Prenatal phthalate causes cryptorchidism postnatally by inducing transabdominal ascent of the testis in fetal rats

Imajima, Tatsuro; Shono, Toshiyuki; Zakaria, Ossama M; Suita, Sachiyo

doi:10.1016/s0022-3468(97)90083-x

Cited by 63 publications

(38 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, histological damage in testis, kidney and liver during pregnancy and suckling [63], cryptorchidism after prenatal exposition [64] and persistent thyroid hyperactivity [65] were observed. Then, polycystic kidney disease and a decrease in kidney function [66,67] as well as a dose-dependent decrease of cell viability in kidney epithelial cells [68], hypotension and cardiac arrest [69], decrease in the concentration of vitamin E in liver and testis [70] and finally peroxisome proliferation in liver, kidney and brain [71][72][73][74] were also reported.…”

Section: Evidence Of Toxicity In Experimental Animalsmentioning

confidence: 98%

Potential Hazards of Exposure to Di-(2-Ethylhexyl)-Phthalate in Babies

Latini

2000

Neonatology

View full text Add to dashboard Cite

Many plastic items are made of polyvinylchloride (PVC) blended with plasticizers. The most frequently used plasticizer is di-(2-ethylhexyl)-phthalate (DEHP). DEHP migrates at a constant rate from plastics to the environment: it has been detected in water, soil and food and is therefore considered as a widespread environmental contaminant. Over the past several years, a number of publications concerning toxic effects of DEHP on animals and humans have been reported. Although DEHP is suggested to be of low acute toxicity, long-term exposure, especially in human beings at risk such as pregnant women and children, requires more in-depth studies. If DEHP toxicity in humans were to be confirmed, it would be advisable in the future to replace current PVC plasticizers, especially if they come into contact with babies, with better-quality materials.

show abstract

Section: Evidence Of Toxicity In Experimental Animalsmentioning

confidence: 98%

Potential Hazards of Exposure to Di-(2-Ethylhexyl)-Phthalate in Babies

Latini

2000

Neonatology

View full text Add to dashboard Cite

show abstract

“…A reproductive trial showed a decrease of the pregnancy rate of the female rats coupled with MBP-treated adult male rats associated with declining sperm counts in the epididymis (Wine et al, 1997). Previous studies have demonstrated that MBP exposure has an adverse effect on testicular descent and germ cell development in both prenatal and postnatal rats (Imajima et al, 1997;Shono et al, 2005). A prenatal short-time exposure to MBP induces a long-term effect on postnatal rats and impairs reproductive function in male offspring (Kai et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Mono-butyl phthalate-induced mouse testis injury is associated with oxidative stress and down-regulated expression of <i>Sox9</i> and <i>Dazl </i>

Xiong

Zhang

et al. 2017

J. Toxicol. Sci.

View full text Add to dashboard Cite

-Mono-butyl phthalate (MBP) has reproductive toxicity but the related mechanisms have not been fully elucidated in vivo. We exposed male Balb/c mice to MBP by gavage at doses of 0, 25, 50, 100, 200 mg/kg for 14 days, and then evaluated the testicular alterations at the histological and molecular levels. MBP reduced mouse sperm count along with sperm malformation and seminiferous tubule degeneration in a dose-dependent manner. MBP dosed at 200 mg/kg significantly increased reactive oxygen species and malondialdehyde content in mouse testes. High doses of MBP (200 mg/kg) also significantly reduced mRNA expressions of testis growth and function related genes (Sox9 and Dazl). Our findings suggest that oxidative stress and down-regulated expression of Sox9 and Dazl may play important roles in MBP-induced testis injury.

show abstract

“…Testicular toxicity of phthalates has been documented. Studies have indicated that these chemicals may affect sperm cells, sperm mobility, chryptorchidism and hypospadias, in laboratory animals (Imajima et al, 1993;Poon et al, 1997;Arcadi et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Phthalate ester plasticizers in freshwater systems of Venda, South Africa and potential health effects

Fatoki¹,

Bornman²,

Ravandhalala³

et al. 2010

WSA

View full text Add to dashboard Cite

Phthalate ester plasticizers were determined in rivers and dams of the Venda region, South Africa. Liquid-liquid extraction, column chromatographic clean-up and capillary gas chromatography were the methods used for the quantitative analyses. Levels of phthalates in water samples from the rivers and dams ranged from 0.16 mg/ℓ to 10.17 mg/ℓ and varied between 0.02 mg/kg and 0.89 mg/kg in sediments. Generally, the highest concentrations of phthalates were found as DBP and DEHP, which is consistent with their common use in plastic materials and other industrial chemicals. The phthalate levels found in the water samples were much higher than the criterion of 3 µg/ℓ phthalates recommended by the United States Environmental Protection Agency (USEPA) for the protection of fish and other aquatic life, and higher than the Suggested No-Adverse Effect Levels (SNAEL) of 7.5 to 38.5 µg/ℓ for drinking water. The health risk-assessment studies on the phthalates found in the water systems suggested potential carcinogenic and other toxic effects they may pose to communities downstream which might be exposed either through drinking untreated water from the rivers, through dermal absorption or by using the freshwater sources to water their vegetable gardens. DEHP posed the highest risk potential of all the phthalates and the water use or exposure pathway that appeared to pose the highest potential health risk for carcinogenic as well as toxic effects was vegetable watering. The results for phthalates in the water samples give cause for environmental concern as people's health downstream is at stake if rural populations use this water.

show abstract

Prenatal phthalate causes cryptorchidism postnatally by inducing transabdominal ascent of the testis in fetal rats

Cited by 63 publications

References 15 publications

Potential Hazards of Exposure to Di-(2-Ethylhexyl)-Phthalate in Babies

Potential Hazards of Exposure to Di-(2-Ethylhexyl)-Phthalate in Babies

Mono-butyl phthalate-induced mouse testis injury is associated with oxidative stress and down-regulated expression of <i>Sox9</i> and <i>Dazl </i>

Phthalate ester plasticizers in freshwater systems of Venda, South Africa and potential health effects

Contact Info

Product

Resources

About