Prenatal maternal stress is associated with behavioural and epigenetic changes in Japanese quail

Charrier, Marion; Lumineau, Sophie; Georgelin, Marion; Meurisse, Maryse; Palme, Rüpert; Angelier, Frédéric; Cornilleau, Fabien; Constantin, P.; Coustham, Vincent; Nicolle, Céline; Bertin, Aline; Darmaillacq, Anne-Sophie; Dickel, Ludovic; Guemene, Daniel D.; Calandreau, Ludovic; Houdelier, Cécilia

doi:10.1016/j.psyneuen.2022.105661

Cited by 5 publications

(2 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The development process is characterized by multiple time windows in which organisms have strong plasticity and are very sensitive to environmental stimuli ( Musillo, Berry & Cirulli, 2022 ). Embryonic stage is the key period of brain development, studies have found that prenatal maternal stress have an adverse effect on the emotional and cognitive development of their offspring ( Chagas et al, 2021 ; Charrier et al, 2022 ; Glynn & Baram, 2019 ; Marchisella et al, 2021 ; Sandman et al, 2018 ). The hypothalamic pituitary adrenal (HPA) axis is a physiological system and play a key role in regulating the relationship between prenatal maternal stress and offspring development outcomes ( Constantinof, Moisiadis & Matthews, 2016 ; Nakamura, Osonoi & Terauchi, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Contribution of hippocampal BDNF/CREB signaling pathway and gut microbiota to emotional behavior impairment induced by chronic unpredictable mild stress during pregnancy in rats offspring

Zhao

Wang

Wen

et al. 2022

PeerJ

View full text Add to dashboard Cite

Background Numerous studies have shown that exposure to prenatal maternal stress (PMS) is associated with various psychopathological outcomes of offspring. The accumulating evidence linking bacteria in the gut and neurons in the brain (the microbiota-gut-brain axis) has been aconsensus; however, there is a lack of research on the involvement mechanism of gut microbiota in the regulation of the BDNF/CREB signaling pathway in the hippocampus of prenatally stressed offspring. Methods Pregnant rats were subjected to chronic unpredictable mild stress (CUMS) to establish the prenatal maternal stress model. The body weight was measured and the behavioral changes were recorded. Offspring were tested to determine emotional state using sucrose preference test (SPT), open-field test (OFT) and suspended tail test (STT). Gut microbiota was evaluated by sequencing the microbial 16S rRNA V3–V4 region, and the interactive analysis of bacterial community structure and diversity was carried out. The expression of hippocampal BDNF, TrkB and CREB mRNA and proteins were respectively measured using RT-PCR and Western blotting. Results Prenatal maternal stress increased maternal plasma corticosterone levels, slowed maternal weight gain and caused depression-like behaviors (all P < 0.05). In offspring, prenatal maternal stress increased plasma corticosterone levels (P < 0.05) and emotional behavior changes (depression-like state) were observed (P < 0.05). The species abundance, diversity and composition of the offspring’s gut microbiota changed after the maternal stress during pregnancy (P < 0.05). Compared with the control group’s offspring, the species abundance of Lactobacillaceae was dropped, while the abundance of the Muribaculaceae species abundance was risen. Concurrent, changes in the hippocampal structure of the offspring and decreases in expression of BDNF/CREB signaling were noted (P < 0.05). Conclusions Prenatal maternal stress leads to high corticosterone status and abnormal emotion behavior of offspring, which may be associated with the abnormal BDNF/CREB signaling in hippocampus of offspring caused by the change of gut microbiota composition.

show abstract

Section: Introductionmentioning

confidence: 99%

Contribution of hippocampal BDNF/CREB signaling pathway and gut microbiota to emotional behavior impairment induced by chronic unpredictable mild stress during pregnancy in rats offspring

Zhao

Wang

Wen

et al. 2022

PeerJ

View full text Add to dashboard Cite

show abstract

“…The development process is characterized by multiple time windows in which organisms have strong plasticity and are very sensitive to environmental stimuli (Musillo, et al 2022). Embryonic stage is the key period of brain development, studies have found that prenatal maternal stress have an adverse effect on the emotional and cognitive development of their offspring (Chagas, et al 2021;Charrier, et al 2022;Glynn and Baram 2019;Marchisella, et al 2021;Sandman, et al 2018). The hypothalamic pituitary adrenal (HPA) axis is a physiological system and play a key role in regulating the relationship between prenatal maternal stress and offspring development outcomes (Constantinof, et al 2016;Nakamura, et al 2010).…”

mentioning

confidence: 99%

Peer Review #2 of "Contribution of hippocampal BDNF/CREB signaling pathway and gut microbiota to emotional behavior impairment induced by chronic unpredictable mild stress during pregnancy in rats offspring (v0.2)"

2022

View full text Add to dashboard Cite

The presence of a mother counteracts prenatal stress in a precocial bird

et al. 2022

View full text Add to dashboard Cite

Prenatal maternal stress is associated with behavioural and epigenetic changes in Japanese quail

Cited by 5 publications

References 49 publications

Contribution of hippocampal BDNF/CREB signaling pathway and gut microbiota to emotional behavior impairment induced by chronic unpredictable mild stress during pregnancy in rats offspring

Contribution of hippocampal BDNF/CREB signaling pathway and gut microbiota to emotional behavior impairment induced by chronic unpredictable mild stress during pregnancy in rats offspring

Peer Review #2 of "Contribution of hippocampal BDNF/CREB signaling pathway and gut microbiota to emotional behavior impairment induced by chronic unpredictable mild stress during pregnancy in rats offspring (v0.2)"

The presence of a mother counteracts prenatal stress in a precocial bird

Contact Info

Product

Resources

About