Preoperative Aspirin Administration Improves Oxygenation in Patients Undergoing Coronary Artery Bypass Grafting

Gerrah, Rabin; Elami, Amir; Stamler, Alon; Smirnov, Asya; Stoeger, Zeev

doi:10.1378/chest.127.5.1622

Cited by 21 publications

(28 citation statements)

References 25 publications

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“…More recent publications revealed no impact of aspirin on bleeding and transfusions, especially when lower doses were used [9,10]. The predominant goal of platelet blocking before surgical revascularization (both for OPCAB and on-pump CABG) is myocardial perfusion protection during surgery and [11,12]. In our cohort there was no significant difference between ASA resistant patients and ASA responders in terms of ischemia markers level during the postoperative observation period.…”

Section: Discussionmentioning

confidence: 43%

The effect of off-pump coronary artery bypass grafting on platelet activation in patients on aspirin therapy until surgery day☆

Suwalski¹,

Suwalski²,

Filipiak‬³

et al. 2008

European Journal of Cardio-Thoracic Surgery

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Section: Discussionmentioning

confidence: 43%

The effect of off-pump coronary artery bypass grafting on platelet activation in patients on aspirin therapy until surgery day☆

Suwalski¹,

Suwalski²,

Filipiak‬³

et al. 2008

European Journal of Cardio-Thoracic Surgery

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“…[12][13][14][15][16][17] Other evidence suggests that aspirin improves postoperative gas exchange in patients undergoing cardiac surgery 18 and reduces thromboxane B2 production during cardiopulmonary bypass leading to lung protection. 19 Animal models have shown that aspirin may also reduce the risk of transfusion-related acute lung injury by modulating platelet-neutrophil aggregation in the lung.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Aspirin Use and Lung Injury After Aortic Valve Replacement Surgery

Mazzeffi

Kassa²,

Gammie³

et al. 2015

Anesthesia &Amp; Analgesia

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“…Generally, ASA is well tolerated even in acutely ill, hospitalised patients in whom ASA is often continued during the hospitalisation. As an example, in a study of ASA use up to the time of cardiac surgery, its continuation was not associated with an increased need for transfusion therapies 43. Nevertheless, there may be injury associated with the administration of ASA.…”

Section: Discussionmentioning

confidence: 99%

Lung Injury Prevention with Aspirin (LIPS-A): a protocol for a multicentre randomised clinical trial in medical patients at high risk of acute lung injury

et al. 2012

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IntroductionAcute lung injury (ALI) is a devastating condition that places a heavy burden on public health resources. Although the need for effective ALI prevention strategies is increasingly recognised, no effective preventative strategies exist. The Lung Injury Prevention Study with Aspirin (LIPS-A) aims to test whether aspirin (ASA) could prevent and/or mitigate the development of ALI.Methods and analysisLIPS-A is a multicentre, double-blind, randomised clinical trial testing the hypothesis that the early administration of ASA will result in a reduced incidence of ALI in adult patients at high risk. This investigation will enrol 400 study participants from 14 hospitals across the USA. Conditional logistic regression will be used to test the primary hypothesis that early ASA administration will decrease the incidence of ALI.Ethics and disseminationSafety oversight will be under the direction of an independent Data and Safety Monitoring Board (DSMB). Approval of the protocol was obtained from the DSMB prior to enrolling the first study participant. Approval of both the protocol and informed consent documents were also obtained from the institutional review board of each participating institution prior to enrolling study participants at the respective site. In addition to providing important clinical and mechanistic information, this investigation will inform the scientific merit and feasibility of a phase III trial on ASA as an ALI prevention agent. The findings of this investigation, as well as associated ancillary studies, will be disseminated in the form of oral and abstract presentations at major national and international medical specialty meetings. The primary objective and other significant findings will also be presented in manuscript form. All final, published manuscripts resulting from this protocol will be submitted to Pub Med Central in accordance with the National Institute of Health Public Access Policy.

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Preoperative Aspirin Administration Improves Oxygenation in Patients Undergoing Coronary Artery Bypass Grafting

Cited by 21 publications

References 25 publications

The effect of off-pump coronary artery bypass grafting on platelet activation in patients on aspirin therapy until surgery day☆

The effect of off-pump coronary artery bypass grafting on platelet activation in patients on aspirin therapy until surgery day☆

Preoperative Aspirin Use and Lung Injury After Aortic Valve Replacement Surgery

Lung Injury Prevention with Aspirin (LIPS-A): a protocol for a multicentre randomised clinical trial in medical patients at high risk of acute lung injury

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