Preoperative 5-fluorouracil and radiation therapy for locally advanced breast cancer

Escandón, Joseph M.; Dunnington, Gary L.; Silberman, Howard; Florentine, Barbara D.; Spicer, Darcy; Formenti, Silvia C.

doi:10.1016/s0002-9610(97)00198-0

Cited by 29 publications

(30 citation statements)

References 17 publications

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“…Patients with LABC are at significant risk for locoregional and systemic disease; thus, multimodal therapy has been used in a variety of strategies (1)(2)(3)(4)(5). The National Cancer Institute used chemotherapy or chemotherapy with hormonal synchronization to maximal response in a neoadjuvant prospective trial of 107 patients (1).…”

Section: Discussionmentioning

confidence: 99%

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Thermochemoradiotherapy Improves Oxygenation in Locally Advanced Breast Cancer

Jones

Prosnitz

Dewhirst

et al. 2004

Clinical Cancer Research

129

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Purpose: The purpose of this research was to evaluate toxicity, response, and changes in oxygenation (pO 2 ) in patients with locally advanced breast cancer (LABC) treated with concurrent taxol, hyperthermia (HT), and radiation therapy (RT) followed by mastectomy.Experimental Design: Eighteen patients with LABC were enrolled from October 1995 through February 1999. Treatment consisted of taxol (175 mg/m 2 ) given every 3 weeks for three cycles. Radiation therapy included the breast and regional nodes with a dose of 50 Gy, followed by a boost to 60 -65 Gy for those not undergoing surgery. Mastectomy was performed for patients deemed resectable after this neoadjuvant program. HT was administered twice per week. Oxygenation was measured before the first HT treatment and 24 h after the first HT treatment.Results: Fifteen of 18 patients responded, 6 with a clinical complete response, 9 with a partial clinical response, and 3 nonresponders. Thirteen underwent mastectomy with 3 pathological complete responses. Tumor hypoxia was present in 8 of 13 patients (pO 2 ‫؍‬ 4.7 ؎ 1.2 mmHg). Five patients had well-oxygenated tumors (pO 2 ‫؍‬ 27.6 ؎ 7.8 mmHg). Patients with well-oxygenated tumors before treatment as well as those with significant reoxygenation had a favorable clinical response. Tumor reoxygenation appeared to be temperature dependent and associated with the lower thermal doses.Conclusions: This novel therapeutic program resulted in a high response rate in patients with LABC. Hyperthermia may offer a strategy for improving tumor reoxygenation with consequent treatment response. However, the effect of hyperthermia on tumor reoxygenation appears to depend on thermal dose and requires additional investigation.

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Section: Discussionmentioning

confidence: 99%

“…Many different multimodality regimens are currently in clinical use (1)(2)(3)(4)(5). The 5-year disease-free survival is typically in the 30 -50% range, despite aggressive treatment.…”

Section: Introductionmentioning

confidence: 99%

Thermochemoradiotherapy Improves Oxygenation in Locally Advanced Breast Cancer

Jones

Prosnitz

Dewhirst

et al. 2004

Clinical Cancer Research

129

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“…The rationale for this treatment approach is that tumor cells surviving after chemotherapy are sterilized by additional irradiation due to synergistic lethal effects. Combined preoperative chemo-/radiotherapy was also introduced to achieve better tumor shrinkage in inoperable breast cancer [31]. In order to identify patients who could potentially be treated without subsequent surgery, preoperative chemotherapy and irradiation were applied by Colleoni et al [9].…”

Section: Discussionmentioning

confidence: 99%

“…Until now, only few results have been published using the combination of radio-and chemotherapy [9,24,30,31]. The rationale for this treatment approach is that tumor cells surviving after chemotherapy are sterilized by additional irradiation due to synergistic lethal effects.…”

Section: Introductionmentioning

confidence: 99%

Remission Rates in Breast Cancer Treated with Preoperative Chemotherapy and Radiotherapy

et al. 2003

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“…Based on these results, Skinner et al evaluated preoperative CI 5-FU with concurrent radiation therapy in patients with unresectable locally advanced breast cancer. These investigators found that the combination of CI 5-FU and radiation therapy was effective in converting inoperable breast cancer to resectable disease, with an objective clinical response obtained in a high percentage of patients [62].…”

Section: Other Cancersmentioning

confidence: 99%

UFT� plus oral leucovorin calcium (Orzel?) and radiation in combined modality therapy: A comprehensive review

Minsky

2001

Int. J. Cancer

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Preoperative 5-fluorouracil and radiation therapy for locally advanced breast cancer

Cited by 29 publications

References 17 publications

Thermochemoradiotherapy Improves Oxygenation in Locally Advanced Breast Cancer

Thermochemoradiotherapy Improves Oxygenation in Locally Advanced Breast Cancer

Remission Rates in Breast Cancer Treated with Preoperative Chemotherapy and Radiotherapy

UFT� plus oral leucovorin calcium (Orzel?) and radiation in combined modality therapy: A comprehensive review

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