Prenatal stress unmasks behavioral phenotypes in genetic mouse models of neurodevelopmental disorders
Kathryn M. Harper,
Samuel J. Harp,
Sheryl S. Moy
Abstract:Neurodevelopmental disorders (NDDs) are complex conditions characterized by heterogeneous clinical profiles and symptoms that arise in infancy and childhood. NDDs are often attributed to a complicated interaction between genetic risk and environmental factors, suggesting a need for preclinical models reflecting the combined impact of heritable susceptibility and environmental effects. A notable advantage of “two-hit” models is the power to reveal underlying vulnerability that may not be detected in studies emp… Show more
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