Mechanism of perfluorooctanesulfonate (PFOS)-induced apoptosis in the immunocyte

Zhang, Yinghua; Wang, Jing; Dong, Guang‐Hui; Liu, Miaomiao; Da, Wang; Zheng, Li; Jin, Yinlong

doi:10.3109/1547691x.2012.691123

Cited by 45 publications

(22 citation statements)

References 53 publications

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“…The decrease of GST activity was consistent with similar observations in previous findings. For example, a recent research reported that the GST activity of mice exposed to PFOS decreased significantly and agreed well with our result (Zhang et al, 2013). A reduction in GST may indicate Daphnia magna failed to detoxicate and resist oxidative stress in the cell (Santos et al, 2004).…”

supporting

confidence: 93%

Effects of Perfluorooctane sulfonate on immobilization, heartbeat, reproductive and biochemical performance of Daphnia magna

Liang

Shi

et al. 2017

Chemosphere

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supporting

confidence: 93%

Effects of Perfluorooctane sulfonate on immobilization, heartbeat, reproductive and biochemical performance of Daphnia magna

Liang

Shi

et al. 2017

Chemosphere

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“…However, in line with direct effects of PFOS on components of the immune system, PFOS was reported to induce apoptosis in splenocytes and thymocytes isolated from mice exposed to PFOS (potassium salt, purity 98%), at 1, 5 or 10 mg/kg bw per day for 7 days (Zhang et al., ). A significant increase in the number of G1 cell populations was seen after treatment with 5 mg/kg bw per day in splenocytes and in thymocytes treated with 10 mg/kg bw per day.…”

Section: Assessmentmentioning

confidence: 95%

Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food

Knutsen¹,

Alexander²,

Barregård³

et al. 2018

EFS2

180

199

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The European Commission asked EFSA for a scientific evaluation on the risks to human health related to the presence of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in food. Regarding PFOS and PFOA occurrence, the final data set available for dietary exposure assessment contained a total of 20,019 analytical results (PFOS n = 10,191 and PFOA n = 9,828). There were large differences between upper and lower bound exposure due to analytical methods with insufficient sensitivity. The CONTAM Panel considered the lower bound estimates to be closer to true exposure levels. Important contributors to the lower bound mean chronic exposure were 'Fish and other seafood', 'Meat and meat products' and 'Eggs and egg products', for PFOS, and 'Milk and dairy products', 'Drinking water' and 'Fish and other seafood' for PFOA. PFOS and PFOA are readily absorbed in the gastrointestinal tract, excreted in urine and faeces, and do not undergo metabolism. Estimated human half-lives for PFOS and PFOA are about 5 years and 2-4 years, respectively. The derivation of a health-based guidance value was based on human epidemiological studies. For PFOS, the increase in serum total cholesterol in adults, and the decrease in antibody response at vaccination in children were identified as the critical effects. For PFOA, the increase in serum total cholesterol was the critical effect. Also reduced birth weight (for both compounds) and increased prevalence of high serum levels of the liver enzyme alanine aminotransferase (ALT) (for PFOA) were considered. After benchmark modelling of serum levels of PFOS and PFOA, and estimating the corresponding daily intakes, the CONTAM Panel established a tolerable weekly intake (TWI) of 13 ng/kg body weight (bw) per week for PFOS and 6 ng/kg bw per week for PFOA. For both compounds, exposure of a considerable proportion of the population exceeds the proposed TWIs.

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“…It has been well documented that transcriptional activation of the tumor suppressor gene p53 and the proto‐oncogene c‐myc are associated with apoptotic processes (Achanzar et al ., ; McCarthy et al ., ). Recent findings showed that PFOS induced apoptosis of hepatoma cells and immunocytes with increased expression of p53 (Dong et al ., ; Hu and Hu, ; Zhang et al ., ). Microarray analysis of PFOS‐exposed chicken embryonic hepatocytes revealed that the differentially expressed genes were involved in both p53 and c‐myc signaling (O'Brien et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Proteomic analysis of perfluorooctane sulfonate‐induced apoptosis in human hepatic cells using the iTRAQ technique

Huang

Zhang

Peng

et al. 2013

J of Applied Toxicology

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Perfluorooctane sulfonate (PFOS) is one of the most commonly used perfluorinated compounds, whose environmental exposure has been associated with a number of adverse health outcomes. However, the molecular mechanisms involved in PFOS toxicity are still not well elucidated. In the present study, we applied iTRAQ labeling quantitative proteomic technology to investigate the differential protein expression profiles of non-tumor human hepatic cells (L-02) exposed to PFOS. A total of 18 proteins were differentially expressed in a dose-dependent manner in PFOS-treated cells versus the control. Among these, 11 proteins were up-regulated and 7 were down-regulated. Gene ontology analysis indicated that PFOS would exert toxic effects on L-02 cells by affecting multiple biological processes, including protein biosynthesis and degradation, mRNA processing and splicing, transcription, signal transduction and transport. Furthermore, the proteomic results especially proposed that the inhibition of HNRNPC, HUWE1 and UBQLN1, as well as the induction of PAF1 is involved in the activation of the p53 and c-myc signaling pathways, which then trigger the apoptotic process in L-02 cells exposed to PFOS. Overall, these data will aid our understanding of the mechanisms responsible for PFOS-mediated hepatotoxicity, and develop useful biomarkers for monitoring and evaluating PFOS contamination in the environment.

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Mechanism of perfluorooctanesulfonate (PFOS)-induced apoptosis in the immunocyte

Cited by 45 publications

References 53 publications

Effects of Perfluorooctane sulfonate on immobilization, heartbeat, reproductive and biochemical performance of Daphnia magna

Effects of Perfluorooctane sulfonate on immobilization, heartbeat, reproductive and biochemical performance of Daphnia magna

Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food

Proteomic analysis of perfluorooctane sulfonate‐induced apoptosis in human hepatic cells using the iTRAQ technique

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