, while lymphatic invasion, postoperative treatment, and GNRI were significantly correlated with DFS. In multivariate analysis, only GNRI was significantly correlated with OS. DFS and postoperative treatment were independent predictors of DFS. Conclusions Preoperative GNRI may be a significant prognostic factor in older adults with OSCC. GNRI assessment and nutritional intervention may improve prognosis in patients at high nutritional risk.

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Section: Discussionsupporting

confidence: 82%

Prognostic impact of preoperative Geriatric Nutritional Risk Index in oral squamous cell carcinoma

et al. 2022

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“…Aging itself can reduce physiological recuperative power, aging is an independent risk factor for both in-hospital morbidity and mortality after colorectal surgery 2 , 3 . Recently, it has been widely accepted that GNRI (Geriatric Nutritional Risk Index) is strongly associated with mortality in elderly patients with various cancers 4 – 6 . However, as far as we know, there are few reports on the prognostic significance of GNRI in patients with colorectal cancer.…”

Section: Introductionmentioning

confidence: 99%

The preoperative geriatric nutritional risk index (GNRI) is an independent prognostic factor in elderly patients underwent curative resection for colorectal cancer

Hayama

Hashiguchi

Ozawa

et al. 2022

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The world is becoming longer-lived, and the number of elderly colorectal cancer patients is increasing. It is very important to identify simple and inexpensive postoperative predictors in elderly colorectal cancer patients. The geriatric nutritional risk index (GNRI) is a marker of systemic nutrition and is associated with poor survival in various kinds of cancers. A few reports have investigated recurrence factors using preoperative GNRI with CRC (colorectal cancer) patients. This study aimed to investigate whether preoperative GNRI is associated with recurrence-free survival (RFS) and overall survival (OS) in elderly patients with CRC. This study retrospectively enrolled 259 patients with Stage I–III CRC who were more than 65 years old and underwent curative surgery at a single institution in 2012–2017. We classified them into low GNRI (RFS: ≤ 90.5, OS ≤ 101.1) group and high GNRI (RFS: > 90.5, OS > 101.1) group. Multivariable analyses showed low GNRI group was an independent risk factor for 3-year RFS (P = 0.006) and OS (P = 0.001) in the patients with CRC. Kaplan–Meier analysis showed 3-year RFS and 3-year OS were significantly worse in the low GNRI group than in high GNRI group (p = 0.001, 0.0037). A low-preoperative GNRI was significantly associated with a poor prognosis in elderly CRC patients.

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“…In clinical practice, TNM staging alone cannot be used to predict clinical outcomes, since it only classifies patients according to postoperative pathological outcomes and does not include nutritional or inflammatory status [ 29 , 30 ]. Thus, novel relevant prognostic predictors are needed to improve prognosis with individual treatment for gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Influence of nutrition on stage-stratified survival in gastric cancer patients with postoperative complications

et al. 2022

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Background: We assessed the relationship between preoperative prognostic nutritional index (PNI) and short- and long-term outcomes among gastric cancer patients because the clinical significance of PNI in these patients remains controversial. Materials and Methods: We retrospectively reviewed the medical records of 434 consecutive patients who underwent curative laparoscopic gastrectomy for gastric cancer. Results: Patients with postoperative complications had a significantly poorer overall survival (OS) than those without. On multivariate analyses, postoperative complications were independently associated with PNI value and operative procedure type. In the low PNI group ( n = 118), those with postoperative complications experienced significantly poorer OS than those without complications. Among the low PNI group with pTNM stage I and II disease, those with postoperative complications experienced significantly worse OS than those without complications. However, among the high PNI group and patients with stage II and III disease in the low PNI group, OS was similar with respect to postoperative complications. Conclusions: The present study confirmed that long-term prognosis was unaffected by postoperative complications in well-nourished gastric cancer patients. In addition, preoperative nutritional status and postoperative complications, may be crucial in determining the prognosis of gastric cancer, especially in early-stage cancer.

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Geriatric nutritional risk index as a prognostic marker of pTNM-stage I and II esophageal squamous cell carcinoma after curative resection

Cited by 17 publications

References 29 publications

Prognostic impact of preoperative Geriatric Nutritional Risk Index in oral squamous cell carcinoma

Prognostic impact of preoperative Geriatric Nutritional Risk Index in oral squamous cell carcinoma

The preoperative geriatric nutritional risk index (GNRI) is an independent prognostic factor in elderly patients underwent curative resection for colorectal cancer

Influence of nutrition on stage-stratified survival in gastric cancer patients with postoperative complications

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