The effect of off-pump coronary artery bypass grafting on platelet activation in patients on aspirin therapy until surgery day☆

Abstract

Aspirin therapy continued until surgery day does not protect against acute platelet activation in patients after OPCAB.

Aspirin versus clopidogrel after surgical offpump coronary revascularization – a prospective, randomized, head-to-head pilot trial

“…Early administration of clopidogrel seems to play a key role as over-reactivity of platelets due to surgical trauma which occurs shortly after surgery and its suppression with a high dose of aspirin (300 mg 48 hours after chest closure) is not effective. Those results were published by authors elsewhere [14]. The hypercoagulation phenomenon is strongly expressed in patients who were operated with off-pump technique [15].…”

Effects of preoperative aspirin on perioperative platelet activation and dysfunction in patients undergoing off-pump coronary artery bypass graft surgery: A prospective randomized study

“…However, both of these studies are limited by their retrospective nature. In a prospective observational clinical study, Suwalski et al [27] investigated the effect of preoperative aspirin use with a myocardial enzyme and platelet function analyzer (PFA-100 ® ; Dade Behring, Germany). Their findings suggested that preoperative aspirin use did not protect against acute platelet activation in OPCAB.…”

Czynniki ryzyka zwiększonego drenażu klatki piersiowej u pacjentów poddawanych operacji pomostowania aortalno-wieńcowego bez użycia krążenia pozaustrojowego

“…This affects final clinical outcome of treatment as patients undergoing re-exploration due to postoperative bleeding have higher mortality and longer hospitalization [1,4,5]. To achieve reliable results we eliminated two risk factors.…”

“…Wykonano również regresję logistyczną, w której mierzalnym parametrem był drenaż krwi w pierwszej dobie po operacji. Za istotne statystycznie uznano parametry, których p było niższe od 0,05. www.journals.viamedica.pl/folia_cardiologica Ireneusz Haponiuk, Komentarz analiza danych dotyczących tak powszechnego czynnika ryzyka krwawień pooperacyjnych, jakim jest standardowe leczenie kwasem acetylosalicylowym u pacjentów z przewlekłą chorobą wieńcową, jak należy sądzić, także w badanej grupie [5].…”

“…Moreover, the mortality is higher if drainage excides 2 mL/kg in the first 2 hours or the amount of blood excides 200 mL/h in any of the first 6 postoperative hours. Drainage exceeding 495 mL/24 h is also a negative prognostic factor for the need of transfusion, hypotension, organ failure, prolonged ventilation, dialysis, and in-hospital infections [5]. Conservative treatment is also possible and it could be considered shortly after the operation.…”