2010
DOI: 10.1007/s00213-010-2035-0
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Prenatal stress: Role in psychotic and depressive diseases

Abstract: Rationale-The birth of neurons, their migration to appropriate positions in the brain, and their establishment of the proper synaptic contacts happen predominately during the prenatal period. Environmental stressors during gestation can exert a major impact on brain development and thereby contribute to the pathogenesis of neuropsychiatric illnesses, such as depression and psychotic disorders including schizophrenia.Objective-The objectives here are to present recent preclinical studies of the impact of prenat… Show more

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Cited by 227 publications
(168 citation statements)
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“…Finally, although genetic effects are crucial to elucidating the cause of SCZ, non-genetic factors (such as prenatal stress, exposure to viruses during pregnancy, and social disorganization of neighborhoods) should not be ignored. [25][26][27] In conclusion, this study validated the association of the rs11191580 polymorphism within NT5C2 with SCZ susceptibility in a South Chinese Han population. Furthermore, this work is the first to report that GWAS-supported variant rs11191580 conferred negative and lack of response symptoms in SCZ.…”
Section: Tablesupporting
confidence: 68%
“…Finally, although genetic effects are crucial to elucidating the cause of SCZ, non-genetic factors (such as prenatal stress, exposure to viruses during pregnancy, and social disorganization of neighborhoods) should not be ignored. [25][26][27] In conclusion, this study validated the association of the rs11191580 polymorphism within NT5C2 with SCZ susceptibility in a South Chinese Han population. Furthermore, this work is the first to report that GWAS-supported variant rs11191580 conferred negative and lack of response symptoms in SCZ.…”
Section: Tablesupporting
confidence: 68%
“…Neurodevelopmental animal models include maternal immune activation, prenatal malnutrition, the interruption of neurogenesis by methylazoxymethanol (MAM) and the neonatal ibotenic acid lesion of the ventral hippocampus 113,114 . Additional models are represented by the exposure of pregnant mice to unpredictable stress, maternal separation or birth complications [115][116][117] . All of these models have revealed behavioural deficits associated either with positive, cognitive or negative symptoms of schizophrenia, and alterations in the dopaminergic, glutamatergic, GABAergic and serotonergic systems [118][119][120][121][122][123][124] .…”
Section: Vulnerability Of Our Youth: Neurodevelopmentmentioning
confidence: 99%
“…Various programming stimuli, such as periods of foetal malnutrition, which result in intrauterine growth restriction (IUGR), are associated with heightened risk for metabolic and cardiovascular disease [3][4][5] . The long-term consequences of compromised gestation, as indexed by IUGR, also give rise to a range of psychiatric effects [6][7][8] , including increased risk for emotional disorders [9][10][11] . The biological mechanisms whereby events occurring before birth can influence emotionality later in life remain unknown.…”
mentioning
confidence: 99%