Preoperative Alterations of Interleukin-6 levels During Surgical Removal of Impacted Lower Third Molar

Abstract

Aims: The aim of the study is to assess the blood levels of (interleukin-6) at different intervals of time after surgical removal of impacted lower third molars.. Materials and Methods: The study group comprised 26 patients with impacted lower third molars .All extractions were performed under local anaesthesia using the inferior alveolar nerve block together with vestibular infiltration. A buccal full thickness two sided mucoperiosteal flap was raised. Sterile low-speed straight hand pieces and sterile distilled water were used for ostectomy. After tooth removal the wound was closed with 3-0 black silk suture. Three blood samples were drawn from each patient; one before the operation, the second 2hr. post operation and the third 24hr. post operation. The blood samples were collected through venipuncture, serum separated and stored in at-20ºC. Analysis was performed using the Enzyme linked Immunosourbant assay (ELISA). Results: The level of IL-6, in this study, showed an increase following surgery, in comparison with the level before operation. This increase in the level of Interleukin-6 remained high until 24hr after operation. Conclusion: Interleukin-6 (IL-6) is higher after surgical extraction of lower third molars and remained with high levels to 24hr. after operation.