Prenatal PFOS exposure induces oxidative stress and apoptosis in the lung of rat off-spring

Chen, Tian; Zhang, Ling; Yue, Junqiu; Lv, Ziquan; Xia, Wei; Wan, Yanjian; Li, Yuanyuan; Xu, Shunqing

doi:10.1016/j.reprotox.2011.03.003

Cited by 68 publications

(55 citation statements)

References 36 publications

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“…Zinc oxide nanoparticles exposure induced oxidative stress in the gills, live and gut of zebrafish [43]. The perfluorooctane sulfonate exposure induced oxidative stress in the lung of rat off-spring [22]. The results showed the similar trend as the description of Kim and they found that the ZnO-NPs joint and 1.6 mg/l of the PFOS joint exposure groups as compared with that in the control, respectively (Figure 5e).…”

Section: Effects Of Pfos and Zno-nps On Caspase-3 And Caspase-9 Activsupporting

confidence: 69%

“…also reported that the ZnO-NPs induced the caspase-3 activity in cultured primary astrocytes [28]. Chen et al (2012) proved that the PFOS induced activity of the caspase-3 and caspase-9 upregulation in the lung of rat [22]. The Figure 5 showed that the PFOS and ZnO-NPs induced apoptosis by up-regulation of p53 and Bax gene expression in a dose-dependent manner.…”

Section: Discussionmentioning

confidence: 93%

“…Zinc oxide nanoparticles exposure to zebrafish embryo induced the cellular oxidative stress response and the ROS generation [21]. The perfluorooctane sulfonate could induce oxidative stress and apoptosis in the lung of rat offspring [22]. Apoptosis is the process of programmed cell death (PCD) that occurs in multicellular organisms.…”

Section: Oxidative Stress and Apotosis To Zebrafish (Danio Rerio) Embmentioning

confidence: 99%

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Oxidative stress and apotosis to Zebrafish (Danio rerio) embryos exposed to perfluorooctane sulfonate (PFOS) and ZnO nanoparticles

Cai

Wang

et al. 2017

Int J Occup Med Environ Health

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Objectives: Perfluorooctane sulfonate (PFOS) and zinc oxide nanoparticles (ZnO-NPs) are frequently detected in the environment but few studies have assessed the joint toxicity of them. Oxidative stress and apoptosis to zebrafish (Danio rerio) embryos induced by the PFOS and ZnO-NPs were investigated in this study. Material and Methods: The embryos were exposed to the PFOS (0, 0.4, 0.8 and 1.6 mg/l), 25, 50 mg/l) and PFOS plus ZnO-NPs (0.4+12.5, 0.8+25 and 1.6+50 mg/l) mixture solutions until 96 h post-fertilization. Activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (Gpx) and malondialdehyde (MDA) content were measured in zebrafish embryos after exposure lasting for 96 h. At the same time, the genes expression related to reactive oxygen species (ROS) generation, oxidative damage and apoptosis were also measured. Results: A significant induction of the ROS accompanied by the increase in the activity of the Gpx and MDA contents were found in co-treatment groups. Furthermore, several apoptosis pathway related genes such as Bax, p53, caspase-3 and caspase-9 were significantly up-regulated in the PFOS plus ZnO-NPs exposure groups, while anti-apoptotic gene Bcl-2 was significantly down-regulated in the PFOS plus ZnO-NPs exposure groups. In addition, some oxidative stress-related genes such as Cat, GSH peroxidase 1 (Gpx1a) and superoxide dismutase 1 (Sod1) were also significantly down-regulated after the PFOS plus ZnO-NPs co-treatments. Conclusions: The results demonstrated that the PFOS plus ZnO-NPs co-exposure could cause more serious oxidative stress and apoptosis than the PFOS and ZnO-NPs exposure alone at the exposure concentrations above. The synergistic effects of the PFOS and ZnO-NPs may be the important mechanisms of their toxicity to zebrafish embryos. Int J Occup Med Environ Health 2017;30(2):213-229

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Section: Effects Of Pfos and Zno-nps On Caspase-3 And Caspase-9 Activsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 93%

Section: Oxidative Stress and Apotosis To Zebrafish (Danio Rerio) Embmentioning

confidence: 99%

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Oxidative stress and apotosis to Zebrafish (Danio rerio) embryos exposed to perfluorooctane sulfonate (PFOS) and ZnO nanoparticles

Cai

Wang

et al. 2017

Int J Occup Med Environ Health

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“…In utero or early life exposure of rodents to PFOS, PFHxS or PFOA also caused developmental toxicities in adults, including pulmonary injuries [237], uterine and mammary gland development delays (or stimulation, depending on gender, strain and dose), sometimes at very low doses [26, 91,229,238,239]; glucose and lipid metabolic disorders [240];…”

Section: Animals Experience a Range Of Adverse Effects Usually At Himentioning

confidence: 99%

Per- and polyfluorinated substances (PFASs): Environmental challenges

Krafft

Riess²

2015

Current Opinion in Colloid & Interface Science

214

120

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“…However, there is still a lack of understanding of the toxicokinetics and mode(s)/mechanism(s) of immunotoxic action of PFOS. During the last decade, at the cellular level, PFOS has been shown to induce different biochemical changes, several of which are typically associated with apoptosis (Liu et al, 2007;Chen et al, 2011;Kim et al, 2011). Therefore, PFOS toxicity is thought to be caused, in part, by the induction of apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of perfluorooctanesulfonate (PFOS)-induced apoptosis in the immunocyte

Zhang

Wang

Dong

et al. 2012

Journal of Immunotoxicology

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Prenatal PFOS exposure induces oxidative stress and apoptosis in the lung of rat off-spring

Cited by 68 publications

References 36 publications

Oxidative stress and apotosis to Zebrafish (Danio rerio) embryos exposed to perfluorooctane sulfonate (PFOS) and ZnO nanoparticles

Oxidative stress and apotosis to Zebrafish (Danio rerio) embryos exposed to perfluorooctane sulfonate (PFOS) and ZnO nanoparticles

Per- and polyfluorinated substances (PFASs): Environmental challenges

Mechanism of perfluorooctanesulfonate (PFOS)-induced apoptosis in the immunocyte

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