Thermosetting terpolymer composed of benzoxazine (BA-a), cyanate ester (BADCy) and epoxy resin (E 44 ) was prepared via co-curing reactions. The curing procedure for the ternary blend was studied by differential scanning calorimetry (DSC) and Fourier transform-infrared spectroscopy (FT-IR), and the thermal, mechanical and dielectric properties of the terpolymer were also characterized. The DSC results manifested a multiple curing pattern, suggesting the complexity of the reactions in the system. The FT-IR analysis further showed that the curing procedure involves several steps, firstly the cyclotrimerisation of cyanate ester after oxazine ring opening, followed by the isomerization of cyanurate and the reaction of isocyanurate with epoxy to form oxazolidinone, and finally the copolymerization of the remaining epoxy with benzoxazine and the self-polymerization of benzoxazine. Compared to the polybenzoxazine, the higher crosslinking density of the terpolymer led to the higher glass transition temperature (T g ), as well as the 5% and 10% weight loss temperatures (T d5 and T d10 ), indicating the better thermal stability of the terpolymer at service temperature. And the data for the mechanical and dielectric properties also showed that the terpolymer performs better than polybenzoxazine and the copolymer.
Alzheimer's disease (AD) is a devastating neurodegenerative disease that causes progressive damage to neurons. Emerging evidence has demonstrated that long non-coding RNAs (lncRNAs) serve an important role in many neurological diseases, such as AD. β-secretase 1 (BACE1)-antisense transcript (BACE1-AS) was identified as a conserved non-coding antisense BACE1. Previous reports stated that BACE1-AS positively regulated BACE1 mRNA and subsequently BACE1 protein expression and. However, whether BACE1-AS is able to regulate memory and learning behaviors remains to be elucidated. In the present study, the role of lncRNA BACE1-AS on memory and learning was investigated. It was demonstrated that lncRNA BACE1-AS expression was highly expressed in blood samples from AD patients, and also upregulated in peripheral blood samples and hippocampi from an AD animal model. Knockdown of BACE1-AS by short interfering RNA increased the primary hippocampal neurons proliferation . Knockdown of BACE1-AS mediated by lentivirus improved the memory and learning behaviors of SAMP8 mice, inhibited BACE1 and amyloid precursor protein production, and phosphorylation of tau protein in hippocampi. Therefore, the present findings suggested that BACE1-AS may be a potential target for management of memory loss related diseases, such as AD.
The CXCR4 antagonist AMD3100 exerts therapeutic effects on experimental colitis by inhibiting colonic inflammation and enhancing epithelial barrier integrity.
Emodin attenuates pulmonary edema and inflammation, enhances alveolar epithelial barrier function, and promotes expression of claudin-4, claudin-5 and occludin in lung tissue samples from rats with acute pancreatitis.
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