Prenatal stress changes courtship vocalizations and bone mineral density in mice

Schmidt, Michaela; Lapert, Florian; Brandwein, Christiane; Deuschle, Michael; Kasperk, Christian; Grimsley, Jasmine M. S.; Gass, Peter

doi:10.1016/j.psyneuen.2016.11.003

Cited by 6 publications

(11 citation statements)

References 78 publications

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“… Starting from GD 5–9 or 8–12 and continuing through the lactation, dams were exposed to soiled bedding from unfamiliar males ( Heiming et al, 2009 , 2011 ). From GD 13–17, dams were restrained in beakers with water for 45 min, three times daily ( Van den Hove et al, 2011 ; Schmidt et al, 2017 , 2022 ). From GD 7–19, dams were given 30 min of restraint twice daily ( Heslin and Coutellier, 2018 ).…”

Section: Prenatal Stressmentioning

confidence: 99%

“…From GD 13–17, dams were restrained in beakers with water for 45 min, three times daily ( Van den Hove et al, 2011 ; Schmidt et al, 2017 , 2022 ).…”

Section: Prenatal Stressmentioning

confidence: 99%

“…An additional concern is that individual variation in a dam’s response to stress can lead to litter effects, in which measures taken from pups within a specific litter correlate. One way to control for litter effects is by using only one to three offspring per litter for a particular study ( Schmidt et al, 2017 , 2022 ; Heslin and Coutellier, 2018 ; Papale et al, 2022 ). Alternatively, statistical methods are available that control for litter in the analyses ( Jiménez and Zylka, 2021 ).…”

Section: Considerations For Preclinical Study Designmentioning

confidence: 99%

“…The generation of a mouse knockout line is often the first step in developing a genetic mouse model. In cases where the full deletion is lethal, as with some high-confidence NDD genes ( Oliver and Davies, 2009 ; Schmidt et al, 2017 , 2022 ; Clarke et al, 2019 ; Jimenez et al, 2020 ), the heterozygous mutant can serve as a potential model. Notably, the HET genotype can be more reflective of mutant alleles in human disorders than null deletions ( Toma et al, 2014 ; Michetti et al, 2022 ), with the drawback that partial loss of a gene does not have the same impact as total knockout.…”

Section: Use Of Pns In Mouse Models Of Ndd Genetic Susceptibilitymentioning

confidence: 99%

“… Gpr88 (G-protein coupled receptor 88), encodes an orphan G protein coupled receptor, associated with schizophrenia and ADHD ( Ben Hamida et al, 2022 ). Nr3c1 (nuclear receptor subfamily 3, group C, member 1), a gene for the receptor that binds glucocorticoids, leading to regulation of gene transcription and associated with ADHD ( Schmidt et al, 2017 ). Npas4 (Neuronal PAS domain protein 4), a gene for a transcription factor with a role in excitatory/inhibitory balance, associated with ASD, schizophrenia, and other NDDs ( Heslin and Coutellier, 2018 ).…”

Section: Overview Of Published Studies: Pns Effects In Genetic Mouse ...mentioning

confidence: 99%

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Prenatal stress unmasks behavioral phenotypes in genetic mouse models of neurodevelopmental disorders

Harper,

Harp,

Moy

2023

Front. Behav. Neurosci.

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Neurodevelopmental disorders (NDDs) are complex conditions characterized by heterogeneous clinical profiles and symptoms that arise in infancy and childhood. NDDs are often attributed to a complicated interaction between genetic risk and environmental factors, suggesting a need for preclinical models reflecting the combined impact of heritable susceptibility and environmental effects. A notable advantage of “two-hit” models is the power to reveal underlying vulnerability that may not be detected in studies employing only genetic or environmental alterations. In this review, we summarize existing literature that investigates detrimental interactions between prenatal stress (PNS) and genes associated with NDDs, with a focus on behavioral phenotyping approaches in mouse models. A challenge in determining the overall role of PNS exposure in genetic models is the diversity of approaches for inducing stress, variability in developmental timepoints for exposure, and differences in phenotyping regimens across laboratories. Identification of optimal stress protocols and critical windows for developmental effects would greatly improve the use of PNS in gene × environment mouse models of NDDs.

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Section: Prenatal Stressmentioning

confidence: 99%

“…From GD 13–17, dams were restrained in beakers with water for 45 min, three times daily ( Van den Hove et al, 2011 ; Schmidt et al, 2017 , 2022 ).…”

Section: Prenatal Stressmentioning

confidence: 99%