Prenatal sonographic markers of the outcome in fetuses with bronchopulmonary sequestration

Cho, Min Kyong; Lee, Mi‐Young; Kang, Jieun; Kim, Juhee; Won, Hye‐Sung; Lee, Pil-Ryang; Jeong, Euiseok; Lee, Byong Sop; Kim, Ellen Ai‐Rhan; Yoon, Heemang; Lee, Jin Seoung; Han, Minkyu

doi:10.1002/jcu.22780

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…Along with improvements in prenatal ultrasonography technology, many fetal structure malformations with typical sonographic features like PS can be detected antenatally. The mean gestational age at diagnosis of prenatally diagnosed cases in the present study (26.51 ± 5.25 weeks) is significantly higher than those reported in Switzerland (22.2 ± 3.1 weeks) [ 35 ]and Korea (23.5 ± 2.2 weeks) [ 38 ]. The percentage of stillbirths in the study was as high as 50.42%, which can be ascribed to the high percentage of antenatally diagnosed cases and subsequent TOPs.…”

Section: Discussioncontrasting

confidence: 82%

“…More than 90% of concomitant circulatory system malformations of PS were congenital heart defects. One possible explanation is that an intrathoracic mass may compress the fetal heart and cause structural changes [ 38 ]. Consistent with previous reports [ 2 , 6 , 8 , 14 , 43 ], CDH was another frequently co-occurring malformation of PS.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiology and prevalence of pulmonary sequestration in Chinese population, 2010–2019

Gao

et al. 2023

BMC Pulm Med

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Background Pulmonary sequestration (PS) is the second common congenital lung malformation and has been known for over 150 years. However, there is a scarcity of epidemiological studies on it. This study aimed to characterize the epidemiology of pulmonary sequestration in Chinese population in the recent decade by using a nationwide database. Methods Using data from the Chinese Birth Defects Monitoring Network during 2010–2019, the prevalence rates for PS were calculated by birth year, maternal age, residence area, geographical region, and infant sex. Variations in prevalence and changes over time were further examined. Other variables of interest for analysis included the pregnancy outcomes of affected infants, the prenatal diagnosis, and the co-occurring anomalies of PS cases. Results During the study period, we identified an average prevalence rate of 0.31, 0.11, and 0.42 per 10,000 live and still births for the isolated, non-isolated, and overall PS, respectively. An upward trend was observed for each category of PS. The prevalence rates varied significantly by maternal age (< 20 years, 0.34/10,000; 20–24 years, 0.33/10,000; 25–29 years, 0.45/10,000; 30–34 years, 0.46/10,000; ≥ 35 years, 0.36/10,000), residence area (urban vs. rural, 0.51/10,000 vs. 0.30/10,000), geographical region (western, 0.33/10,000; eastern, 0.49/10,000; central, 0.43/10,000), and by infant sex (male vs. female, 0.45/10,000 vs. 0.38/10,000). Non-isolated PS cases were more likely born prematurely than isolated cases (15.29% vs. 7.83%). 40.28% and 33.80% of non-isolated cases were accompanied by additional respiratory, and circulatory system malformations, respectively. Conclusions The study presents for the first time the prevalence of pulmonary sequestration in Chinese population. The rising prevalence and relatively poor perinatal outcome of affected fetuses or newborns indicate the necessity to improve perinatal management of PS.

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Section: Discussioncontrasting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Epidemiology and prevalence of pulmonary sequestration in Chinese population, 2010–2019

Gao

et al. 2023

BMC Pulm Med

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“…6,10,11 BPS can be diagnosed prenatally by routine ultrasonography, when it resembles a hyper echogenic solid mass, commonly appearing like a wedge. 12,13 Doppler ultrasound is frequently used to identify the systemic feeding artery, which is pathognomonic for a BPS. 14,15 In two-thirds of cases, the lesion regresses during gestation, in some cases even becoming undetectable on consecutive ultrasonography or postnatal chest X-ray.…”

Section: Introductionmentioning

confidence: 99%

The Diagnostics and Management of Bronchopulmonary Sequestration: An International Survey among Specialized Caregivers

Kersten,

Jansen,

Zuidweg

et al. 2024

Eur J Pediatr Surg

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Background Our objective was to explore the treatment preferences for bronchopulmonary sequestration (BPS) among an international group of specialized caregivers. Methods Sixty-three participants from 17 countries completed an online survey concerning the diagnostics, treatment, and follow-up. Recruitment took place among members of the Collaborative Neonatal Network for the first European Congenital Pulmonary Airway Malformation Trial Consortium and through the Association for European Pediatric and Congenital Cardiology working group database. Results Most of the 63 participants were pediatric surgeons (52%), followed by pediatric pulmonologists (22%), and pediatric cardiologists (19%). The majority (65%) treated more than five cases per year and 52% standardly discussed treatment in a multidisciplinary team. Half of the participants (52%) based the management on the presence of symptoms, versus 32% on the intralobar or extralobar lesion localization. Centers with both surgical and interventional cardiac/radiological facilities (85%) preferred resection to embolization in symptomatic cases (62 vs. 15%). In asymptomatic cases too, resection was preferred over embolization (38 vs. 9%); 32% preferred noninterventional treatment, while 11% varied in preference. These treatment preferences were significantly different between surgeons and nonsurgeons (p < 0.05). Little agreement was observed in the preferred timing of intervention as also for the duration of follow-up. Conclusions This survey demonstrates a variation in management strategies of BPS, reflecting different specialist expertise. Most centers treat only a handful of cases per year and follow-up is not standardized. Therefore, management discussion within a multidisciplinary team is recommended. Recording patient data in an international registry for the comparison of management strategies and outcomes could support the development of future guidelines. Level of Evidence: Level IV.

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Outcome of fetal congenital pulmonary malformations: a systematic review and meta-analysis

Sileo,

Alameddine,

Iaccarino

et al. 2024

Journal of Perinatal Medicine

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Objectives To report the outcome of fetuses with a prenatal diagnosis of congenital lung malformation (CLM) diagnosed on ultrasound by performing a comprehensive assessment of these outcomes through a systematic review and meta-analysis. Content CLMs are a heterogeneous group of anomalies that involve the lung parenchyma and its bronchovascular structures. Their presentation and evolution are variable, from entirely asymptomatic lesions with sonographic regression in utero to hydropic fetuses requiring fetal therapy, intrauterine death or neonatal morbidity. A systematic review was conducted in Medline, Embase and Cochrane databases including studies on fetuses with CLM diagnosed prenatally in order to report the in-utero natural history of these lesions. Thirty-nine studies (2,638 fetuses) were included in the final review. Summary Regression/reduction in size of the lung lesion during pregnancy was reported in 31 % of cases, while its increase in 8.5 % of cases. Intra-uterine death complicated 1.5 % of pregnancies with fetal CLM, while neonatal and perinatal death were 2.2 and 3 %, respectively. Neonatal morbidity occurred in 20.6 % of newborns with CLM; 46 % had surgery, mainly elective. In fetuses with CLM and hydrops, fetal/perinatal loss occurred in 42 %. Assessment of the role of fetal therapy in improving the outcomes of pregnancies complicated by CLM was hampered by the small number of included cases and heterogeneity of type of interventions. Outlook Fetuses with CLM prenatally diagnosed have a generally favorable outcome. Conversely, there is a low quality of evidence on the actual role of fetal therapy in improving the outcome of fetuses presenting with these anomalies.

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Prenatal sonographic markers of the outcome in fetuses with bronchopulmonary sequestration

Cited by 3 publications

References 30 publications

Epidemiology and prevalence of pulmonary sequestration in Chinese population, 2010–2019

Epidemiology and prevalence of pulmonary sequestration in Chinese population, 2010–2019

The Diagnostics and Management of Bronchopulmonary Sequestration: An International Survey among Specialized Caregivers

Outcome of fetal congenital pulmonary malformations: a systematic review and meta-analysis

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