Prenatal phthalate exposure and infant size at birth and gestational duration

Shoaff, Jessica R.; Romano, Megan E.; Yolton, Kimberly; Lanphear, Bruce P.; Calafat, Antònia M.; Braun, Joseph M.

doi:10.1016/j.envres.2016.05.033

Cited by 56 publications

(49 citation statements)

References 43 publications

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“…The results are indeed very heterogeneous as previously pointed out by Zee et al in his review [40]. More recently, some studies suggested a positive association between in utero phthalate exposure and low birth weight [46,47], while others did not [43,48,49].…”

Section: From Placenta To Newbornmentioning

confidence: 75%

Endocrine-Disrupting Chemicals in Human Fetal Growth

Street

Bernasconi

2020

IJMS

100

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Fetal growth is regulated by a complex interaction of maternal, placental, and fetal factors. The effects and outcomes that chemicals, widely distributed in the environment, may have on the health status of both the mother and the fetus are not yet well defined. Mainly mixtures of chemical substances are found in the mothers and placenta. Exposure to endocrine-disrupting chemicals (EDCs) can be associated with fetal growth retardation, thyroid dysfunction, and neurological disorders. EDCs mostly interfere with insulin, glucocorticoid, estrogenic, and thyroid pathways, with subsequent effects on normal endocrine and metabolic functions, which cause changes in the epigenome and state of inflammation with life-long effects and consequences. International scientific societies recommend the implementation of research and of all possible preventive measures. This review briefly summarizes all these aspects.

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Section: From Placenta To Newbornmentioning

confidence: 75%

Endocrine-Disrupting Chemicals in Human Fetal Growth

Street

Bernasconi

2020

IJMS

100

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“…Others have found that DEHP and DBP exposure resulted in fewer litters, fewer live pups, and a decrease in the proportion of pups born alive, in a dose-dependent manner (Lamb et al 1987; Gray et al 2006). Over a dozen studies have examined the association between prenatal phthalate exposure and fetal weight or birth weight in humans, however results and conclusions varied by study design, frequency of exposure assessment (most relied on a single measurement in pregnancy), and biological matrix (not all measured phthalate metabolites in urine) (Marie et al 2015; Casas et al 2016; Lenters et al 2016; Shoaff et al 2016; de Cock et al 2016; Huang et al 2014). A well-designed study by Ferguson et al (2016) assessing prenatal urinary phthalates reported robust inverse associations of ΣDEHP metabolites and ultrasound based fetal weight (Ferguson et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Paternal and maternal urinary phthalate metabolite concentrations and birth weight of singletons conceived by subfertile couples

Messerlian

Braun

Mínguez-Alarcón

et al. 2017

Environment International

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Background Ortho-phthalates are known endocrine disruptors. Prenatal phthalate exposure has been inconsistently associated with fetal growth and infant birth weight; however, the effect of paternal and maternal preconception exposure remains understudied. Objectives To investigate associations of paternal and maternal preconception and maternal prenatal urinary phthalate metabolite concentrations with birth weight. Methods The study comprised 364 singletons born to 364 mothers and 195 fathers (195 couples) from the EARTH Study, a prospective cohort of couples from Boston, MA. Births were categorized by mode of conception: in-vitro fertilization based (IVF) (n=208) or non-IVF based (n=156, intrauterine insemination or non-medically assisted/natural conception). We measured urinary concentrations of eleven phthalate metabolites in maternal (n=1,425) and paternal (n=489) preconception and maternal prenatal (n=781) samples. Birth weight was abstracted from delivery records. Covariate-adjusted associations between loge-phthalate metabolite concentrations and birth weight were evaluated separately by mode of conception using multivariable linear regression. Results Each loge-unit increase in paternal urinary concentration of the sum of di(2-ethylhexyl) phthalate (ΣDEHP) metabolites was associated with a 90 gram (95% CI: −165, −15) decrease in birth weight among IVF singletons, but not among non-IVF singletons (18 grams; 95% CI: −76, 113). Additional adjustment for maternal prenatal ΣDEHP concentrations modestly strengthened findings among IVF singletons. While few associations were found with maternal preconception phthalate metabolites, we observed an inverse relationship between several maternal prenatal urinary phthalate metabolite concentrations and birth weight among IVF singletons in covariate-adjusted models. However, with further adjustment for specific paternal phthalate metabolite concentrations, these associations were attenuated and no longer significant. Conclusions Paternal preconception urinary concentration of ΣDEHP metabolites was associated with a decrease in birth weight among IVF-conceived singletons. These results, if replicated, highlight the importance of preconception health, especially among subfertile couples.

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“…Somewhat surprisingly, we found that phthalate polymers from drugs appear to have similar effects. Some studies have addressed the potential association between environmental phthalate exposure (assessed by biomarkers) and PTB or differences in gestational age 3,[25][26][27][28][29][30][31][32] . Studies that focus on gestational age are less conclusive, whereas studies that address the risk of PTB, support an association.…”

Section: Commentmentioning

confidence: 99%